Epidemiology of Pancreatic Cancer in Saudi Arabia: A Retrospective Analysis of Pancreatic Cancer Diagnosed in Saudi Arabia Between 2004 and 2015

Alghamdi, Ibrahim G; Almadi, Majid A.; Alsohaibani, Fahad; Mosli, Mahmoud; DeVol, Edward; Abaalkhail, Faisal; Alsaif, Faisal; Al–Hamoudi, Waleed; Al‐Sanea, Nasser; Hassanain, Mazen; Alqahtani, Saleh

doi:10.2147/ceg.s289269

Cited by 15 publications

(17 citation statements)

References 22 publications

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“…This is mainly because in countries with a high HDI, life longevity increases one’s risk of developing pancreatic cancer. Also, the availability and ease of access to medical care with an advanced and systematic cancer registration may explain the increased reported incidence in such countries [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Pancreatic cancer in the MENA region, a bibliometric review

Nassereldine¹,

Awada²,

Ali³

et al. 2022

ecancer

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Background Most Middle East and North Africa (MENA) countries record pancreatic cancer incidence rates that are above the world’s average. Reducing this burden requires evidence-based policies. This bibliometric review aims to examine the status of pancreatic cancer research in the MENA world, while systematically categorising publications across cancer care pathways. Methods We searched Scopus, Medline and PubMed for peer-reviewed publications related to both pancreatic cancer and MENA countries by using controlled vocabulary and keywords. The results were screened for duplicates and later included in the analysis based on preset eligibility criteria. A structured data extraction form was used to collect data related to each article, its methodology, its cancer care pathway, funding status and authorship. Results A total of 5,848 publications resulted from our search, from which 1,098 articles remained after applying the eligibility criteria. Trends show a steady increase in pancreatic cancer research by MENA. Case reports are the most common, whereas a lack in high-evidence clinical studies as well as public health and epidemiological research was evident. Most studies were not funded and had no female contributions. Funding, if present, came mostly from foreign states. There exists a much greater focus in research on diagnosis and treatment among other cancer care pathways. Most MENA-based studies did not involve collaborations with other countries. Country gross domestic product and population are both correlated to the research output. Conclusion This bibliometric analysis identified significant gaps and limitations in pancreatic cancer research in MENA countries. Vital domains requiring research investment have also been highlighted as a first step towards evidence-based health policies.

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Section: Introductionmentioning

confidence: 99%

Pancreatic cancer in the MENA region, a bibliometric review

Nassereldine¹,

Awada²,

Ali³

et al. 2022

ecancer

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“…This finding could be attributed to the poor prognosis that is usually associated with this type of cancer at the time of diagnosis. 18 Nevertheless, this study has reported pancreatic cancer in one patient only, thus further evaluation of such finding is needed.…”

Section: Discussionmentioning

confidence: 80%

Breaking Bad News of a Cancer Diagnosis: A Mixed-Methods Study of Patients’ Perspectives

Al-Johani¹,

AlShamlan²,

AlGhamdi³

et al. 2022

PPA

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A cancer diagnosis is an overwhelming process for both patients and doctors. Many studies have addressed doctors' opinions and knowledge regarding breaking bad news (BBN). However, scarce knowledge exists regarding patients' perspectives for communicating bad news. Therefore, the current study aims to assess cancer patient preferences and satisfaction about BBN. Patients and Methods: This is a mixed methods study consisting of two phases; an in-depth interview and cross-sectional quantitative analysis. Thematic analysis was used for the qualitative data to explore patients' satisfaction and preferences about BBN. For quantitative analyses, the overall satisfaction was calculated as satisfaction percent. Bivariate analyses were performed, and statistical significance was set as p < 0.05. Quality function deployment was used to effectively define patient requirements of highest priority.Results: Thematic analysis revealed two main themes. Theme 1; patients' requirements for BBN and theme 2; patients' reaction at the time of diagnosis with their categories. For the quantitative part, a total of 222 patients responded to the survey, females made up 70% of the sample. Satisfaction score percent ranged from 25.5 to 100%, with a mean of 82.7±11.9%. The most preferred items were mainly concerned with the doctor being honest and encouraging, good listener and interacting giving simple smooth explanations without using medical terms, and empathetic (average score 4.8/5). Also, providing the diagnosis in a calm and private environment (4.7/5). Analysis also found that the requirements for improvement included providing a written summary after receiving the diagnosis and patient perception assessed by the doctor before telling the diagnosis. Conclusion:Communicating bad news effectively is crucial in the management of cancer patients. The process of BBN should be patient-centered, focusing on patients' needs. Thus, the current study has demonstrated the patients' preferences and the requirements, which should be incorporated into BBN protocols.

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“…Pancreatic cancer is the seventh leading cause of death worldwide, and in 2018, the International Agency for Research on Cancer estimated that the age-standardized incidence rate for pancreatic cancer in Saudi Arabia among both sexes across age groups was 2.2 per 100 000 individuals 8 . There are multiple risk factors for pancreatic cancer, one of which is obesity, as observed in our patient 9 .…”

Section: Discussionmentioning

confidence: 99%

Pancreatic cancer presenting with acute pancreatitis complicated by Wernicke’s encephalopathy and a colonic fistula: a case report

Ibnawadh¹,

Alashgar

Peedikayil

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and Importance: This account details the case of a 39-year-old male patient who presented with acute necrotizing hemorrhagic pancreatitis. The comorbid conditions of Wernicke’s encephalopathy, and a pancreatic–colonic fistula developed during his care. This case is unique in that it illustrates the effects of these complications individually and through their interaction. Given that there are no firm guidelines regarding the nature and timing of interventions for a pancreatic–colonic fistula diagnosis, this case may provide helpful information. Case Presentation: As previously noted, this is the case of a 39-year-old male patient with a BMI of 46 kg/m2 who presented with acute necrotizing hemorrhagic pancreatitis. Complications developed as noted above. Multiple diagnostic imaging methods were utilized but failed to detect the presence of metastatic pancreatic adenocarcinoma. After a course of antimicrobial and nutritional therapy, we attempted surgical intervention for the pancreatic–colonic fistula and pancreatic abscess debridement. Unfortunately, during that procedure, we observed extensive carcinomatosis, at which point we did a gastrojejunostomy. Subsequently, the patient’s condition did not permit chemoradiotherapy. After completion, we transferred the patient to palliative care, where he died. Clinical Discussion: This case was complex due to the previously recounted results of the underlying condition, pancreatic adenocarcinoma, and the complications of Wernicke’s encephalopathy and pancreatic–colonic fistula. The presence of risk factors in patients increases the need to perform appropriate diagnostic tests. Even with tests and multiple imaging modalities, these particular events remain challenging to diagnose, given the nature of the development and presentation of the disease condition. It was only after the surgical intervention that the carcinoma became evident. Early screening and imaging could improve detection rates and prevent disease progression. Conclusion: In this case report of acute hemorrhagic necrotizing pancreatitis and its complications, we discuss the factors making this disease process particularly difficult to diagnose, detect, and manage. Even though the complications detailed herein are rare, in this case, the significance is the need to evaluate all patients with acute pancreatitis and acute confusion for Wernicke’s encephalopathy, which is preventable. In addition, suggestive findings on computed tomography signal the need for further investigation of the colonic fistula. Finally, at this time, there are no clear guidelines for the surgical management of these complications. We hope that this case report will contribute to their development.

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Epidemiology of Pancreatic Cancer in Saudi Arabia: A Retrospective Analysis of Pancreatic Cancer Diagnosed in Saudi Arabia Between 2004 and 2015

Cited by 15 publications

References 22 publications

Pancreatic cancer in the MENA region, a bibliometric review

Pancreatic cancer in the MENA region, a bibliometric review

Breaking Bad News of a Cancer Diagnosis: A Mixed-Methods Study of Patients’ Perspectives

Pancreatic cancer presenting with acute pancreatitis complicated by Wernicke’s encephalopathy and a colonic fistula: a case report

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