Parkinson’s disease has exhibited the most rapid increase in prevalence among neurodegenerative disorders over the past 25 years. With the expanding availability of its surgical interventions and the controversial side effects identified in the literature, it is urgent to develop instruments for discerning subtle changes in patients’ biopsychosocial functioning. Therefore, the primary objective of this study was to culturally adapt the Deep Brain Stimulation Impairment Scale (DBS-IS) into Brazilian Portuguese and evaluate its content validity. The final version of the DBS-IS in Brazilian Portuguese comprises 19 Likert items and yielded an S-CVI of 0.97, indicating robust content validity. Given the escalating number of Parkinson’s disease diagnoses annually in Brazil, this tool may prove beneficial for practitioners and could also contribute to clarifying some of the apparent disparities among users of brain stimulation therapies worldwide and in Brazil.