Epidemiology of patients with lymphangioleiomyomatosis: A descriptive study using the national database of health insurance claims and specific health checkups of Japan

Kimura, Yuya; Jo, Taisuke; Hashimoto, Yohei; Kumazawa, Ryosuke; Ishimaru, Miho; Matsui, Hiroki; Yokoyama, Akira; Tanaka, Goh; Yasunaga, Hideo

doi:10.1016/j.resinv.2024.03.010

Respiratory Investigation

2024

DOI: 10.1016/j.resinv.2024.03.010

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Epidemiology of patients with lymphangioleiomyomatosis: A descriptive study using the national database of health insurance claims and specific health checkups of Japan

Yuya Kimura,

Taisuke Jo,

Yohei Hashimoto

et al.

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2024

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Cited by 2 publications

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Clinical research using real-world data: A narrative review

Kimura,

Jo,

Matsui

et al. 2024

Respiratory Investigation

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Clinical research using real-world data: A narrative review

Kimura,

Jo,

Matsui

et al. 2024

Respiratory Investigation

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Diagnostic value of serum vascular endothelial growth factor-D in Korean patients with lymphangioleiomyomatosis

Yoon,

Moon,

Kim

et al. 2024

Ther Adv Respir Dis

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Background: Lymphangioleiomyomatosis (LAM) is a rare multisystemic disorder characterized by the proliferation of abnormal smooth muscle-like cells. Although serum vascular endothelial growth factor-D (VEGF-D) is currently used as a diagnostic biomarker for LAM, its diagnostic value in Korean patients is unclear. Objectives: To evaluate the diagnostic value of serum VEGF-D for LAM in Korean patients. Design: A multicenter prospective cohort study Methods: Serum samples were prospectively collected from five medical institutions, from patients with LAM ( n = 40) and controls ( n = 24; healthy participants = 3, other cystic lung diseases = 13, idiopathic pulmonary fibrosis = 4, idiopathic nonspecific interstitial pneumonia = 4). Serum VEGF-D levels were measured using the enzyme-linked immunosorbent assay, and the diagnostic value was evaluated using receiver operating characteristic (ROC) curve analysis. Results: The mean age of patients with LAM was 44.5 years, and all were female (controls: 47.8 years; female: 70.8%, p < 0.001). The serum VEGF-D levels were significantly higher in patients with LAM than those in the control group (median: 708.9 pg/mL vs 325.3 pg/mL, p < 0.001). In the ROC curve analysis, serum VEGF-D levels showed good predicting performance for LAM diagnosis (area under the curve = 0.918) with an optimal cut-off value of 432.7 pg/mL (sensitivity = 85.0%, specificity = 87.5%). When 800 pg/mL was used as the cut-off value, the specificity of serum VEGF-D for LAM diagnosis increased to 100.0%. Conclusion: Our results suggest that serum VEGF-D may be a useful biomarker for diagnosing LAM in Korean patients, similar to previous reports.

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Epidemiology of patients with lymphangioleiomyomatosis: A descriptive study using the national database of health insurance claims and specific health checkups of Japan

Cited by 2 publications

References 21 publications

Clinical research using real-world data: A narrative review

Clinical research using real-world data: A narrative review

Diagnostic value of serum vascular endothelial growth factor-D in Korean patients with lymphangioleiomyomatosis

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