Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies

Harada, Ryuichi; Hamasaki, Yuko; Okuda, Yusuke; Hamada, Riku; Ishikura, Kenji

doi:10.1007/s00467-021-05145-1

Cited by 73 publications

(39 citation statements)

References 117 publications

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“…There is no comprehensive epidemiological data regarding the prevalence of CKD in children due to the different classification and diagnostic definitions for CKD in children. [ 1 2 ] It is estimated that it ranges between 15 and 74.7 per one million of the age-related population (pmarp). [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Nonalcoholic Fatty Liver Disease in Children with Renal Failure Underwent Treatment with Dialysis

Madihi

Tavakoli

Riahinezhad

et al. 2022

International Journal of Preventive Medicine

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Background: In this study, we aimed to investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) in children with renal failure under treatment with dialysis and its association with biochemical measurements. Methods: In this cross-sectional study, children aged less than 18 years with chronic kidney disease (CKD) who were under treatment with dialysis at least 3 months ago were enrolled. To evaluate fatty liver in those patients who had no recent liver ultrasonography (last 6 months), liver ultrasonography was performed. The characteristics of patients with renal failure with and without NAFLD based on the ultrasonographic evaluation were compared. The association between NAFLD and the studied variables was evaluated. Results: In this study, 39 children (31 males and 8 females) with renal failure who underwent treatment with dialysis were included. From the studied population, six (19.4%) had NAFLD based on ultrasonographic evaluation. There were no differences between renal failure patients with and without NAFLD regarding the biochemical and anthropometric characteristics (P > 0.0). Conclusions: The prevalence of NAFLD in our studied children with renal failure who underwent treatment with dialysis was like the general population and it was not associated with the biochemical and anthropometric characteristics of the patients. Given the importance of NAFLD in renal failure patients as well as its subtle nature, it is recommended to screen patients with CKD for NAFLD.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Nonalcoholic Fatty Liver Disease in Children with Renal Failure Underwent Treatment with Dialysis

Madihi

Tavakoli

Riahinezhad

et al. 2022

International Journal of Preventive Medicine

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“…Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of kidney failure in children and one of the most common indications for kidney transplantation. 1 Morphologic phenotypes vary, ranging from severe malformations such as bilateral kidney agenesis to milder conditions such as urinary tract dilation. 2 The overall prevalence of CAKUT is estimated at 4 to 60 events per 10 000 births.…”

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confidence: 99%

“…Etiologies are multifactorial and include familial, genetic, epigenetic, and environmental factors. 1 As survival of extremely preterm infants born prior to 28 weeks' gestation continues to improve, the ability to diagnose and manage associated comorbidities becomes increasingly essential to improving patient outcomes. Over the last decade, efforts to prevent and recognize acute kidney injury (AKI; a common comorbidity in infants with CAKUT) in extremely preterm infants have quickly transformed research and bedside care as pharmacists, clinicians, and nurses have begun to scrutinize nephrotoxic medication use while seeking to identify the earliest warning signs of kidney disease.…”

mentioning

confidence: 99%

Congenital Anomalies of the Kidney and Urinary Tract in Preterm Infants—Active Drivers of Increased Disease or Associated Bystanders?

Mohamed

Slaughter

2022

JAMA Netw Open

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Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of kidney failure in children and one of the most common indications for kidney transplantation. 1 Morphologic phenotypes vary, ranging from severe malformations such as bilateral kidney agenesis to milder conditions such as urinary tract dilation. 2 The overall prevalence of CAKUT is estimated at 4 to 60 events per 10 000 births. 2 CAKUT are often diagnosed during routine prenatal ultrasonography or postnatally in infants with associated clinical signs and symptoms. Incidental diagnoses may also occur. Etiologies are multifactorial and include familial, genetic, epigenetic, and environmental factors. 1As survival of extremely preterm infants born prior to 28 weeks' gestation continues to

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“…Среди хромосомных аномалий и пороков, по данным различных авторов, от 20 до 50% приходится на врожденные аномалии развития органов мочевой системы (ВАРМС) [2][3][4]. Большинство вовремя не диагностированных ВПР органов мочевой системы (ОМС) долгое время не имеют клинической симптоматики, при этом у части пациентов (от 30 до 60%) они приводят к развитию хронической болезни почек (ХБП) и хронической почечной недостаточности (ХПН) [2][3][4][5].…”

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Assessment of antenatal risk factors for the formation of congenital defects of the development of the urinary system in children

Сергеева

Шуматова

et al. 2022

Medicinskij sovet

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Introduction. In the Russian Federation, the number of new cases of congenital malformations and chromosomal abnormalities reported among children from birth to 14 years of age each year is over 1,000 per 100,000 population. Therefore, the urgency of the problem of diagnosis and prevention of congenital malformations does not admit of doubt.Purpose of the study. To study the influence of antenatal risk factors on the formation of the urinary system’s congenital malformations in children.Materials and methods. The study carried out by the “case – control” method. The main group included 126 mothers who gave birth to children with kidney and urinary tract defects, and the control group included 40 women with healthy children. The assessment of the results reliability the obtained carried out by calculating the odds ratio with a 95% confidence interval.Results. The most significant factors in the formation of malformations of the urinary system were: the age of mothers over 35 years old (OR 3.264, 95% CI: 1.079–9.875), a burdened obstetric history (OR 2.380, 95% CI: 1.012–5.594), a burdened gynecological anamnesis (OR 2.825, 95% CI: 1.319–6.051), preeclampsia (OR 2.910, 95% CI: 1.057–8.010), exacerbation of opportunistic infections during pregnancy (OR 2.833, 95% CI: 1.103–7.280), the presence of chronic placental insufficiency (OR 3.413, 95% CI: 1.405–8.290), passive smoking during pregnancy (OR 2.711, 95% CI: 1.110–6.618), a burdened nephrological history in the mother (OR 3.462, 95% CI: 1.148–10.442), the presence of neurocirculatory dystonia (OR 4.703, 95% CI: 1.062–20.822). The work revealed the role of folate metabolism genes polymorphisms in the formation of kidney defects. In addition, a reliable relationship between the development of kidney and urinary tract defects with the absence of pregravid preparation was found, as well as untimely intake of folic acid preparations.Conclusions. The study made it possible to identify the most significant factors of the antenatal period, influencing the development of congenital malformations of the urinary system. The results obtained must be taken into account at the stages of planning pregnancy in an outpatient setting.

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Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies

Cited by 73 publications

References 117 publications

Prevalence of Nonalcoholic Fatty Liver Disease in Children with Renal Failure Underwent Treatment with Dialysis

Prevalence of Nonalcoholic Fatty Liver Disease in Children with Renal Failure Underwent Treatment with Dialysis

Congenital Anomalies of the Kidney and Urinary Tract in Preterm Infants—Active Drivers of Increased Disease or Associated Bystanders?

Assessment of antenatal risk factors for the formation of congenital defects of the development of the urinary system in children

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