Epidemiology of peptic ulcer disease

Sonnenberg, Amnon; Sengupta, Abhishek; Bauerfeind, Peter

doi:10.1007/978-94-009-1245-8_1

Cited by 5 publications

(2 citation statements)

References 93 publications

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“…The incidence of peptic ulcer peaked in the 1950s-1960s and has been in decline for the last few decades. [1][2][3][4] The decline in symptomatic uncomplicated peptic ulcer might be more pronounced than that for serious upper gastrointestinal complications (UGIC, peptic ulcer complicated by haemorrhage or perforation). 5 Despite this decline, peptic ulcer remains a common and important disease.…”

Section: Introductionmentioning

confidence: 99%

Uncomplicated peptic ulcer in the UK: trends from 1997 to 2005

Cai

Rodrı́guez

Massó-González

et al. 2009

Aliment Pharmacol Ther

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Section: Introductionmentioning

confidence: 99%

Uncomplicated peptic ulcer in the UK: trends from 1997 to 2005

Cai

Rodrı́guez

Massó-González

et al. 2009

Aliment Pharmacol Ther

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“…Peptic ulcer complications present unique challenges for digestive surgeons in the modern era. Although the incidence of surgical emergencies has markedly diminished in recent times, some patients still require elective, urgent, or emergent intervention for complications of ulcers [1,2]. Despite evidence that Helicobacter pylori infections are a critical component in ulcer pathogenesis, and despite the availability of more specific and effective medical treatments, some patients with bleeding, perforation or obstruction of the gastric outlet require surgical treatment [3,4].…”

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confidence: 99%

Parietal Cell Vagotomy versus Vagotomy‐antrectomy: Ulcer Surgery in the Modern Era

Donahue

2000

World j. surg.

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Abstract. Patients with peptic ulcer occasionally develop complications that require surgical intervention, despite the advances in medical treatment and changes in the natural history of disease. The clinical surgeon must make a decision about performing "selective vagotomy antrectomy versus highly selective vagotomy," based on the information discussed herein. The goals for operative treatment remain safe correction of the presenting problem, avoidance of perioperative morbidity and mortality, and freedom from disabling postoperative side effects. This paper addresses broad aspects of the details of surgical interventions; because most operative procedures are performed in urgent circumstances in patients who often have a variety of conditions, it is not surprising that there is no best operation suited to every complication of ulcer.

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Prospective Study of Diet and the Risk of Duodenal Ulcer in Men

Aldoori

Giovannucci

Stampfer

et al. 1997

American Journal of Epidemiology

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The authors examined the associations between dietary factors and the risk of duodenal ulcer in a prospective cohort of 47,806 men, aged 40-75 years, who were free of diagnosed gastric or duodenal ulcer or cancer. During 6 years of follow-up, they documented 138 newly diagnosed cases of duodenal ulcer. They found little evidence for an important effect of fat, type of fat, or protein intake. Higher consumption of fruits and vegetables was associated with lower risk of duodenal ulcer (relative risk (RR) = 0.67, 95% confidence interval (CI) 0.39-1.15 for > or = 7 servings per day vs. < 3 servings per day) after adjustment for age, body mass index, smoking, and use of aspirin or other nonsteroidal anti-inflammatory drugs. Total dietary fiber intake was inversely associated with the risk of duodenal ulcer (RR = 0.55, 95% CI 0.31-0.96 for men in the highest vs. the lowest quintile of dietary fiber). The soluble component of fiber was strongly associated with a decreased risk of duodenal ulcer (RR = 0.40, 95% CI 0.22-0.74 for the highest quintile). Several age- and energy-adjusted nutrients correlated with dietary fiber were also inversely related to the risk of duodenal ulcer, but vitamin A from all sources combined (including supplements and multivitamins) was the only nutrient that was statistically significant after adjustment for other risk factors (RR = 0.46, 95% CI 0.23-0.91 for men in the highest vs. the lowest quintile of vitamin A intake). These findings provide evidence that vitamin A from all sources, as well as diets high in fruits and vegetables, may reduce the development of duodenal ulcer, possibly due to their fiber content. Although the associations appeared stronger for dietary fiber and vitamin A, the authors can not exclude the possibility that other closely correlated dietary factors may be the true protective factors.

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Epidemiology of peptic ulcer disease

Cited by 5 publications

References 93 publications

Uncomplicated peptic ulcer in the UK: trends from 1997 to 2005

Uncomplicated peptic ulcer in the UK: trends from 1997 to 2005

Parietal Cell Vagotomy versus Vagotomy‐antrectomy: Ulcer Surgery in the Modern Era

Prospective Study of Diet and the Risk of Duodenal Ulcer in Men

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