Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data

Baker, Ruth; Orton, Elizabeth; Tata, Laila J.; Kendrick, Denise

doi:10.1093/eurpub/ckw064

Cited by 18 publications

(34 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fractures often follow a bimodal age distribution, with fractures in older individuals being related to osteoporosis and low‐energy trauma (eg fall from standing height), whereas high fracture incidence in young individuals is explained by risk‐increasing activities and high‐energy trauma. In a recent epidemiological study of injury incidence in UK children and young adults (ages 0‐24) by Baker et al, peak fracture incidence was registered among subjects 10‐24 years old . Older participants of the presented study, therefore, are moving away from this high‐risk age.…”

Section: Discussionmentioning

confidence: 66%

Fracture risk of young adults receiving proton‐pump inhibitors and H2‐receptor antagonists

et al. 2019

View full text Add to dashboard Cite

Summary Introduction Proton‐pump inhibitors (PPI) and histamine (type 2) receptor antagonists (H2RA) have the potential to interfere with calcium metabolism. Several authors have evaluated the effect of these medications on fracture incidence in older adults. A recent large epidemiologic study demonstrated a higher risk of fractures in young adults receiving PPI. Aim To evaluate the effect of PPI and H2RA use on fracture incidence in a large retrospective cohort of military recruits representative of general population of young adults. Methods A retrospective cohort of 254 265 male and 234 670 female non‐combat military conscripts ages 18‐25. Subjects were divided into three groups by PPI use (no PPI use, 1‐100 tablets and more than 100 tablets) and two groups by H2RA use (no H2RA use, any H2RA use). Multivariate logistic regression was used to adjust fracture risk for age, BMI, education level, socio‐economic level, ethnic origin, occupation and duration of follow‐up in months. Main outcome measures At least one fracture during the study period. Results Use of PPI and H2RA was not associated with an increased risk of fractures. In men, the predictors of an increased fracture risk were higher BMI (OR = 1.007, P < 0.001), origin from a developing country (OR = 1.15, P < 0.001) and service as a driver (OR = 1.11, P < 0.001). Higher education, higher socioeconomic status and service as an officer or as an administrative worker had a protective effect on fracture incidence. In women, fractures were associated with higher BMI (OR = 1.035, P < 0.001). Origin from a developed country, as well as service as an officer or an administrative worker was associated with lower fracture risk. Conclusions There was no association between the use of PPI or H2‐antagonists and fracture incidence in this retrospective cohort of healthy young military recruits.

show abstract

Section: Discussionmentioning

confidence: 66%

Fracture risk of young adults receiving proton‐pump inhibitors and H2‐receptor antagonists

et al. 2019

View full text Add to dashboard Cite

show abstract

“…9 Toxic effect: Gases, fumes and vapours, unspecified Undifferentiated T60. 9 Toxic effect: Pesticide, unspecified Undifferentiated T62. 9 Toxic effect: Noxious substance eaten as food, unspecified Undifferentiated T65.…”

Section: Discussionmentioning

confidence: 99%

“…8 Toxic effect: Toxic effect of other specified substances Undifferentiated T65. 9 Toxic effect: Toxic effect of unspecified substance Undifferentiated X40…”

Section: Discussionmentioning

confidence: 99%

“…[5] Indeed most adolescent poisoning epidemiology studies to date have examined data from single hospitals or emergency departments [6,7,11,12,[21][22][23][24][25] with few using national hospitalisation, [8,16,17] poison centre, [26] or large primary care datasets including data on primary and secondary care service use. [5,9] What this study adds This is one of the largest population-based studies to date examining adolescent poisoning epidemiology, while CPRD is broadly representative of the demographics of the UK population.…”

Section: What Is Already Known On This Topicmentioning

confidence: 98%

“…However time-trends or social gradients were not explored by poisoning intent. [9] We also reported poisoning incidence in 10-17 year olds between 1992-2012 using primary care data alone. We found intentional poisoning incidence increased with age up to 17 years, increased over time and strong socio-economic gradients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differing patterns in intentional and unintentional poisonings among young people in England, 1998–2014: a population-based cohort study

et al. 2016

Self Cite

View full text Add to dashboard Cite

Background: Accurate and up to date data on changes in poisoning incidence among young people are lacking. Recent linkage of UK primary care, hospital and mortality data allows these to be quantified to inform service delivery.Methods: An open cohort study of 1,736,527 young people aged 10-24 between 1998-2014 was conducted using linked data from the Clinical Practice Research Datalink, Hospital Episode Statistics and Office for National Statistics deaths. Incidence rates by poisoning intent were calculated by age, sex, deprivation and year.Results: Total poisoning incidence rates increased by 25% from 1998/99-2013/14 (adjusted incidence rate ratio (aIRR) 1.25, 95%CI 1.20-1.30). Patterns differed markedly by intent. Intentional poisoning rates increased by 52% while unintentional rates remained unchanged. Intentional rates increased almost exclusively among females, gradually between 1998/99 and 2013/14 among 16-18 (88% increase) and 19-24 (36% increase) year olds but only increased among 10-15 year olds in the last 2 years (79% increase). A two-fold increased risk of poisoning for the most compared to least deprived quintile existed (aIRR 2.21, 95%CI 2.02-2.23) and remained over time. Conclusions:Commissioning of primary and secondary prevention services needs to address the growing problem of intentional poisonings among young people.

show abstract

Risk and prevention of unintentional injuries in children and young people with attention-deficit/hyperactivity disorder

Tyrrell¹,

Prasad²

2021

Paediatrics and Child Health

View full text Add to dashboard Cite

Epidemiology of poisonings, fractures and burns among 0–24 year olds in England using linked health and mortality data

Abstract: Background

Cited by 18 publications

References 27 publications

Fracture risk of young adults receiving proton‐pump inhibitors and H2‐receptor antagonists

Fracture risk of young adults receiving proton‐pump inhibitors and H2‐receptor antagonists

Differing patterns in intentional and unintentional poisonings among young people in England, 1998–2014: a population-based cohort study

Risk and prevention of unintentional injuries in children and young people with attention-deficit/hyperactivity disorder

Contact Info

Product

Resources

About