Epidemiology of polyomavirus BK (BKV) and the emergent African variant in kidney and bone marrow transplant recipients in the Fundacion Valle del Lili in Cali, Colombia

Ocampo, Luz Ángela; Rosso, Fernando; Pacheco, Robinson; Villegas, Adriana

doi:10.1016/j.diagmicrobio.2017.01.025

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…We found that BKV subtype I is the most prevalent subtype among KTx recipients in the United States, followed by BKV subtype IV. These findings are consistent with other countries from different continents . While the data on trend of BK subtypes among other countries were limited, we found a significant positive correlation between year of study and the prevalence of BKV subtype I in the United States, suggesting potential increasing prevalence of BKV subtype I overtime.…”

Section: Discussionsupporting

confidence: 91%

“…After exclusion of 231 articles based on title and abstract for clearly not fulfilling inclusion criteria due to type of article, study design, population or outcome of interest, and 47 articles excluded due to being duplicates, 71 articles were left for full‐length review. Subsequently, 63 articles were additionally excluded (25 articles did not report the outcome of interest; 17 were not observational studies; and 21 articles were excluded because they were from countries outside the United States and/or consisted of a pediatric population). Thus, eight observational studies with a total of 193 samples (urine, blood, and kidney tissues) from 188 BKV‐infected KTX adult recipients in the United States were enrolled.…”

Section: Resultsmentioning

confidence: 99%

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BK polyomavirus genotypes in renal transplant recipients in the United States: A meta‐analysis

Khoury

Aeddula

Boonpheng

et al. 2019

J Evidence Based Medicine

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Background In the United States, increasing ethnic diversity has been apparent. However, the epidemiology and trends of BKV genotypes remain unclear. This meta‐analysis was conducted with the aim to assess the prevalence of BKV genotypes among kidney transplant (KTx) recipients in the United States. Methods A comprehensive literature review was conducted through October 2018 utilizing MEDLINE, Embase, and Cochrane Database to identify studies that reported the prevalence of BKV subtypes and/or subgroups in KTx recipients in the United States. Pooled prevalence rates were combined using random effects, generic inverse variance method. The protocol for this study is registered with PROSPERO (no. CRD42019134582). Results A total of eight observational studies with a total of 193 samples (urine, blood, and kidney tissues) from 188 BKV‐infected KTX recipients were enrolled. Overall, the pooled estimated prevalence rates of BKV subtypes were 72.2% (95% confidence of interval [CI]: 62.7‐80.0%) for subtype I, 6.8% (95% CI: 2.5‐16.9%) for subtype II, 8.3% (95% CI: 4.4‐15.1%) for subtype III, and 16.1% (95% CI: 10.4‐24.2%) for subtype IV, respectively. While metaregression analysis demonstrated a significant positive correlation between year of study and the prevalence of BKV subtype I (slopes = +0.1023, P = .01), there were no significant correlations between year of study and percentages of BKV subtype II‐IV (P > .05). Among KTx recipients with BKV subtype I, the pooled estimated percentages of BKV subgroups were 22.4% (95% CI: 13.7‐34.5%) for subgroup Ia, 30.6% (95% CI: 17.7‐47.5%) for subgroup Ib1, 47.7% (95% CI: 35.8‐59.9%) for subgroup Ib2, and 4.1% (95% CI:1.2‐13.3%) for subgroup Ic, respectively. Conclusion BKV subtype I is the most prevalent subtype among KTx recipients in the United States and its prevalence seems to increasing overtime. Subgroup Ib2 is the most common subgroup among BKV subtype I.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

BK polyomavirus genotypes in renal transplant recipients in the United States: A meta‐analysis

Khoury

Aeddula

Boonpheng

et al. 2019

J Evidence Based Medicine

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“…II и III генотипы обнаруживаются крайне редко (около 5% зарегистрированных случаев): II генотип имеет ограниченные данные о последовательностях, доступных для анализа, III генотип распространен преимущественно в Африке [7,8]. I генотип подразделяется на 4 подгруппы: Ia, Ib1, Ib2 и Ic; IV генотип на 6 -IVa1, IVa2, IVb1, IVb2, IVc1 и IVc2 [9]. Имеются данные, что подгруппы Ib1 и Ib2 были реклассифицированы как VI и V генотипы соответственно [10].…”

Section: геномная организацияunclassified

“…В 49,4% образцов с положительными результатами определения BKPyV выявлен африканский вариант вируса, в 50,6% -дикий штамм. Среди BKPyV-позитивных пациентов 57% были реципиентами почечного трансплантата, 43% -реципиентами гемопоэтических стволовых клеток [9].…”

Section: эпидемиологияunclassified

“…Основной путь передачи BKPyV -воздушнокапельный. Однако на сегодняшний день доказана трансплантационная передача вируса от донора реципиенту [9]. Кроме того, предложен ряд возможных путей передачи после обнаружения вирусных частиц (вирионов) BKPyV в тканях половых органов и сперме, что предполагает передачу половым путем, а также в плаценте и тканях плода, что допускает трансплацентарную передачу [20].…”

Section: патогенезunclassified

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A systematic review. Current understanding of the infection caused by <i>Betapolyomavirus hominis</i>

Prilepskaya

Домонова

2023

jour

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Reactivation of Betapolyomavirus hominis (BKPyV) in kidney and hematopoietic stem cell recipients can lead to serious complications such as BKPyV-associated nephropathy followed by transplant rejection and BKPyV-associated hemorrhagic cystitis. Early diagnosis of the disease is hampering by the possible combination of infection of BKPyV with other post-transplant pathologies and the absence of specific symptoms. Replication of BKPyV is currently the only reliable prognostic sign of the development of long-term consequences, so patient management is basseting on monitoring the concentration of viral DNA. However, consistency between the results of determining the viral load and the development of post-transplant complications associated with BKPyV reactivation cannot be achieving without effective means of standardizing laboratory testing. This review covers the current understanding of the epidemiology; pathogenesis and the clinical features of the disease associated with BKPyV, and also considers in detail the current methods of laboratory diagnosis infection of BKPyV.

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Isolation and Characterization of Antimicrobial Peptides from Bos taurus Bone Marrow

et al. 2018

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Epidemiology of polyomavirus BK (BKV) and the emergent African variant in kidney and bone marrow transplant recipients in the Fundacion Valle del Lili in Cali, Colombia

Cited by 4 publications

References 13 publications

BK polyomavirus genotypes in renal transplant recipients in the United States: A meta‐analysis

BK polyomavirus genotypes in renal transplant recipients in the United States: A meta‐analysis

A systematic review. Current understanding of the infection caused by <i>Betapolyomavirus hominis</i>

Isolation and Characterization of Antimicrobial Peptides from Bos taurus Bone Marrow

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