Epidemiology of Presenile Alzheimer's Disease in Scotland (1974–88)

Whalley, Lawrence J.; Thomas, Brenda; McGonigal, Gerard; McQuade, C; Swingler, Robert; Black, Robert A.

doi:10.1192/bjp.167.6.728

Cited by 33 publications

(16 citation statements)

References 27 publications

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“…Die aus anderen Studien [20,33] Die in der Literatur berichteten Ergebnisse zur Ursachenverteilung der präseni-len Demenzen sind uneinheitlich. Schät-zungen des Anteils der AD reichen von knapp 20 [26] bis mehr als 75 [1], laut Autopsiebefunden findet man FTD bei 8-17 der jüngeren Dementen [3], die Relation von AD zu FTD wird zumeist mit 4:1 angegeben [3].…”

Section: Räumliche Clusterunclassified

Präsenile Demenzen in Gedächtnisambulanzen — Konsultationsinzidenz und Krankheitscharakteristika

et al. 2006

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This study describes the clinical features of presenile dementia diagnosed in memory clinics. It further gives an estimate of the declared incidence for the German city of Munich and surrounding counties. Twelve memory clinics in Switzerland and Germany were considered, among them all of the four in Munich. A total of 267 patients with onset of illness under the age of 65 were included. Only 16 patients (6%) were younger than 50. Men and women were affected about equally often. The most common cause of dementia was Alzheimer's disease (67%), followed by frontotemporal degeneration (13.5%) and vascular (5.6%) dementia. The declared incidence was estimated at 8.3 new cases of dementia per year among 100,000 persons in the 50-64 age range, with an incidence rate of Alzheimer's disease at 6.3/100,000. It can be concluded that memory clinics fulfill an important function in the care of patients with presenile dementia, since they are highly utilized by younger patients in early stages of the illness.

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Section: Räumliche Clusterunclassified

Präsenile Demenzen in Gedächtnisambulanzen — Konsultationsinzidenz und Krankheitscharakteristika

et al. 2006

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“…9 Lower childhood educational attainments 11 and poorer linguistic ability as young adults 12 of patients with dementia and overrepresentation of specific paternal occupations 13 sug-gest that early life environmental factors may contribute to dementia susceptibility. Late-onset diseases like AD are difficult to model satisfactorily when lag periods are uncertain between putative exposure, disease onset, and dementia presentation.…”

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confidence: 99%

Childhood mental ability and dementia

Whalley

Starr²,

Athawes³

et al. 2000

Neurology

237

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“…Variations arise partly because principal urban areas can switch between several alternative supplies as necessary, and partly because of continuous improvements in water quality and analytical techniques during the lifetime of our subjects. Our approach was to examine geographical variation in early-onset AD using small-area geographical analysis (Whalley et al , 1995 a ). This relies on the division of the entire Scottish population into small areas (by postcode), each with about 5000 individuals.…”

Section: Geographical Distribution Of Earlyonset Ad In Scotlandmentioning

confidence: 99%

“…Case kinship analyses of this type were undertaken for one area of high incidence in North Lanarkshire (Whalley et al , 1995 a ). We traced the ancestors of affected persons back to their great-grandparents' generation from records held in Register House, Edinburgh.…”

Section: Genetic and Environmental Risk Factors: Possible Linksmentioning

confidence: 99%

Early-onset Alzheimer's disease in Scotland: environmental and familial factors

Whalley

2001

Br J Psychiatry

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BackgroundAlzheimer's disease (AD) is a common, complex, age-related disorder in which both genetic and environmental factors are important.AimsTo integrate recent studies on genetic and environmental factors in AD into a multi-factorial disease model.MethodDisease models to explain gene-environment interaction in cardiovascular disease are related to observations on AD.ResultsInformative, community-based studies on the genetic epidemiology of AD are rare. Putative risk factors from the Scottish studies include increased paternal age in AD men and coal mining as paternal occupation in both AD and vascular dementia. Migration effects suggest that environmental factors in high-incidence AD areas are important during adult life.ConclusionsThe studies summarised do not provide sufficient data to support a single comprehensive disease model of gene-environment interaction in AD. Future studies will require very large (≥600) sample sizes, molecular genetic analysis, and environmental data that span neurodevelopment and the period between disease onset and appearance of clinical symptoms.

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Epidemiology of Presenile Alzheimer's Disease in Scotland (1974–88)

Abstract: The observed differences in incidence of AD PSD between Scotland's regions are real and some localities have a higher incidence, mostly in central Scotland.

Cited by 33 publications

References 27 publications

Präsenile Demenzen in Gedächtnisambulanzen — Konsultationsinzidenz und Krankheitscharakteristika

Präsenile Demenzen in Gedächtnisambulanzen — Konsultationsinzidenz und Krankheitscharakteristika

Childhood mental ability and dementia

Early-onset Alzheimer's disease in Scotland: environmental and familial factors

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