Epidemiology of primary biliary cirrhosis among women with elevated γ-glutamyl transpeptidase levels in Okinawa, Japan

Sakugawa, Hiroshi; Nakasone, Hiroki; Nakayoshi, Tomofumi; Yamashiro, Tsuyoshi; Maeshiro, Tatsuji; Kobashigawa, Kasen; Kinjo, Fukunori; Saitô, Atsushi; Zukeran, Hiroki; Nakanuma, Yasuni; Ohba, Kazuo

doi:10.1016/s1386-6346(03)00167-0

Cited by 9 publications

(7 citation statements)

References 16 publications

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“…The prevalence of PBC found in our study is similar to that reported in an early evaluation from Italy, in which diagnosis was based on ultrasound scanning, elevated AP and presence of AMA [27], but much lower than the estimated prevalence of PBC for middle-aged women in Japan [28]. However, it is to note that in this latter study the screening comprised only increase in serum γ-GT levels among 4,048 asymptomatic women attending for an annual health check-up.…”

Section: Discussionsupporting

confidence: 87%

Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China

Liu

Wang

et al. 2010

BMC Gastroenterol

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BackgroundPrimary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the presence of anti-mitocondrial autoantibodies (AMA) which has an essential role also for diagnosis. In addition, also some anti-nuclear antibodies (ANA) have been shown to be highly specific PBC. The purpose of this study was to assess the prevalence of PBC among the adults referring hospital for annual health check-up in Southern China by screening sera for PBC-specific autoantibodies.MethodsAMA and ANA were screened in 8,126 adults (mean age 44 ± 15 years, 48% females) by indirect immunofluorenscence (IIF). Positive sera were tested by ELISA/immunoblotting for AMA-M2, anti-sp100 and anti-gp210. A diagnosis of PBC was re-assessed six months after the initial testing.ResultsOut of 8,126 individuals 35 were positive for AMA and 79 positive for ANA. Nineteen, 4, and 3 of the subjects positive for AMA and/or ANA showed reactivity for AMA-M2, anti-sp100 or gp210, respectively, further tested with ELISA/immunoblotting. Fourteen in the 39 individuals positive for AMA at IIF, AMA-M2, anti-gp210, or anti-sp100 had abnormal cholestatic liver functional indices. One definite and 3 probable PBC diagnosis could be made in 4 cases including 3 females and 1 male after half a year.ConclusionsWe found a point prevalence rate of PBC among Southern Chinese adults attending for yearly health check-up of 492 cases per million (95% CI, 128 to 1,093) and 1,558 cases per million (95% CI, 294 to 3,815) for women over 40, a finding similar to prevalence reported in other geographical areas.

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Section: Discussionsupporting

confidence: 87%

Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China

Liu

Wang

et al. 2010

BMC Gastroenterol

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“…The study relying on physician's identification of patients with PBC such as physician surveys or case series reported relatively lower prevalence, whereas the study using population‐based administrative databases and a diagnostic coding algorithm to identify patients showed higher prevalence . Studies using case‐finding methods of AMA screening reported even higher prevalence, shown in a recent study from southern China, the prevalence of PBC was 492 per million population, and in another study from Japan in which AMA was tested for individuals with elevated gamma‐glutamyl transpeptidase, estimated prevalence was 840 per million, much higher than that previously reported in Japan …”

Section: Discussionmentioning

confidence: 89%

Population‐based epidemiology of primary biliary cirrhosis in South Korea

Kim

Choi

et al. 2015

Aliment Pharmacol Ther

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“…The prevalence of SP100 in PBC is about 20%, and it appears highly specific (94%) for a PBC diagnosis [34]. However, of 15 patients with PBC who do not have detectable AMA, seven patients have ANA with a nuclear rim pattern [32]. ANA directs against the nuclear pore membrane GP210 or the nuclear protein SP100 and is highly specific for and correlated with PBC prognosis; it can be used as a useful supplement for diagnosis, especially in AMA-negative PBC patients [59][60][61][62][63][64].…”

Section: Discussionmentioning

confidence: 98%

The accuracy of the anti-mitochondrial antibody and the M2 subtype test for diagnosis of primary biliary cirrhosis: a meta-analysis

Zhao²,

Wang

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The aim of this study was to evaluate the diagnostic value of anti-mitochondrial antibodies (AMAs) and/or the M2 subtype (AMA-M2) in patients with primary biliary cirrhosis (PBC). AMA/AMA-M2 data were obtained by searching electronic databases. Studies showing AMA/ AMA-M2 results in patients with PBC and control groups with other liver diseases or healthy livers were included. The quality of the involved studies was assessed using the QUADAS tool. The pooled sensitivity and specificity were calculated, and stratified analysis was performed according to possible heterogeneity sources. The pooled AMA (all methods) sensitivity and specificity were 84.5% (95% confidence interval (CI) 83.3%-85.6%) and 97.8% (95% CI 97.6%-98.0%), respectively. The positive and negative likelihood ratios were 25.201 (95% CI 17.583-36.118) and 0.162 (95% CI 0.131-0.199), respectively. The current evidence suggests that AMA and AMA-M2 show favorable accuracy for the diagnosis of PBC with high specificity and sensitivity. AMA is a better and more comprehensive marker than AMA-M2. The accuracy established in this meta-analysis is based on clinical studies using patient cohorts from different ethnicities.Keywords: anti-mitochondrial antibody (AMA); anti-mitochondrial antibody/the M2 subtype (AMA-M2); diagnosis; meta-analysis; primary biliary cirrhosis.

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Epidemiology of primary biliary cirrhosis among women with elevated γ-glutamyl transpeptidase levels in Okinawa, Japan

Cited by 9 publications

References 16 publications

Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China

Prevalence of primary biliary cirrhosis in adults referring hospital for annual health check-up in Southern China

Population‐based epidemiology of primary biliary cirrhosis in South Korea

The accuracy of the anti-mitochondrial antibody and the M2 subtype test for diagnosis of primary biliary cirrhosis: a meta-analysis

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