Epidemiology of Primary Central Nervous System Neoplasms

Choi, N. W.; Schuman, Leonard M.; Gullen, Warren H.

doi:10.1093/oxfordjournals.aje.a121158

Cited by 119 publications

(36 citation statements)

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“…Case studies by Parker and Kernohan [51] and by Choi et al [52] showed no differences between patients with brain tumors and control groups. A study at the Mayo Clinic of 3587 residents of Olmstead County revealed individuals who had sustained head trauma with loss of consciousness, posttraumatic amnesia, or skull fracture compared with expected rates for the community showed no significant increased risk of meningioma in a 30,000 person-years of follow-up after injury [53].…”

Section: Head Traumamentioning

confidence: 87%

Epidemiology and etiology of intracranial meningiomas: A review

1996

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The frequency of meningiomas has been the topic of relatively few reports. Hospital-based brain tumor series indicate that the incidence is approximately 20% of all intracranial tumors; population-based studies indicate an overall incidence of 2.3/100,000. Although intracranial tumors as a whole show a higher prevalence in males than in females, meningiomas have a 2:1 female-to-male ratio. Between Caucasians and Africans, African-Americans, and Asians, certain differences also have been noted. Meningiomas in children are rare and differ from those in adults and other childhood tumors; they are even more rare in infants. Several features indicating etiologic factors have been identified, among which are ionizing radiation, head injury, hormones, and other receptor binding sites, genetic factors, and viruses. The most common source of exposure of the head to ionizing radiation is dental radiographic examination. Since 1922, head trauma has been considered a possible risk factor, but recent large studies do not support this link. Several factors have prompted studies of estrogens and progestogens as risk factors for meningiomas. Other studies have sought to determine if certain individuals have an inherited predisposition for developing a meningioma and/or if viruses, which may act alone or with other mutagens, figure into the formation of a meningioma. The most promising studies are those of cytogenetics, and future elucidation of factors associated with the loss of one copy of chromosome 22, another phenomenon that has been identified in meningiomas, may lead to screening tests and gene therapy.

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Section: Head Traumamentioning

confidence: 87%

Epidemiology and etiology of intracranial meningiomas: A review

1996

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“…Trauma as an occasional aetiological factor in the development of brains tumours has been the subject of considerable controversy [1,4,5,8,12,13,19]. The existence of a casual relationship between trauma and tumour has been reported by several authors, usually regarding gliomas and meningiomas.…”

Section: Discussionmentioning

confidence: 99%

“…Many external aetiological factors have been described as cancerogenous in the literature [4,9]; physical-chemical substances, types of radiation, chronic inflammation and viruses. However, trauma as a cause of tumour, particularly meningioma and glioma, remains a controversial subject [1,4,5,8,12,13,19] and the significance of a possible correlation would be considerable, both in pathogenic and legal terms.…”

Section: Introductionmentioning

confidence: 99%

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Development of intracranial meningiomas at the site of cranial fractures remarks on 15 cases

et al. 1995

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“…A few studies have suggested a role of occupational exposures in the petrochemical [1][2][3][4][5] and rubber industries [6][7][8], and among farmers [9]. Several nonoccupational risk indicators, such as familial aggregation [10], ionizing radiation [11][12][13][14], trauma to the head [13][14][15][16], epilepsy [16][17][18], and infections [19] have also been proposed.…”

Section: Introductionmentioning

confidence: 99%

Nonoccupational risk indicators of glioblastoma in adults

et al. 1990

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A case-control study of brain tumor was conducted in collaborating hospitals in Boston, Providence, and Baltimore. Cases were 160 consecutive patients being treated for glioblastoma, grade 3 or 4 astrocytoma, or anaplastic astrocytoma. Controls were 128 healthy persons identified among the case's friends. A complex self-administered questionnaire was used to assess exposure to factors of interest. There was some evidence that glioblastoma is associated with a decreased susceptibility to allergies, a finding that may call attention to the involvement of immunologic disturbances in brain tumors. Our data are not supportive of previous reports of an association between brain tumors and exposure to pets or farm environment, family history of CNS malignancies or other neurologic conditions, or irradiation to the head. We did not find any evidence for an association with life-style characteristics such as cigarette smoking, alcohol consumption, use of drugs of any kind, or dietary intake of cured or smoked meat or fish.

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Epidemiology of Primary Central Nervous System Neoplasms

Cited by 119 publications

References 0 publications

Epidemiology and etiology of intracranial meningiomas: A review

Epidemiology and etiology of intracranial meningiomas: A review

Development of intracranial meningiomas at the site of cranial fractures remarks on 15 cases

Nonoccupational risk indicators of glioblastoma in adults

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