Epidemiology of Primary Central Nervous System Neoplasms

Choi, N. W.; Schuman, Leonard M.; Gullen, Warren H.

doi:10.1093/oxfordjournals.aje.a121134

Cited by 74 publications

(68 citation statements)

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“…As a criterion for accepting a family into the study, at least 2 gliomas per family were required, whereas in most previous studies, families with at least 1 glioma were eligible. [5][6][7][8][9][10][11] In our study, the diluting effect of families with sporadic gliomas is reduced and, therefore, the possibility of detecting cancers associated with hereditary gliomas is increased. The strategy of investigating families with 2 or more gliomas reduces the number of families to be studied but the size of the family is expanded when relatives beyond first-degree are included.…”

Section: Discussionmentioning

confidence: 61%

“…27 The familial occurrence of brain tumors has been confirmed in several epidemiological studies. [5][6][7][8][9] About 4% (11/297) of glioma patients have been shown to have first-degree relatives affected with verified gliomas, which is statistically significantly more than the expected incidence of sporadic gliomas. 8 Our study, investigating pedigrees ranging beyond first-degree relatives, showed that about 9% (30/317) of glioma patients have relatives with gliomas.…”

Section: Discussionmentioning

confidence: 97%

“…[3][4][5][6][7][8][9] In the present study, occurrence of other cancers in families affected with 2 or more gliomas was examined with epidemiological population-based study design. As a criterion for accepting a family into the study, at least 2 gliomas per family were required, whereas in most previous studies, families with at least 1 glioma were eligible.…”

Section: Discussionmentioning

confidence: 99%

“…2 Furthermore, families with multiple gliomas but without obvious connection to known tumour syndromes have been described in several case reports 3,4 and epidemiological studies. [5][6][7][8][9] Our aim was to clarify which other cancers might occur in excess in families affected with 2 or more gliomas. Although a number of epidemiological studies on glioma families have been reported, association with other types of cancer has remained obscure because earlier results have been inconsistent.…”

mentioning

confidence: 99%

“…Although a number of epidemiological studies on glioma families have been reported, association with other types of cancer has remained obscure because earlier results have been inconsistent. [5][6][7][8][9][10][11][12] Therefore, in the present study, the possibility that more than 1 tumour syndrome may involve pedigrees with multiple glioma patients was examined. Unlike most earlier epidemiological studies investigating families with 1 or more gliomas, [5][6][7][8][9][10][11] we focused on families affected with at least 2 verified gliomas.…”

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confidence: 99%

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Cancer incidence in families with multiple glioma patients

Paunu

Pukkala

Laippala

et al. 2001

Intl Journal of Cancer

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Twenty-four Finnish families with 2 or more glioma patients were identified through questionnaires sent to 369 consecutive glioma patients receiving surgery at Tampere University Hospital during 1983-94. To explore whether unusual cancer susceptibility is involved, the cancer risk of 2,664 family members was estimated using population-based data from the Finnish Cancer Registry. Among the total cohort of relatives, 88 cancers were observed during 1953-97. The overall cancer risk among 12 families with juvenile onset gliomas was significantly decreased (standardized incidence ratio [SIR] 0.6, 95% confidence interval [CI]: 0.4 -0.9). Among 12 families with adult onset gliomas, the overall cancer risk was equal to that of the reference population (SIR 1.1, 95% CI: 0.8 -1.4) whereas the risk of skin melanoma (SIR 4.0, 95% CI: 1.5-8.8) and meningioma (SIR 5.5, 95% CI: 1.1-16) were significantly increased. Several other tumors, including those associated with neurofibromatosis 1 and 2, tuberous sclerosis and Li-Fraumeni and Turcot syndromes were surveyed, but no elevated risks were observed. In conclusion, the presence of meningiomas and skin melanomas in glioma families may indicate a novel association as a cancer susceptibility trait.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Cancer incidence in families with multiple glioma patients

Paunu

Pukkala

Laippala

et al. 2001

Intl Journal of Cancer

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Neurocysticercosis Among Patients With Cerebral Gliomas

Brutto

Castillo

Mena

et al. 1997

Archives of Neurology

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Association of adult glioma with medical conditions, family and reproductive history

et al. 1997

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A population-based case-control study of 416 histologically diagnosed, incident gliomas in adults was carried out in Melbourne, Australia, to determine whether past medical, family or reproductive histories are risk factors for developing glioma. A total of 422 controls were selected from the Australian electoral roll and matched to cases for age, sex and post code of residence. An increased risk of developing glioma was observed among first-born individuals OR (95% CI) 2.0 (1.4-2.9). It is possible that this effect is due to residual confounding by socio-economic status or that it is a chance finding. Alternatively, it may be that this is due to some other effect linked to the first pregnancy, such as maternal age, birth weight or circumstances of delivery. There was no apparent association between the development of glioma and other neuropsychiatric or general medical conditions or with family history or reproductive history. Allergies (asthma and eczema) were not associated with a decreased risk of glioma, as has previously been suggested. Glioma is the most common primary brain malignancy in adults, accounting for approximately 75% of all primary adult brain tumours (Green et al., 1976). The prognosis is poor, with a median survival of less than 12 months (Axtell et al., 1983;Whittle et al., 1991) and an increasing incidence over the last 30 years (Davis et al., 1991). The causes of glioma are unknown, and related to this, no preventive strategy is available. Although many possible risk factors for brain tumours have been suggested, there is still no dominant hypothesis. A wide range of genetic and environmental factors have been investigated. While some evidence exists implicating certain work chemicals (Burch et al., 1987;Preston-Martin and Mack, 1991;Morrison et al., 1992), investigations of a wide range of genetic and environmental factors have been inconclusive (Burch et al., 1987;Wrensch and Barger, 1990;Schiffer, 1991;Ryan et al., 1992;Zampieri et al., 1994).A role has been suggested for genetic factors in the aetiology of glioma (Schiffer, 1991;Wrensch and Barger, 1990), but this is not consistent in all studies (Choi et al., 1970). This is based on the following: the difference in distribution of ABO blood groups between brain tumour patients and controls (Selverstone and Cooper, 1961;Zampieri et al., 1994), the association of brain tumours with genetically determined disorders (Schiffer, 1991), some evidence of familial aggregation of brain tumours (Schiffer, 1991) and familial clustering of brain tumours with breast and lung cancers (Wrensch and Barger, 1990;Zampieri et al., 1994).A number of exploratory case-control studies have been reported which examine the association of medical conditions, family and reproductive history in cases with glioma and controls. There are few consistent findings. There is some evidence that allergies may decrease the risk of glioma (Hochberg et al., 1990;Ryan et al., 1992;Schlehofer et al., 1992a). Although in one report the authors suggested that the reproductive a...

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Epidemiology of Primary Central Nervous System Neoplasms

Cited by 74 publications

References 0 publications

Cancer incidence in families with multiple glioma patients

Cancer incidence in families with multiple glioma patients

Neurocysticercosis Among Patients With Cerebral Gliomas

Association of adult glioma with medical conditions, family and reproductive history

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