Epidemiology of Psoriatic Arthritis

Chandran, Vinod

doi:10.3899/jrheum.081242

Cited by 7 publications

(7 citation statements)

References 17 publications

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“…HLA-B*27, present in 7% of North American whites, is also noted in 50% to 70% of patients with axial disease and less than 15% of those with peripheral disease in PsA, and its presence is independent of disease severity. 23 Although also not diagnostic of PsA, HLA-B*27, particularly in the presence of HLA-DR*07, is prognostic for the progression of joint damage in PsA. 37 Table III compares laboratory evaluations in PsA with other types of arthritis that may coexist with psoriasis or that mimic PsA.…”

Section: Physical Examinationmentioning

confidence: 98%

“…[15][16][17][18][19][20][21][22][23] Population heterogeneity and varying methods of disease classification and data acquisition contribute to the difficulty in establishing its true prevalence. Although the incidence of PsA among patients with psoriasis varies among epidemiologic studies, it is apparent that it is a common disorder.…”

Section: Psoriatic Arthritis Key Pointsmentioning

confidence: 99%

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Recognizing psoriatic arthritis in the dermatology clinic

Garg

Gladman

2010

Journal of the American Academy of Dermatology

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Section: Physical Examinationmentioning

confidence: 98%

Section: Psoriatic Arthritis Key Pointsmentioning

confidence: 99%

Recognizing psoriatic arthritis in the dermatology clinic

Garg

Gladman

2010

Journal of the American Academy of Dermatology

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“…It has been hypothesised that dactylitis in the hand may be caused by mechanical trauma to distal phalangeal and metacarpal joints. This is thought to result in an inflammatory response at the digit, known as the ‘deep Koebner’ phenomenon [ 4 , 7 , 8 ]. Toe dactylitis is more common than finger dactylitis which may support the mechanical pathogenesis hypothesis given the load bearing function of the toes, but there are no investigations to support a mechanical trigger [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…This is thought to result in an inflammatory response at the digit, known as the ‘deep Koebner’ phenomenon [ 4 , 7 , 8 ]. Toe dactylitis is more common than finger dactylitis which may support the mechanical pathogenesis hypothesis given the load bearing function of the toes, but there are no investigations to support a mechanical trigger [ 7 , 8 ]. It has also been suggested that psoriatic nail disease may be linked to micro trauma occurring within the nail bed [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Plantar forefoot pressures in psoriatic arthritis-related dactylitis: an exploratory study

et al. 2016

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Dactylitis is a common feature of psoriatic arthritis (PsA); local physical trauma has been identified as a possible contributing factor. The aim of this study was to explore differences in forefoot plantar pressures in patients with PsA with and without dactylitis and compare to healthy controls. Thirty-six participants were recruited into three groups: group A PsA plus a history of dactylitis; group B PsA, no dactylitis; group C control participants. Forefoot plantar pressures were measured barefoot and in-shoe at the left second and fourth toes and corresponding metatarsophalangeal joints. Temporal and spatial parameters were measured and data from the foot impact scale for rheumatoid arthritis (FIS-RA), EQ5D and health assessment questionnaire (HAQ) were collected. Pressure time integral peak plantar pressure, and contact time barefoot and in-shoe were not significantly different between groups. Temporal and spatial parameters reported no significant differences between groups. ANOVA analysis and subsequent post hoc testing using Games-Howell test yielded significance in FIS-RA scores between both PsA groups versus controls, A p ≤ 0.0001 and PsA group B p < 0.0001 in the FIS-RA impairment and footwear domain, PsA group A p < 0.03 and PsA group B p ≤ 0.05 in the FIS-RA activity and participation domain compared to controls. This is the first exploratory study to investigate forefoot plantar pressures in patients with and without historical dactylitis in PsA. FIS-RA scores indicate PsA patients have significant limitations compared to controls, although a history of dactylitis does not appear to worsen patient reported outcomes.

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“…PsA is an uncommon disease affecting 0.3–1% of the general population [1, 9]. Therefore, the strength of this study is the high number of patients recruited and the execution of viral serologic tests not routinely performed in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Past and Reactivated Viral Infections and Efficacy of Cyclosporine A as Monotherapy or in Combination in Patients with Psoriatic Arthritis—Synergy Study: A Longitudinal Observational Study

Colombo

Chimenti

Grossi

et al. 2014

BioMed Research International

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We have prospectively evaluated psoriatic arthritis (PsA) patients for (1) seropositivity for former viral infections and seroconversion and (2) efficacy of cyclosporine A (CsA) alone or in combination with other immunosuppressants in a time period of 12 months. Screening included HBV antibodies and antigens, HCV antibodies and RNA, HSV 1-2, HZV, EBV, and CMV IgG, and IgM, HHV-6 DNA, and HIV 1-2 antibodies. PsA was evaluated by the Psoriasis Area Severity Index (PASI), the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and the Visual Analogue Scale (VAS). At baseline, 126 (56%) out of 225 evaluable patients had 2 or more seropositivities indicative of former infections, and 31 patients (13.8%) presented seropositivity for HCV, HBV, HSV-1 and -2, HHV-6, EBV, or parvovirus infection; one of them, positive for HBAg, was treated with lamivudine, while the remaining 30 received no specific treatment. None of the 31 patients developed virus reactivation. A reduction (P < 0.001) of PASI, BASDAI, and VAS scores was observed at 6 and 12 months. The treatment of PsA with CsA as monotherapy or in combination was safe and effective. In vitro experiments and clinical findings, including those from our study, suggest that CsA as monotherapy or in combination with biologics might be the treatment of choice in PsA HCV-positive patients.

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Epidemiology of Psoriatic Arthritis

Cited by 7 publications

References 17 publications

Recognizing psoriatic arthritis in the dermatology clinic

Recognizing psoriatic arthritis in the dermatology clinic

Plantar forefoot pressures in psoriatic arthritis-related dactylitis: an exploratory study

Prevalence of Past and Reactivated Viral Infections and Efficacy of Cyclosporine A as Monotherapy or in Combination in Patients with Psoriatic Arthritis—Synergy Study: A Longitudinal Observational Study

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