Epidemiology of pulmonary embolism in today’s context: analysis of incidence, mortality and problems of their study

Никулина, Н. Н.; Тереховская, Ю В

doi:10.15829/1560-4071-2019-6-103-108

Cited by 21 publications

(3 citation statements)

References 42 publications

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“…(2S,4S)-( 4 4.41 (q, J = 9.5 Hz, 0.88H, H-4, conformer A), 5.35 (dd, J = 8.5, 7.2 Hz, 1H, H-2), 6.85-6.91 (m, 0.12H, NH, conformer B), 7.19 (t, J = 8.9 Hz, 2H, H-3 ,5 ), 7.21 (br.d, J = 9.7 Hz, 0.88H, NH, conformer A), 7.36 (dd, J = 9.0, 4.9 Hz, 2H, H-,6 ). 19 F NMR (376 MHz, DMSO-d 6 ) δ (ppm) [conformers A and B, 88:12]: 44.83-44.88 (br.m, 0.12F, F-4 , conformer B), 45.02 (tt, J = 9.0, 4.9 Hz, 0.88F, F-4 , conformer A).…”

Section: Methodsmentioning

confidence: 99%

“…Among these complications, pulmonary embolism (PE) stands out as a particularly dangerous condition, for which postoperative mortality is 10-20% [1][2][3]. In addition, PE is the third most common cardiovascular disease with a significant public health burden, affecting 250-300 thousand people annually in Europe and in the United States [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides

Krasnov,

Nizova,

Vigorov

et al. 2023

Molecules

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Venous thromboembolism is a serious problem because it significantly increases the risk of developing vascular complications in elderly patients with obesity or immobilization, cancer, and many other diseases. Thus, there is a need to study new therapeutic strategies, including new medicinal agents for the efficient and safe correction of thrombus disorders. In this work, we have synthesized a number of new amides and peptides of 4-amino-5-oxoprolines and studied their antiplatelet and antithrombotic activity in experiments in vitro and in vivo. It has been found that the newly obtained compounds slow down the process of thrombus formation in a model of arterial and venous thrombosis, without affecting plasma hemostasis parameters. (2S,4S)-4-Amino-1-(4-fluorophenyl)-5-oxoprolyl-(S)-phenylalanine proved to be the most efficient among the studied derivatives. The results obtained indicate the advisability of further studies on 5-oxoproline derivatives in order to design pharmaceutical agents for the prevention and treatment of the consequences of thrombosis.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides

Krasnov,

Nizova,

Vigorov

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…In France, the incidence of pulmonary embolism rivals that of myocardial infarction fatalities, with over 100,000 new cases reported annually [6]. The resulting disability and morbidity from PE are significant drivers of medical expenditures and bear socioeconomic implications [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

A Cyber-physical-social systems approach to the semantic segmentation of pulmonary embolism

Zhan,

Lei,

Guo

et al. 2024

Front. Phys.

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Cyber-Physical-Social Systems (CPSS) epitomize the modern era’s intelligent connectivity. They integrate physical devices, computer networks, and social networks, forming an innovative paradigm for intelligent systems. Utilizing CPSS to enhance intelligence, automation, and remote services in healthcare represents a primary research focus. Pulmonary embolism, a prevalent condition resulting from the blockage of the pulmonary artery and its branches by emboli, leads to a spectrum of clinical syndromes marked by impaired pulmonary circulation and right heart dysfunction, contributing to sudden and unpredictable fatalities. Nevertheless, the diagnosis of pulmonary embolism remains challenging due to non-specific clinical presentations, constrained diagnostic capabilities, delayed diagnoses, insufficient physician knowledge, and suboptimal diagnostic techniques. Consequently, we introduce the innovative LSCU-Net architecture within the CPSS framework, designed to develop an automated segmentation and intelligent assessment system for pulmonary embolism, facilitating its automated and intelligent detection. The experimental findings demonstrate that the model accurately segments pulmonary embolism, evidenced by a Jaccard index of 0.6958, a Dice coefficient of 0.8193, a Mean Pixel Accuracy (mPA) of 0.8519, and an accuracy of 0.9993. Empirical studies reveal that our proposed model substantially surpasses existing models in performance. Consequently, this model can aid physicians in the diagnosis of pulmonary embolism during clinical practice. The established pulmonary embolism automatic segmentation and assessment system also showcases the application successes of CPSS in intelligent remote healthcare. The system’s development and deployment not only streamline physicians’ diagnostic processes but also elevate public health standards and advance CPSS research within the medical domain.

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Pulmonary embolism and atrial fibrillation: analysis of data from the SIRENA Russian registry

et al. 2022

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Aim. To present the clinical characteristics and in-hospital prognosis in patients with pulmonary embolism (PE) and atrial fibrillation (AF).Material and methods. On the initiative of a working group of physicians, the basic principles of an observational prospective study (SIRENA registry) have been developed.Results. Among the 660 patients included in the registry, AF was diagnosed in almost every fourth patient — in 22,9% of cases (n=151), which reflects its high incidence in relation to PE. The prevalence of AF corresponded to such conditions as heart failure (HF) (23,2%; n=153), diabetes (15,6%; n=103), and hypertension (HTN) (65,7% n=400). The diagnosis of AF in most patients is based on the history data (n=144; 95,4%), while the first registered AF episode was verified in 7 patients (4,6%). Patients with AF were characterized by older age, significantly higher prevalence of HF (51,2%), HTN (80,8%), chronic kidney disease (18,5%), stroke or transient ischemic attack (23,2%). It is important to note the low prevalence of anticoagulant therapy (15,3%) in the group of patients with previously diagnosed AF (n=144). The prevalence of thrombolytic therapy in patients with AF was significantly lower than among patients without AF (13,9 vs 25,8% (p=0,026)), which is due to contraindications and underdiagnosis of PE. Given the predominantly senile age, high comorbidity rate in patients with AF, as well as the absence of outpatient anticoagulant therapy, in-hospital mortality in patients with PE and AF was 31,1%, and significantly differed from that in those without AF 12,6% (p=0,001). In the general group, post-mortem diagnosis of PE was noted in 7,7% of cases (n=51), of which the proportion of patients with AF was 54,9% (n=28). A possible explanation for the underestimation of PE in AF patients was an erroneous explanation of its manifestations (tachypnea, tachycardia, lower limb edema) due to concomitant HF.Conclusion. Suspicion for PE in elderly patients with AF and manifestations of HF decompensation, as well as the timely administration of anticoagulant therapy, will prevent both arterial and venous embolism.

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Epidemiology of pulmonary embolism in today’s context: analysis of incidence, mortality and problems of their study

Cited by 21 publications

References 42 publications

Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides

Synthesis and Assessment of Antiplatelet and Antithrombotic Activity of 4-Amino-Substituted 5-Oxoproline Amides and Peptides

A Cyber-physical-social systems approach to the semantic segmentation of pulmonary embolism

Pulmonary embolism and atrial fibrillation: analysis of data from the SIRENA Russian registry

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