Epidemiology of renal osteodystrophy in Iberoamerica

López, J. Bernardino Díaz; Jorgetti, Vanda; Caorsi, Hena; Ferreira, Aníbal; Palma, Alfonso; Menéndez, Primitiva; Olaizola, Inés; Ribeiro, Silvia Carreira; Jarava, C.; Moreira, Eleonora; Cannata-Andía, Jorge B.

doi:10.1093/ndt/13.suppl_3.41

Cited by 25 publications

(14 citation statements)

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“…Information regarding the actual prevalence of different types of RO is conflicting [14][15][16] . These discrepancies could be attributed to many factors, such as differences in the epidemiological and clinical characteristics of the CKD patients (such as age or ethnicity), availability of drugs used for the treatment of CKD-MBD, and treatment modalities among the populations studied [11][12][13][14][15][16]26,27 . However, whether a specific histological type of renal RO could result in unfavorable clinical outcomes and whether it would only mark the severity of a broader disease dissociated from outcomes is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…The available information regarding RO has mainly been derived from a series of observational studies showing a trend in the prevalence of high turnover disease, a decrease in osteomalacia, and stabilization of adynamic bone disease over the last decades 11 - 15 . A recent study observed a modification in the proportion of RO distribution, suggesting that low bone turnover disease can occur frequently during the late stages of CKD 16 .…”

Section: Introductionmentioning

confidence: 99%

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Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO

et al. 2020

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ABSTRACT Introduction: Mineral and bone disorders (MBD) are major complications of chronic kidney disease (CKD)-related adverse outcomes. The Brazilian Registry of Bone Biopsy (REBRABO) is an electronic database that includes renal osteodystrophy (RO) data. We aimed to describe the epidemiological profile of RO in a sample of CKD-MBD Brazilian patients and understand its relationship with outcomes. Methods: Between August 2015 and March 2018, 260 CKD-MBD stage 3-5D patients who underwent bone biopsy were followed for 12 to 30 months. Clinical-demographic, laboratory, and histological data were analyzed. Bone fractures, hospitalizations, and death were considered the primary outcomes. Results: Osteitis fibrosa, mixed uremic osteodystrophy, adynamic bone disease, osteomalacia, osteoporosis, and aluminum (Al) accumulation were detected in 85, 43, 27, 10, 77, and 65 patients, respectively. The logistic regression showed that dialysis vintage was an independent predictor of osteoporosis (OR: 1.005; CI: 1.001-1.010; p = 0.01). The multivariate logistic regression revealed that hemodialysis treatment (OR: 11.24; CI: 1.227-100; p = 0.03), previous parathyroidectomy (OR: 4.97; CI: 1.422-17.241; p = 0.01), and female gender (OR: 2.88; CI: 1.080-7.679; p = 0.03) were independent predictors of Al accumulation; 115 patients were followed for 21 ± 5 months. There were 56 hospitalizations, 14 deaths, and 7 fractures during follow-up. The COX regression revealed that none of the variable related to the RO/turnover, mineralization and volume (TMV) classification was an independent predictor of the outcomes. Conclusion: Hospitalization or death was not influenced by the type of RO, Al accumulation, or TMV classification. An elevated prevalence of osteoporosis and Al accumulation was detected.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO

et al. 2020

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“…Daneben besteht ein enger Zusammenhang zwischen Ausma ß der Nierenfunktionseinschr ä nkung und der Entstehung extraskelettaler Kalzifi kationen, die zu einer erh ö hten kardiovaskul ä ren Mortalit ä t f ü hren [5 -7] . Im Folgenden soll eingegangen werden auf: 1 F ü r die Entwicklung der beiden Formen einer " low turnover " Osteopathie -der Osteomalazie und der adynamen Knochenerkrankung -wurde zun ä chst eine Aluminium ü berbelastung mit Akkumulation im Knochen und Aluminium-induzierter PTH-Hyposekretion urs ä chlich verantwortlich gemacht [12] . Nach einer Reduktion der Anwendung Aluminium-haltiger Phosphatbinder und der Verwendung Aluminium-freien Dialysatwassers war die Inzidenz der Osteomalazie deutlich r ü ckl ä ufi g [13] , die Inzidenz der adynamen Knochenerkrankung dagegen aber eher ansteigend [14,15] .…”

Section: Pathogenese Derunclassified

Skelettale Komplikationen bei chronischer Niereninsuffizienz und nach Nierentransplantation

Lehmann¹,

Wolf²

2011

Akt Rheumatol

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“…In accordance with the above case, several reports have documented that there is evidence for a different preponderance of certain types of skeletal disease in different geographical locations 5 . For example, in Italy and in the UK, osteomalacia is common, 6,7 whereas osteitis fibrosa is more common in Germany, the Netherlands, and in the USA, 8–10 while in South America, a high prevalence of mixed and low bone turnover lesions was found 11 …”

Section: Introductionmentioning

confidence: 99%

Osteodystrophy in Indonesian haemodialysis patients

2003

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A preliminary study of the intact-parathyroid hormone (i-PTH) measurements from haemodialysis patients was conducted to determine the prevalence of renal bone diseases at the Dr Soetomo Hospital. The objective of this study is to evaluate the osteodystrophy renal pattern in haemodialysis patients using i-PTH and radiological parameters. The selected populations of 48 (32 males and 16 females), the mean age 48 +/- 10.3 years, was evaluated to conduct a cross-sectional study. The calorimetric method was applied to measure serum P and Ca, while a radioimmunoassay was used to assay the i-PTH level. Of those 48 patients receiving haemodialysis, with a duration ranging from 4 to 432 weeks, 61% had hypocalcaemia and 10% had hypercalcaemia. The i-PTH levels below 100 pg/mL (normal, 10-65 pg/mL) suggested 'aplastic' bone, and values of 100-200 pg/mL most commonly indicated 'normal' bone turnover. The i-PTH levels over 200 pg/mL suggested hyperparathyroidism. The results of this study demonstrated that 42% of those patients had <100 pg/mL (low turnover bone presumed, no biopsy), 23% had 100 - <200 pg/mL ('normal' bone turnover) and 35% of them had >200 pg/mL ('hyperparathyroidism'). In addition, the radiological study showed that 10% of those patients were positive for renal bone diseases. In conclusion, this study shows that the common type of renal osteodystrophy was of a low turnover type, which was different from the findings in other previous studies. It is postulated that this difference is likely to be caused by some factors such as the general health condition of the population those patients belong to and, in particular, the nutritional status of those patients.

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Epidemiology of renal osteodystrophy in Iberoamerica

Cited by 25 publications

References 3 publications

Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO

Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO

Skelettale Komplikationen bei chronischer Niereninsuffizienz und nach Nierentransplantation

Osteodystrophy in Indonesian haemodialysis patients

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