Epidemiology of rheumatic musculoskeletal disorders in the developing world

Chopra, Arvind; Abdel-Nasser, Ahmed M.

doi:10.1016/j.berh.2008.07.001

Cited by 204 publications

(125 citation statements)

References 48 publications

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“…In India, with its high prevalence of various types of infections, this problem is well recognized, and, in a large number of patients with rheumatoid factor-negative inflammatory arthritis, an exact diagnosis is often not made (1,2). In recent years, we have continued to encounter an unprecedented frequency of chronic arthritis following the Chikungunya epidemic of 2006 (3), and several of these cases are likely to satisfy the clinical and historical components of the new classification criteria reported by Aletaha et al (4).…”

Section: To the Editormentioning

confidence: 99%

A perspective from India on the 2010 rheumatoid arthritis classification criteria: Comment on the article by Aletaha et al

Chopra¹

2011

Arthritis & Rheumatism

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Section: To the Editormentioning

confidence: 99%

A perspective from India on the 2010 rheumatoid arthritis classification criteria: Comment on the article by Aletaha et al

Chopra¹

2011

Arthritis & Rheumatism

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“…It is a chronic inflammatory disease that affects over 21 million people worldwide and most of them are women (Chopra & Abdel-Nasser, 2008). RA is one of the leading causes of chronic morbidity in the developed world, and mostly affecting the work force population throughout the world (Mody, 2009).…”

Section: Introductionmentioning

confidence: 99%

Hematological and lipid profile evaluation of a hexane fraction ofCostus aferleaves in arthritic rats

Anyasor

Onajobi

Osilesi

et al. 2015

Pharmaceutical Biology

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Context: Costus afer Ker Gawl. (Costaceae) is an ethnomedical plant used as therapy against inflammatory disorders. Objective: The objective of this study was to evaluate the hematological and lipid profile analysis of hexane fraction of C. afer leaves (CAHLF) in arthritic rats. Materials and methods: Male albino rats were randomly distributed into seven groups of six rats each. Rats were induced with arthritis using formaldehyde and Complete Freund's Adjuvant (CFA) for 7 and 21 d, respectively. The animals were administered orally with 50, 100, and 250 mg/kg CAHLF, 10 mg/kg diclofenac and prednisolone, 0.9% NaCl (control), and 0.9% NaCl (normal). At the end of treatment periods, blood samples were withdrawn and subjected to hematological and biochemical analysis using auto-analyzer and spectrophotometric methods. Results: Hematological analysis revealed that in formaldehyde-and CFA-induced arthritic rat models, 250 mg/kg CAHLF-treated groups had significantly reduced (p50.05) hematocrit counts (HC) (30.98 ± 1.59% and 33.55 ± 1.10%), white blood cell counts ( /L). Furthermore, blood analysis showed that CAHLF-treated groups had reduced total cholesterol, low-density lipoprotein cholesterol, and triglycerides while they had an elevated high-density lipoprotein compared with the control group. Discussion and conclusion: Findings from this study indicated that CAHLF could possess immunomodulatory and hypolipidemic properties in arthritic rats. CAHLF could be considered as a source of biopharmaceutical agents in anti-arthritis drug discovery process.

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“…According to a report, musculoskeletal disorders contributed 3.4% and 1.7% of the total disease burden in the developed and developing world, respectively, with osteoarthritis (OA) being the single largest contributor (4). However, the burden on musculoskeletal disorders in terms of disabilityadjusted life years (DALYs) on the developing world (21,076,000 DALYs) was estimated to be almost 2.5 times that of the developed world (8,723,000 DALYs).…”

mentioning

confidence: 99%

“…However, the burden on musculoskeletal disorders in terms of disabilityadjusted life years (DALYs) on the developing world (21,076,000 DALYs) was estimated to be almost 2.5 times that of the developed world (8,723,000 DALYs). The lack of data from the developing world suggests that this figure may even be an underestimate (3,4). Using the WHO/ International League of Associations for Rheumatology Community Oriented Programme for Control of Rheumatic Diseases, a study from Egypt suggested that 16.2% of adults had musculoskeletal pain (3).…”

mentioning

confidence: 99%