Epidemiology of scabies prevalence in the U.K. from general practice records

Lassa, Samuel; Campbell, Mike; Bennett, C.E.

doi:10.1111/j.1365-2133.2011.10264.x

Cited by 59 publications

(58 citation statements)

References 29 publications

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“…However, there are studies showing no sexrelated differences [19,20]. And other studies reporting higher odds of infestation in females [21][22][23]. Interestingly, stratification of the prevalence data by sex and age in this survey showed that scabies was more prevalent in males since the youngest age classes, when differences in lifestyle are clearly far to be applicable justification.…”

Section: Discussionmentioning

confidence: 56%

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Scabies Prevalence and Risk Factors in Pakistan: A Hospital Based Survey

Chaudhry¹

2018

BJSTR

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Section: Discussionmentioning

confidence: 56%

“…And the West Bank, Palestinian Territories [19]. Similarly to [22][23][24][25]. Scabies was more prevalent in winter.…”

Section: Discussionmentioning

confidence: 99%

Scabies Prevalence and Risk Factors in Pakistan: A Hospital Based Survey

Chaudhry¹

2018

BJSTR

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“…Scabies is, in our setting, predominantly a disease of the elderly, especially in those residing in long-term-care facilities (Table 2). This pattern is echoed in some developed countries, where a high incidence of scabies among the elderly population in seen (34,35). Nevertheless, we are uncertain whether this is a genuine situation territory-wide or whether pediatric scabies patients were being managed in the primary care and outpatient settings and, hence, scabies may not have been diagnosed by our hospital-based laboratories.…”

Section: Discussionmentioning

confidence: 93%

Development of Conventional and Real-Time Quantitative PCR Assays for Diagnosis and Monitoring of Scabies

et al. 2015

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c Scabies remains the most prevalent, endemic, and neglected ectoparasitic infestation globally and can cause institutional outbreaks. The sensitivity of routine microscopy for demonstration of Sarcoptes scabiei mites or eggs in skin scrapings is only about 50%. Except for three studies using conventional or two-tube nested PCR on a small number of cases, no systematic study has been performed to improve the laboratory diagnosis of this important infection. We developed a conventional and a real-time quantitative PCR (qPCR) assay based on the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene of S. scabiei. The cox1 gene is relatively well conserved, with its sequence having no high levels of similarity to the sequences of other human skin mites, pathogenic zoonotic mites, or common house dust mite species. This mitochondrial gene is also present in large quantities in arthropod cells, potentially improving the sensitivity of a PCR-based assay. In our study, both assays were specific and were more sensitive than microscopy in diagnosing scabies, with positive and negative predictive values of 100%. The S. scabiei DNA copy number in the microscopy-positive specimens was significantly higher than that in the microscopy-negative specimens (median S. scabiei DNA copy number, 3.604 versus 2.457 log 10 copies per reaction; P ‫؍‬ 0.0213). In the patient with crusted scabies, the qPCR assay performed on lesional skin swabs instead of scrapings revealed that the parasite DNA load took about 2 weeks to become negative after treatment. The utility of using lesional skin swabs as an alternative sample for diagnosis of scabies by PCR should be further evaluated. Scabies remains a significant infectious problem worldwide and is a problem not merely in developing countries but also in the developed world. An estimated 300 million cases of scabies occur globally every year, with scabies having a particular association with young children, poor hygiene, homelessness, crowdedness, and poverty in the tropical and subtropical regions (1). The prevalence of scabies in some populations, such as Australian aborigines, can be as high as 25 to 50%, and the burden of disease and morbidity are further aggravated by complications with bacterial pyoderma, including that caused by methicillin-resistant Staphylococcus aureus (2, 3). In developed countries, scabies causes significant public health issues in vulnerable individuals, such as individuals at the extremes of ages and immunocompromised hosts. For example, an estimated incidence of 233 to 470 per 100,000 person-years was reported in a national study conducted from 1994 to 2003 in England (4). In addition, outbreaks readily occur in the community in schools, hospitals (including intensive care units), and other institutions (5-10). Among immunocompromised patients, such as HIV-infected individuals, organ transplant recipients, and patients on biologics or other immunosuppressive therapies, scabies can occur as an unrecognized complication with considerable delays in diagnosis and...

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“…Insiden di Amerika hampir mencapai 1 juta kasus per tahun. Rata-rata prevalensi kejadian scabies di Inggris adalah 2,27 per 1000 orang (laki-laki) dan 2,81 per 1000 orang (perempuan), dimana 1 dari 1000 orang datang ke pusat-pusat kesehatan dengan keluhan gatal yang menetap (Lassa, et al, 2011; (Poeranto, et al, 1997).…”

Section: Pendahuluanunclassified