Epidemiology of Sepsis Syndrome in 8 Academic Medical Centers

Sands, Kenneth

doi:10.1001/jama.1997.03550030074038

Cited by 547 publications

(247 citation statements)

References 22 publications

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“…The other studies reported a higher prevalence of sepsis in patients aged 57 years. 12 We found a slightly higher percentage of males affected with sepsis compared to females in the present study. Other studies also indicated a higher incidence in male.…”

Section: Discussioncontrasting

confidence: 45%

Procalcitonin as a marker for the diagnosis of sepsis

Chivate¹,

Belwalkar²,

Limaye³

et al. 2016

Int J Res Med Sci

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Section: Discussioncontrasting

confidence: 45%

Procalcitonin as a marker for the diagnosis of sepsis

Chivate¹,

Belwalkar²,

Limaye³

et al. 2016

Int J Res Med Sci

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“…It is an infection-initiated systemic inflammatory reaction syndrome resulting from the interactions between environmental and genetic factors. [1][2][3] Septic shock, the most severe complication of sepsis, is a deadly disease. Many mechanisms are involved in the pathophysiology of septic shock, including the release of cytokines, the activation of neutrophils, monocytes, and microvascular endothelial cells, as well as the activation of neuroendocrine reflex and plasma protein cascade systems (complement system, the intrinsic and extrinsic pathways of coagulation, and the fibrinolytic system).…”

Section: Introductionmentioning

confidence: 99%

Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and septic shock in a Chinese Han population

Peng¹,

Li²,

Zhou³

et al. 2015

World Journal of Emergency Medicine

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BACKGROUND: Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify infl ammation and serves as a critical mediator of infl ammatory response in the context of sepsis. To date, the predisposition of TREM-1 gene polymorphisms to septic shock has not been reported. This study was designed to investigate whether TREM-1 genomic variations are associated with the development of septic shock. METHODS:We genotyped two TREM-1 single nucleotide polymorphisms (SNPs, rs2234237 and rs2234246) and evaluated the relationships between these SNPs and septic shock on susceptibility and prognosis.RESULTS: TREM-1 rs2234246 A allele in the promoter region was signifi cantly associated with the susceptibility of septic shock in recessive model (AA, OR=3.10, 95%CI 1.15 to 8.32, P=0.02), and in codominant model (AG, OR=0.72, 95%CI 0.43-1.19, P=0.02; AA, OR=2.71, 95%CI 1.00-7.42; P=0.03). However, in three inherited models (dominant model, recessive model, and codominant model), none of the assayed loci was signifi cantly associated with the prognosis of septic shock. The nonsurvivor group demonstrated higher plasma IL-6 levels (99.7±34.7 pg/mL vs. 61.2±26.5 pg/mL, P<0.01) than the survivor group. Plasma concentrations of IL-6 among the three genotypes of rs2234246 were AA 99.4±48.9 pg/mL, AG 85.4±43 pg/mL, and GG 65.3±30.7 pg/mL (P<0.01). The plasma concentrations of IL-6 in patients with AA genotypes were signifi cantly higher than those in patients with GG genotypes (P<0.01).CONCLUSION: TREM-1 genetic polymorphisms rs2234246 may be significantly correlated only with susceptibility to septic shock in the Chinese Han population.

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“…1 This mortality increases when multiple organ and systemic dysfunctions occur. Although not having a wellelucidated pathogeny, this dysfunction seems to be consequent to a complex inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

et al. 2008

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PURPOSE: To study the effects of peritoneal lavage with a 2% lidocaine solution, on the survival of the rats submitted to peritonitis caused by their own feces. METHODS: Forty-eight Wistar rats, weighting between 300g and 330g (mean, 311,45 ±9,67g), were submitted to laparotomy 6 hours following induction of fecal peritonitis. Animals were randomly divided into four groups of 12 each as follows: 1- Control, no therapy; 2- Drying of the abdominal cavity; 3- Peritoneal lavage with saline and drying; 4- Peritoneal lavage with a 2% lidocaine solution and drying. Animals that died were submitted to necropsy and the time of their death recorded; survivors were killed on the post-operation 11th day and necropsied. RESULTS: Death occurred within 52 h in all animals of group 1; within 126 h in 100% of those of group 2; within 50 h in 50% of those of group 3. All animals of group 4 survived. Survival on the 11 th day was higher in groups 3 and 4 than in groups 1 and 2 (p<0.001), and higher in group 4 than in group 3 (p<0.01). CONCLUSION: Peritoneal lavage with a 2% lidocaine saline solution without adrenaline, prevented the mortality of all animals with fecal peritonitis .

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Epidemiology of Sepsis Syndrome in 8 Academic Medical Centers

Cited by 547 publications

References 22 publications

Procalcitonin as a marker for the diagnosis of sepsis

Procalcitonin as a marker for the diagnosis of sepsis

Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and septic shock in a Chinese Han population

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

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