Epidemiology of Severe Sepsis and Septic Shock

Artero, Arturo; Zaragoza, Rafael; Nogueira, José Miguel

doi:10.5772/27208

Cited by 14 publications

(12 citation statements)

References 32 publications

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“…At least 40 patients who developed sepsis after study enrolment were planned to be included. Based on recently published data [ 17 – 19 ], the expected incidence of sepsis in the targeted ICU population was estimated conservatively to be 15%. This value corresponded to a sample of 267 patients, to which we added 10% to compensate for withdrawal and loss to follow-up.…”

Section: Study Design and Methodsmentioning

confidence: 99%

Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

et al. 2021

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Background The early recognition and management of sepsis improves outcomes. Biomarkers may help in identifying earlier sub-clinical signs of sepsis. We explored the potential of serial measurements of C-reactive protein (CRP), procalcitonin (PCT) and pancreatic stone protein (PSP) for the early recognition of sepsis in patients hospitalized in the intensive care unit (ICU). Methods This was a multicentric international prospective observational clinical study conducted in 14 ICUs in France, Switzerland, Italy, and the United Kingdom. Adult ICU patients at risk of nosocomial sepsis were included. A biomarker-blinded adjudication committee identified sepsis events and the days on which they began. The association of clinical sepsis diagnoses with the trajectories of PSP, CRP, and PCT in the 3 days preceding these diagnoses of sepsis were tested for markers of early sepsis detection. The performance of the biomarkers in sepsis diagnosis was assessed by receiver operating characteristic (ROC) analysis. Results Of the 243 patients included, 53 developed nosocomial sepsis after a median of 6 days (interquartile range, 3–8 days). Clinical sepsis diagnosis was associated with an increase in biomarkers value over the 3 days preceding this diagnosis [PSP (p = 0.003), PCT (p = 0.025) and CRP (p = 0.009)]. PSP started to increase 5 days before the clinical diagnosis of sepsis, PCT 3 and CRP 2 days, respectively. The area under the ROC curve at the time of clinical sepsis was similar for all markers (PSP, 0.75; CRP, 0.77; PCT, 0.75). Conclusions While the diagnostic accuracy of PSP, CRP and PCT for sepsis were similar in this cohort, serial PSP measurement demonstrated an increase of this marker the days preceding the onset of signs necessary to clinical diagnose sepsis. This observation justifies further evaluation of the potential clinical benefit of serial PSP measurement in the management of critically ill patients developing nosocomial sepsis. Trial registration The study has been registered at ClinicalTrials.gov (no. NCT03474809), on March 16, 2018. https://www.clinicaltrials.gov/ct2/show/NCT03474809?term=NCT03474809&draw=2&rank=1.

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Section: Study Design and Methodsmentioning

confidence: 99%

Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

et al. 2021

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“…pneumonia; and and the most common gram-positive bacteria were S. aureus, S. pneumonia and Enterococcus spp. in patients with sepsis and septic shock (28). In our study, the most common gram-negative bacteria were P. aeruginosa, A. Baumannii, K. Pneumoniae and Enterobacter spp; and the most common gram-positive bacteria were S. epidermidis, S. aureus and S. hominis ssp hominis in the blood culture.…”

Section: Discussionmentioning

confidence: 49%

Evaluation of the Effectiveness of Continuous Venovenous Hemodiafiltration Appli̇ed With Oxiris and AN69 Membranes in Patients With Septic Shock-Related Acute Kidney Injury

Kaçar¹,

Uzundere²,

Yüksel³

et al. 2020

Preprint

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Background and objectives: AN69 and Oxiris are filters used in continuous renal replacement therapy. In this study, we aimed to research the effects of these filters on blood cell counts, blood biochemistry, inflammation indicators, clinical status and mortality of patients diagnosed with septic shock-related acute kidney injury. Method: Between March 2019 and October 2019, 42 adult patients (Group 1: Oxiris (n = 21) or Group 2: AN69 (n=21)) with septic shock-related acute kidney injury and received continuous venovenous hemodiafiltration (CVVHDF) in the intensive care unit were included in the study and their results were prospectively observed and compared. The data at the begining of CVVHDF (pre-CVVHDF) and 24 hours after the onset of CVVHDF (post-CVVHDF) were recorded.Results: In the comparison of the pre- and post-CVVHDF values in Group 1, there was a statistically significant decrease detected in the procalcitonin (p = 0.04) and noradrenaline infusion rate (p = 0.02) levels. In terms of the other data there was no statistically significant difference between pre- and post-CVVHDF values in Group 1. In the comparison of the pre- and post-CVVHDF values in Group 2, there was a statistically significant decrease detected in the urea (p = 0.04), platelet count (p = 0.02) and procalcitonin (p = 0.002) levels. There was no statistically significant difference between pre- and post-CVVHDF values in terms of the other data in Group 2. There was no statistically significant difference between the groups in terms of mortality. Conclusions: CVVHDF with Oxiris filter causes a statistically significant decrease in noradrenaline infusion rate. Therefore, we think that the use of CVVHDF with Oxiris filter applied for septic shock-related acute kidney injury will save us time and increase the improvement in the treatment.

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“…In a review published in 2012, the most common isolated gram-negative bacteria were E. coli, P. aeruginosa and K. pneumonia; and and the most common gram-positive bacteria were S. aureus, S. pneumonia and Enterococcus spp. in patients with sepsis and septic shock (32). In our study, the most common gram-negative bacteria were P. aeruginosa, A. baumannii, K. pneumoniae and Enterobacter spp; and the most common grampositive bacteria were S. epidermidis, S. aureus and S. hominis ssp hominis in the blood culture.…”

Section: Discussionmentioning

confidence: 51%

Evaluation Of The Effectiveness Of Continuous Venovenous Hemodiafiltration Applied With Oxiris And An69 Membranes In Patients With Septic Shock-Related Acute Kidney Injury

Kaçar¹,

Uzundere²,

Yüksel³

et al. 2020

GKDA Derg

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Epidemiology of Severe Sepsis and Septic Shock

Cited by 14 publications

References 32 publications

Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study

Evaluation of the Effectiveness of Continuous Venovenous Hemodiafiltration Appli̇ed With Oxiris and AN69 Membranes in Patients With Septic Shock-Related Acute Kidney Injury

Evaluation Of The Effectiveness Of Continuous Venovenous Hemodiafiltration Applied With Oxiris And An69 Membranes In Patients With Septic Shock-Related Acute Kidney Injury

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