Epidemiology of spinal cord injury in China: A systematic review of the chinese and english literature

Chen, Chuandong; Qiao, Xu; Liu, Wei; Fekete, Christine; Reinhardt, Jan D.

doi:10.1038/s41393-022-00826-6

Cited by 38 publications

(29 citation statements)

References 19 publications

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“…The annual SCI incidence rate in the United States is about 40/1 million, and in Europe, it is 13.9-19.4/1 million[ 2 , 3 ]. A systematic review reported that the incidence of SCI in China ranged between 14.6% to 60.6%[ 4 ]and this indicated that the incidence of SCI in China is higher than that in developed countries and regions.…”

Section: Introductionmentioning

confidence: 99%

Rehabilitation care of patients with neurogenic bladder after spinal cord injury: A literature review

Xiang¹,

Li²,

Xie³

et al. 2023

World J Clin Cases

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This article reviews the research progress of rehabilitation treatment and nursing care of patients with neurogenic bladder after spinal cord injury, in order to provide reference for the rehabilitation treatment and nursing care of patients. We reviewed recent medical literature on patients with neurogenic bladder, focusing on neurogenic bladder caused by spinal cord injury. We analyzed 30 recent of publications in patients with neurogenic bladder after spinal cord injury, in addition to reviewing and evaluating the commonly used rehabilitation nursing methods for neurogenic bladder. Psychological counseling is a vital aspect which cannot be neglected in the process of neurogenic bladder rehabilitation. Hitherto, the commonly used drug and surgical treatments may have negatively impacted the mental health of patients in varying degrees. However, in clinical practice, applying intermittent catheterization in patients who have neurogenic bladder with spinal cord injury may help improve patients’ life quality, mitigate psychological burden, and reduce negative emotions.

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Section: Introductionmentioning

confidence: 99%

Rehabilitation care of patients with neurogenic bladder after spinal cord injury: A literature review

Xiang¹,

Li²,

Xie³

et al. 2023

World J Clin Cases

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“…According to a recent integrated review, the incidence of SCI varies from 14.6 to 60.6 per million each year in China (Chen et al 2022). SCI results in damage to the central or peripheral nervous system due to abnormal compression of the spinal cord, which is normally the most severe pathological consequence, along with other damage, such as vessel injury and subsequent harmful chemical release (Kjell and Olson 2016;Yokota et al 2019).…”

Section: Accepted M Manuscript 1 Introductionmentioning

confidence: 99%

Alleviation of Spinal Cord Injury by MicroRNA 137-Overexpressing Bone Marrow Mesenchymal Stem Cell-Derived Exosomes

Shao

Wang

Liu

et al. 2023

Tohoku J. Exp. Med.

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“…The neuroinflammation and neuronal apoptosis caused by SCI could continue for a couple of weeks or even longer 23,24 , but MSC-EXOs could not be continuously delivered to SCI lesions by these methods. Moreover, direct transplantation of MSC-EXOs into the spinal injury site might damage the nearby healthy tissue adjacent to the lesion, cause unpredictable side effects and increase medical accidents [25][26][27][28][29][30][31] . Therefore, in clinical practice, the direct transplantation of MSC-EXOs or materials containing MSC-EXOs into the spinal lesion of an acute SCI patient is not suited for ethical approval 32 .…”

Section: Introductionmentioning

confidence: 99%

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

Fang

Wang

Guan

et al. 2022

Preprint

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1.AbstractThe transplantation of mesenchymal stem cells-derived exosomes (MSC-EXO) has been suggested as an efficacious treatment to suppress SCI-triggered neuroinflammation. However, an ethically acceptable method to continuously deliver MSC-EXO into the acute spinal lesion without damaging spared tissues/axons has never been achieved. In this study, we fabricated a device that consists of a patch containing MSC and microneedle array (MN-MSC patch) to treat severe SCI. When topically applied to the acute spinal lesion beneath spinal dura, the soft microneedle (MN) array with good mechanical strength avoids damages to the spared spinal tissues and the porous microstructure of MN facilitates highly efficient MSC-EXO delivery. With the capacity to sustainedly deliver MSC-EXO, the MN-MSC patch was evaluated in a contusive rat SCI model and showed that the MSCs encapsulated in the patch could survive for at least 7 days, which covers the optimal time window for down-regulating SCI-triggered neuroinflammation. As a result, the MN-MSC patch treatment leads to reduced cavity and scar tissue formation, angiogenesis, and the survival of spared tissues/axons. Remarkably, the rats treated by this method achieved superior muscle control and exhibited robust hindlimb locomotion functional recovery. Conclusively, the MN-MSC patch device proposed here breaks through the current dilemma from the contradiction between treatment efficacy and ethical issues in treating acute SCI.

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Epidemiology of spinal cord injury in China: A systematic review of the chinese and english literature

Cited by 38 publications

References 19 publications

Rehabilitation care of patients with neurogenic bladder after spinal cord injury: A literature review

Rehabilitation care of patients with neurogenic bladder after spinal cord injury: A literature review

Alleviation of Spinal Cord Injury by MicroRNA 137-Overexpressing Bone Marrow Mesenchymal Stem Cell-Derived Exosomes

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

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