Epidemiology of sporotrichosis in Venezuela

Mata-Essayag, Sofía; Delgado, A.; Colella, María Teresa; Landaeta-Nezer, Maria Eugenia; Roselló, Arantza; Salazar, Cruz; Olaizola, Carolina; Hartung, C.; Magaldi, Sylvia; Velasquez, Etna

doi:10.1111/j.1365-4632.2012.05849.x

Cited by 27 publications

(29 citation statements)

References 39 publications

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“…In our study, we found that, among the subcutaneous mycoses found in Peru, sporotrichosis was the most common and mainly located throughout highlands of Peru (Apurimac, Cajamarca, La Libertad, and Cusco). There is little doubt that sporotrichosis remains a major cause of morbidity in developing nations, such as Peru, Mexico, Brazil, Colom‐bia, and Venezuela, and our study here of sporotrichosis in Peru confirms the known distribution of sporotrichosis as well as the geographical areas where sporotrichosis has historically been a health problem. Therefore, healthcare providers should remain alert to the possibility that sporotrichosis may occur in 13 geographic foci in Peru, particularly in the regions of Apurimac, Cajamarca, La Libertad, and Cusco.…”

Section: Discussionsupporting

confidence: 78%

Subcutaneous mycoses in Peru: a systematic review and meta‐analysis for the burden of disease

BSc

Málaga

2017

Int J Dermatology

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Section: Discussionsupporting

confidence: 78%

Subcutaneous mycoses in Peru: a systematic review and meta‐analysis for the burden of disease

BSc

Málaga

2017

Int J Dermatology

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“…Sporotrichosis is an endemic mycosis in some regions of the world [4][5][6][7][8]. Moreover, it has re-emerged in recent years with distinct patterns of transmission.…”

Section: Discussionmentioning

confidence: 99%

The impact of sporotrichosis in HIV-infected patients: a systematic review

2015

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Sporotrichosis is a fungal infection of man and animals caused by Sporothrix complex. It usually presents as a lymphocutaneous form, but disseminated disease may occur. Given the paucity of data about HIV/AIDS and sporotrichosis co-infection, a systematic review of reported cases of HIV-associated sporotrichosis found via Pubmed (1984-2013) was done. A total of 39 papers were included, and 58 patients' data analyzed. Thirty-three (56.9 %) cases were from Brazil and 18 (31 %) from the USA. Patients' mean age was 37.8 ± 10.4 years; males predominated (84.5 %). The median CD4(+) cell count was 97 cells/mm(3). The most common clinical forms were disseminated and disseminated cutaneous with 33 (56.9 %) and 10 (17.5 %) patients, respectively. There was a correlation between CD4(+) count and clinical categories (p = 0.002). Mortality was 30 % and there was a correlation between central nervous system involvement and death (p < 0.001).

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“…It was first described in 1935, nevertheless the exact prevalence in the country is unknown [24]. According to conventional mycological procedures, as well as epidemiological data, all isolates related to sporotrichosis have been identified as Sporothrix schenckii .…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of human sporotrichosis in Venezuela reveals high frequency of Sporothrix globosa

et al. 2015

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BackgroundSporotrichosis is a cutaneous and subcutaneous fungal disease of humans and other mammals, known to be caused by the Sporothrix schenckii species complex, which comprises four species of clinical importance: S. brasiliensis, S. globosa, S. luriei, and S. schenckii sensu stricto. Of them, S. globosa and S. schenckii s. str. show global distribution and differences in global frequency as causal agents of the disease. In the Americas, only three species are present: S. schenckii s. str., S. brasiliensis (so far, only reported in Brazil), and S. globosa. In Venezuela, since the first case of sporotrichosis reported in 1935, S. schenckii have been considered its unique etiological agent. In the present work, the presence of more than one species in the country was evaluated.MethodsBy phenotypic key features and molecular phylogeny analyses, we re-examined 30 isolates from diverse Venezuelan regions belonging to the fungi collection of Instituto de Biomedicina, Caracas, Venezuela, and national reference center for skin diseases. All isolates were collected between 1973 and 2013, and maintained in distilled water.ResultsSporotrichosis in Venezuela is mainly caused by S. schenckii s. str. (70%). However, a significant proportion (30%) of sporotrichosis cases in the country can be attributable to S. globosa. A correlation between intraspecific genotypes and clinical presentation is proposed.ConclusionsOur data suggest that sporotrichosis various clinical forms might be related to genetic diversity of isolates, and possibly, to diverse virulence profiles previously reported in the S. schenckii species complex. Sporothrix globosa was found to be the causative agent of 30% of sporotrichosis for the Venezuelan cases re-examined, the highest frequency of this species so far reported in the Americas. The high genetic variability presented by S. schenckii s. str. indicates that species distinction based on phenotypic key features could be a challenging and uncertain task; molecular identification should be always employed.

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Epidemiology of sporotrichosis in Venezuela

Cited by 27 publications

References 39 publications

Subcutaneous mycoses in Peru: a systematic review and meta‐analysis for the burden of disease

Subcutaneous mycoses in Peru: a systematic review and meta‐analysis for the burden of disease

The impact of sporotrichosis in HIV-infected patients: a systematic review

Molecular epidemiology of human sporotrichosis in Venezuela reveals high frequency of Sporothrix globosa

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