Participation in youth soccer in the United States continues to increase steadily, with a greater percentage of preadolescent participants than perhaps any other youth sport. Despite the wide-ranging health benefits of participation in organized sports, injuries occur and represent a threat to the health and performance of young athletes. Youth soccer has a greater reported injury rate than many other contact sports, and recent studies suggest that injury rates are increasing. Large increases in the incidence of concussions in youth soccer have been reported, and anterior cruciate ligament injuries remain a significant problem in this sport, particularly among female athletes. Considerable new research has identified a number of modifiable risk factors for lower-extremity injuries and concussion, and several prevention programs have been identified to reduce the risk of injury. Rule enforcement and fair play also serve an important role in reducing the risk of injury among youth soccer participants. This report provides an updated review of the relevant literature as well as recommendations to promote the safe participation of children and adolescents in soccer. Soccer is the most popular youth sport in the world and is 1 of the most popular team sports in the United States. 1 It is estimated that 3.9 million children and adolescents participate in soccer annually, 2 and from 1990 to 2014, the number of youth officially registered with US youth soccer programs increased by almost 90%. 3 Despite the wide-ranging health benefits of participation in organized sports, injuries occur and represent a threat to both athlete health and performance. 4 Unfortunately, recent studies suggest that injury rates in youth soccer may be increasing. Sportsrelated injuries represent a significant and increasing economic burden to the health care system, and the prevention of sports-related injuries in children has far-reaching health and economic benefits to the patient, the family, and the health care system as a whole. Given the number of children and youth participating in youth soccer, reducing the risk of injury among such a large group of participants has the potential to reduce attrition rates, promote lifelong participation in sport, and facilitate the