Epidemiology of Takotsubo Cardiomyopathy: A New Jersey Statewide Study

Charalambous, Marinos; David, Alice; Moreyra, Abel E.; Cosgrove, Nora M.; Kostis, John B.

doi:10.1016/s0735-1097(15)60922-6

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“…Though the first case was reported in Japan, today, TTC is geographically widespread and has been reported in all six continents [7]. It has been reported in more than 50 countries with little variation in its clinical expression.…”

Section: Introductionmentioning

confidence: 99%

Takotsubo Cardiomyopathy: Medical and Psychiatric Aspects. Role of Psychotropic Medications in the Treatment of Adults with “Broken Heart” Syndrome

Zvonarev

2019

Cureus

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Takotsubo cardiomyopathy (TTC) is reversible stress-induced cardiomyopathy featuring symptoms of acute myocardial infarction without significant coronary artery abnormalities. TTC is frequently precipitated by stressful emotional events but it also has been reported as a result of substance withdrawal, non-cardiac events, and dangerous drug-to-drug interaction. The plasma levels of both epinephrine and norepinephrine were significantly elevated in TTC patients, suggesting that elevated catecholamine levels might be the main contributing factor. However, the mechanisms underlying susceptibility to development and recurrence are not completely understood. It has been suggested that even a therapeutic dose of antidepressant could be a cause of drug-induced tachycardia and TTC. Moreover, some cases have been reported in which the development of TTC was associated with the serotonin syndrome, neuroleptic malignant syndrome, and similar fatal consequences. The aim of this article is to explore the association between underlying psychiatric disorders and TTC and to determine the role of various psychotropic medications in the progression of stress-induced cardiomyopathy. This article also notes and discusses the current theories underlying the pathophysiology of TTC. This review suggests a serious side effect of antidepressants, and to avoid life-threatening cardiovascular events, such as TTC, for patients with affective and anxiety disorders, prior screening for cardiovascular conditions by ECG with close monitoring might be necessary.

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Section: Introductionmentioning

confidence: 99%

Takotsubo Cardiomyopathy: Medical and Psychiatric Aspects. Role of Psychotropic Medications in the Treatment of Adults with “Broken Heart” Syndrome

Zvonarev

2019

Cureus

View full text Add to dashboard Cite

show abstract

Epidemiology of Takotsubo Cardiomyopathy: A New Jersey Statewide Study

Cited by 1 publication

References 0 publications

Takotsubo Cardiomyopathy: Medical and Psychiatric Aspects. Role of Psychotropic Medications in the Treatment of Adults with “Broken Heart” Syndrome

Takotsubo Cardiomyopathy: Medical and Psychiatric Aspects. Role of Psychotropic Medications in the Treatment of Adults with “Broken Heart” Syndrome

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