Epidemiology of the Infected Total Knee Arthroplasty: Incidence, Causes, and the Burden of Disease

Rodríguez-Merchán, E. Carlos; Liddle, Alexander D.

doi:10.1007/978-3-319-66730-0_1

Cited by 3 publications

(5 citation statements)

References 34 publications

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“…SSI or PJI after primary TKA requires additional debridement surgery or two-staged revisional arthroplasty, which results in a longer hospital stay, increased morbidity and mortality, and a consequent socioeconomic burden [ 1 , 2 , 3 , 4 , 5 , 7 , 41 ]. Efforts to reduce the incidence rates of PJI and SSI after TKA have become increasingly important, and a thorough understanding of modifiable risk factors is essential.…”

Section: Discussionmentioning

confidence: 99%

“…Efforts to reduce the incidence rates of PJI and SSI after TKA have become increasingly important, and a thorough understanding of modifiable risk factors is essential. Compared with the various patient-related risk factors, such as obesity, diabetes mellitus, and history of operation, operative time is easily assessable and potentially modifiable [ 4 , 5 , 6 , 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Periprosthetic joint infection (PJI) stands as one of the most severe complications of primary total knee arthroplasty (TKA), often resulting in catastrophic consequences [ 1 , 2 , 3 , 4 , 5 ]. Established risk factors for PJI include elevated body mass index, diabetes mellitus, urinary tract infections, allogenic blood transfusion, and rheumatoid arthritis [ 4 , 5 , 6 , 7 , 8 ]. However, these factors are largely non-modifiable, particularly in patients with severe arthritis, for whom surgery should not be delayed.…”

Section: Introductionmentioning

confidence: 99%

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Greater Risk of Periprosthetic Joint Infection Associated with Prolonged Operative Time in Primary Total Knee Arthroplasty: Meta-Analysis of 427,361 Patients

Shin,

Kim,

Han

2024

JCM

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Background/Objectives: Periprosthetic joint infection (PJI) is a severe complication in total knee arthroplasty (TKA) with catastrophic outcomes. The relationship between prolonged operative times and PJI remains debated. This meta-analysis investigated the link between prolonged operative times and the risk of PJI in primary TKA. Methods: A comprehensive search of the MEDLINE/PubMed, Cochrane Library, and EMBASE databases was conducted to identify studies comparing the incidence of PJI in TKAs with prolonged versus short operative times, as well as those comparing operative times in TKAs with and without PJI. Pooled standardized mean differences (SMD) in operative times between groups with and without PJI or surgical site infections (SSI), including superficial SSIs and PJIs, were analyzed. Additionally, the pooled odds ratios (OR) for PJI in TKAs with operative times exceeding 90 or 120 min were examined. Results: Seventeen studies involving 427,361 patients were included. Significant differences in pooled mean operative times between the infected and non-infected TKA groups were observed (PJI, pooled SMD = 0.38, p < 0.01; SSI, pooled SMD = 0.72, p < 0.01). A higher risk of PJI was noted in surgeries lasting over 90 or 120 min compared to those of shorter duration (90 min, pooled OR = 1.50, p < 0.01; 120 min, pooled OR = 1.56, p < 0.01). Conclusions: An association between prolonged operative time and increased risk of PJI in primary TKA has been established. Strategies for infection prevention should encompass thorough preoperative planning aimed at minimizing factors that contribute to prolonged operative times.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Greater Risk of Periprosthetic Joint Infection Associated with Prolonged Operative Time in Primary Total Knee Arthroplasty: Meta-Analysis of 427,361 Patients

Shin,

Kim,

Han

2024

JCM

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“…Implant-related surgical site infection is one of the main reasons for implant failure in orthopedics and trauma following medical implant surgery. It leads to high economic and social costs due to the hospital prolonged to stay of patients and often the need implant replacement with a burden on the health care facilities [84,85]. The prosthetic joint infection affects between 0.5% and 15% of patients undergoing primary or revision joint arthroplasty [1].…”

Section: Antimicrobial Coatingsmentioning

confidence: 99%

Surface Modifications for Implants Lifetime extension: An Overview of Sol-Gel Coatings

Tranquillo

Bollino

2020

Coatings

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The limited lifetime of implants entails having patients undergo replacement surgeries, several times throughout life in young patients, with significant risks for them and extensive cost for healthcare service. The overcoming of such inconvenience is still today a hard challenge for the scholars of the biomedical and biomaterial fields. The improvement of the currently employed implants through surface modification by coatings application is the main strategy proposed to avoid implants failure, and the sol-gel coating is an ideal technology to achieve this goal. Therefore, the present review aims to provide an overview of the most important problems leading to implant failure, the sol-gel coating technology, and its use as a strategy to overcome such issues.

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“…At 30 days, the overall percentage of surgical site infection is 1.1%, whereas the published rate of deep infection is 0.1%. The lifetime frequency of PJI after TKA ranges from 0.7% to 4.6% [18].…”

Section: Periprosthetic Joint Infectionmentioning

confidence: 99%

Revision Total Knee Arthroplasty: Epidemiology and Causes

Rodríguez-Merchán

Encinas-Ullán

Gómez-Cardero

2019

Revision Total Joint Arthroplasty

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Epidemiology of the Infected Total Knee Arthroplasty: Incidence, Causes, and the Burden of Disease

Cited by 3 publications

References 34 publications

Greater Risk of Periprosthetic Joint Infection Associated with Prolonged Operative Time in Primary Total Knee Arthroplasty: Meta-Analysis of 427,361 Patients

Greater Risk of Periprosthetic Joint Infection Associated with Prolonged Operative Time in Primary Total Knee Arthroplasty: Meta-Analysis of 427,361 Patients

Surface Modifications for Implants Lifetime extension: An Overview of Sol-Gel Coatings

Revision Total Knee Arthroplasty: Epidemiology and Causes

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