Epidemiology of the non-Hodgkin’s lymphomas: Distributions of the major subtypes differ by geographic locations

Anderson, Jane; Armitage, Jamés O.; Weisenburger, DD

doi:10.1023/a:1008265532487

Cited by 613 publications

(335 citation statements)

References 13 publications

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“…The relative incidence of the subtypes of NHL is also known to differ according to the geographical location [13,14,15]. From a cohort of 1,403 cases of NHL at nine study sites around the world that consisted of consecutive patients seen between 1988 and 1990, 31% presented as DLBCL, and 22% as follicular lymphomas.…”

Section: Discussionmentioning

confidence: 99%

“…From a cohort of 1,403 cases of NHL at nine study sites around the world that consisted of consecutive patients seen between 1988 and 1990, 31% presented as DLBCL, and 22% as follicular lymphomas. In a second major study, as part of a clinical evaluation of the International Lymphoma Study Group (ILSG), 1,378 NHL were classified from eight different geographic sites (Omaha, USA; Vancouver, Canada; Cape town, South Africa; London, UK; Würzburg/Göttingen, Germany; Lyon, France; Locarno/Bellinzona, Switzerland; and Hong Kong, China) [14]. Substantial differences were found in the distribution of the major subtypes of NHL: A greater percentage of follicular lymphoma was seen in North America, UK and South Africa (31%) versus only 14% in other sites.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological Features of Extranodal Lymphomas: Kuwait Experience

et al. 2004

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A total of 935 patients with extranodal non-Hodgkin lymphoma (NHL) diagnosed in the period between January 1985 and December 2000 in Kuwait Cancer Center, serving the whole population of Kuwait, were used to describe the clinicopathological and epidemiological features of extranodal lymphomas in Kuwait. Extranodal lymphomas accounted for 45% of all NHL observed during this time. All NHL cases from Kuwait Cancer registry were analyzed and pathologically reclassified using the latest WHO (2000) classification. The most common lymphoma observed was diffuse large B-cell lymphoma (58.60%) followed by Burkitt´s lymphoma (BL) (3.80%). In the pediatric group, BL comprises more than two thirds of all patients (77.20%). The most common extranodal sites were stomach (19.70%) and skin (17.80%) in the adult group, large intestine (29.80%) and small intestine (19.30%) in the pediatric age group. The majority (73.40%) of adult extranodal lymphomas was in stage IE–IIE and had a very good prognosis. On the contrary, the majority of pediatric extranodal lymphomas were found to be in stage III and IV. Variations in treatment policies (single agent or combined chemotherapy, radiotherapy, combined modality treatment) adopted and changed during the time period of 16 years of this retrospective study were documented.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features of Extranodal Lymphomas: Kuwait Experience

et al. 2004

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“…Although the increasing incidence of NHL is largely unexplained, epidemiologic studies indicate that immunosuppression, genetics, viruses, medical conditions, pesticides, solvents, hair dyes and diet may play an important role in the etiology of this disease [1, 2]. Furthermore there are distinct geographic as well as anatomic variations in the histopathologic subtypes of lymphomas [3, 4]. …”

Section: Introductionmentioning

confidence: 99%

“…As a consequence, new lymphoma classification systems such as the Revised European-American (REAL) and the preliminary World Health Organization (WHO) classifications of lymphoid neoplasms have been proposed [7, 8, 9]. Experience over the last few years has shown that the application of the REAL/WHO classification [3, 10, 11, 12]provided useful information about the geographic distribution of the NHL subtypes.…”

Section: Introductionmentioning

confidence: 99%

Non-Hodgkin’s Lymphomas in Greece according to the WHO Classification of Lymphoid Neoplasms

et al. 2005

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The purpose of this retrospective study, the largest unselected series in our country, was to illustrate the clinicopathological features of non-Hodgkin’s lymphoma (NHL) classified according to the World Health Organization (WHO) classification of lymphoid neoplasms. A retrospective analysis was conducted and clinical features of histological subtypes were established in 810 patients (age ≧15 years) with NHL who were treated at 8 major centers representative of Greece. There were 435 males and 375 females 95% of them aged >30 years. B symptoms were present in 34% of the patients, while 45.3% had stages I–II and 54.6% had stages III–IV. LDH was increased in 37% of the patients. B cell lymphomas formed 88% of the cases whereas T cell lymphomas formed 12% of the total. Indolent lymphomas accounted for 31.1%, aggressive ones for 66.7% and very aggressive ones for 2.4% of all NHLs. Among indolent lymphomas extranodal ones (MALT B cell lymphoma) were the most common subset while follicular lymphoma grade I and II and small lymphocytic ones presented with equal frequency. Among the aggressive lymphomas diffuse large cell lymphoma (DLCL) was the most common subtype; this entity along with large-cell immunoblastic lymphomas accounted for 45.2% of all B cell lymphomas. Among the T cell lymphomas, peripheral T cell lymphomas and anaplastic large cell lymphomas of the T/null-cell type were the most common subtypes. The most common extranodal presentation was the gastrointestinal tract (GI). Next in frequency were primary extranodal NHL of the head and neck region. MALT B cell lymphomas were found in almost half of the patients with GI tract NHL, whereas in all other extranodal places DLCL was the predominant histological subtype. The median survival for indolent and aggressive NHL was 123.5 and 55.5 months, respectively. This is the first report of a large series of malignant lymphomas in Greece using the WHO classification. It appears that there are no significant differences between NHL in Greece and other large series as far as clinical and extranodal presentation is concerned. The frequency of follicular lymphoma in the current study is comparable to that reported from Asian countries and mainland Europe, but lower than that of US and Northern European series. There were no important differences in the incidence of the remaining histological subtypes between Greece and other European countries.

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“…M antle cell lymphoma (MCL) is an aggressive tumor that accounts for Ϸ6% of all non-Hodgkin lymphoma cases in the U.S., with higher rates in North America (1,2). Although the median survival of MCL patients is only 3 years, some individuals survive Ͼ10 years from the time of diagnosis (2,3).…”

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confidence: 99%

Mutation and genomic deletion status of ataxia telangiectasia mutated ( ATM ) and p53 confer specific gene expression profiles in mantle cell lymphoma

Greiner

Dasgupta

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

144

101

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Although mantle cell lymphoma (MCL) frequently harbors inactivated ataxia telangiectasia mutated (ATM) and p53 alleles, little is known about the molecular phenotypes caused by these genetic changes. We identified point mutations and genomic deletions in these genes in a series of cyclin D1-positive MCL cases and correlated genotype with gene expression profiles and overall survival. Mutated and͞or deleted ATM and p53 alleles were found in 56% (40͞72) and 26% (21͞82) of the cases examined, respectively. Although MCL patients with inactive p53 alleles showed a significant reduction in median overall survival, aberrant ATM status did not predict for survival. Nevertheless, specific gene expression signatures indicative of the mutation and genomic deletion status of each gene were identified that were different from wild-type cases. These signatures were comprised of a select group of genes related to apoptosis, stress responses, and cell cycle regulation that are relevant to ATM or p53 function. Importantly, we found the molecular signatures are different between cases with mutations and deletions, because the latter are characterized by loss of genes colocalized in the same chromosome region of ATM or p53. This information on molecular phenotypes may provide new areas of investigation for ATM function or may be exploited by designing specific therapies for MCL cases with p53 aberrations.cancer ͉ cell cycle ͉ genetics ͉ microarray ͉ signature M antle cell lymphoma (MCL) is an aggressive tumor that accounts for Ϸ6% of all non-Hodgkin lymphoma cases in the U.S., with higher rates in North America (1, 2). Although the median survival of MCL patients is only 3 years, some individuals survive Ͼ10 years from the time of diagnosis (2, 3). There is considerable interest in defining the molecular basis for this clinical heterogeneity to develop better prognostic markers and more effective therapies.MCL corresponds to B cells of the mantle zone of the lymphoid follicles that have acquired distinctive alterations in genes related to cell cycle control and apoptosis (4). The hallmark of these genetic alterations is the t(11;14)(q13;q32) translocation that juxtaposes the IGH locus near the CCND1 gene, resulting in the overexpression of cyclin D1 (5). A subset of MCL cases acquire p53 mutations, and these patients have a significantly shortened median survival relative to cases with wild-type p53 (6-8). Interestingly, the ataxia telangiectasia mutated (ATM) gene, whose product regulates some p53-dependent apoptosis pathways, is mutated or deleted in 25-40% of MCL cases (reviewed in refs. 9 and 10). Although preliminary studies suggest that ATM mutation status does not have a significant impact on patient survival (7, 11), they may have lacked the statistical power to identify more subtle effects on survival, such as the effect of functional subsets of mutations.We determined the ATM and p53 genotypes in a large cohort of MCL cases with previous gene expression profiles to further elucidate the relationship between molecular phe...

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Epidemiology of the non-Hodgkin’s lymphomas: Distributions of the major subtypes differ by geographic locations

Abstract: Our study provides evidence that the distribution of NHL subtypes differs by geographic region. These findings suggest that geographical differences in etiologic or host factors may be responsible for the observed differences in the distribution of cases across NHL subtypes.

Cited by 613 publications

References 13 publications

Clinicopathological Features of Extranodal Lymphomas: Kuwait Experience

Clinicopathological Features of Extranodal Lymphomas: Kuwait Experience

Non-Hodgkin’s Lymphomas in Greece according to the WHO Classification of Lymphoid Neoplasms

Mutation and genomic deletion status of ataxia telangiectasia mutated ( ATM ) and p53 confer specific gene expression profiles in mantle cell lymphoma

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