Epidemiology of Visceral Mycoses: Analysis of Data in
            <i>Annual of the Pathological Autopsy Cases in Japan</i>

Yamazaki, Toshikazu; Kume, Hikaru; Murase, Setsuko; Yamashita, Eriko; Arisawa, Mikio

doi:10.1128/jcm.37.6.1732-1738.1999

Cited by 109 publications

(54 citation statements)

References 24 publications

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“…In 1999-2003, the gastrointestinal and respiratory tracts, including the peritoneum, were most affected by Candida. These results correspond with those of Groll et al 9 and Yamazaki et al 11 The primary diseases were non-haematological neoplasia and pneumonia in contrast to other reports. 1,[5][6][7][8][9] Liver and spleen were rarely (six or five times) infected in our material with only few organ transplantations.…”

Section: Discussionsupporting

confidence: 92%

Candidosis and aspergillosis as autopsy findings from 1994 to 2003

Schwesinger

Junghans

Schröder

et al. 2005

Mycoses

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We analysed the autopsy records of the Greifswald University Institute of Pathology (located in Eastern Germany) in respect of findings of candidosis and aspergillosis from 1994 to 2003. We also present eight immature aborted fetuses and premature infants with a mycosis. In a total of 2027 autopsies we found 164 cases of invasive candidosis and aspergillosis (8.1%) including a combination of both on four occasions. Other authors cited between 0.7 and 7.3%. In these 10 years in our material mycoses and in particular candidosis increased in spite of slightly decreased numbers of autopsies. The differences comparing the 5-years periods (1994-98 and 1999-2003) are highly significant for both mycoses and candidosis. They are not significant for aspergillosis. A similar relationship was observed in the distribution of mycotic organs and causative origin for candidosis alone. In the last 5 years the gastrointestinal and respiratory tracts, including the peritoneum, were more frequently infected by Candida. Non-haematological neoplasia and pneumonia as basic diseases more often appeared in cases of candidosis. All eight immature aborted fetuses and premature infants suffered from candidosis. The survey confirms the importance of autopsy as a tool for education and quality control in medical diagnostic and therapeutic activity in the field of mycoses, too.

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Section: Discussionsupporting

confidence: 92%

Candidosis and aspergillosis as autopsy findings from 1994 to 2003

Schwesinger

Junghans

Schröder

et al. 2005

Mycoses

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“…In a large epidemiological study of Yamazaki et al [50] the retrospective autopsy data from 1969 to 1994 were compiled by the Japanese Society of Pathology from data gathered from university hospitals, public hospitals, and large private hospitals all over Japan. There were 594 263 autopsies and 17 775 found mycoses (2.99%).…”

Section: Epidemic Studies Of Fungal Infections In Autopsiesmentioning

confidence: 99%

Is there a need for autopsies in the management of fungal disease?

Knoke

Bernhardt

Schwesinger

2008

Mycoses

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The autopsy rates in Germany became low like in other European, American and Asian countries. Main reasons for this development are the lack of acceptance of autopsy in the society as well as in the medical profession, the introduction of a requirement for consent, unclear legal position, the public health system, pressure of costs and a change in the field of activity in pathology with much more diagnostics of surgical and biopsy material. The autopsy is missing with respect to the reliability of causes of death and morbidity statistics and other epidemiological studies. Published data indicate that up to 20-30% of patients who die in hospitals have important diseases/lesions that remain undetected before death but that are found at autopsy. For infectious diseases, the data are similar. Therefore, a higher incidence of invasive fungal infections was found. Some rare fungal disorders are diagnosed by autopsy. Only exact death statistics makes specific health care possible and is cost saving in a public health system in the long term. Autopsy remains an important tool for quality control in medical diagnostic and therapeutic activity. It is also essential for fundamental medical education and further training.

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“…Since the first description of invasive aspergillosis in the 1950s, the frequency and severity of this opportunistic infection have increased continually. [93][94][95][96][97] It has emerged as the leading cause of death due to fungal infection, and its prevalence, even in unselected autopsies, was reported to be as high as 4-5%. [93][94][95] Increased intensity of chemotherapy in patients with hematologic malignancies, increases in allogeneic bone marrow and solid organ recipients, the AIDS pandemic, and expansion of the population treated with steroids for various conditions account for that relentless rise.…”

Section: Aspergillosismentioning

confidence: 99%