Epidemiology of visceral mycoses in autopsy cases in Japan: the data from 1989 to 2009 in the Annual of Pathological Autopsy Cases in Japan

Suzuki, Yuhko; Kume, Hikaru; Togano, Tomiteru; Kanoh, Yuhsaku; Ohto, Hitoshi

doi:10.3109/13693786.2012.755574

Cited by 38 publications

(31 citation statements)

References 28 publications

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“…Therefore, it is very important to encourage students and professors of medical schools to make a postmortem examination a remarkable practice. 37,42 …”

Section: Discussionmentioning

confidence: 99%

Cryptococcosis in Acquired Immunodeficiency Syndrome Patients Clinically Confirmed and/or Diagnosed at Necropsy in a Teaching Hospital in Brazil

Torres

Etchebehere

Adad

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Cryptococcosis occurs in acquired immunodeficiency syndrome (AIDS) patients with poor compliance to antiretroviral therapy or unaware of their human immunodeficiency virus status who present severe immunosuppression at admission. Consequently, high mortality rates are observed due to disseminated fungal infection. This report presents clinical and postmortem data of AIDS patients with cryptococcosis in a teaching hospital in Brazil. Retrospectively, medical and necropsy records of AIDS patients with cryptococcosis clinically confirmed and/or postmortem verified were reviewed. Clinical data were compared with those of patients presenting a good outcome to evaluate disseminated fungal infection and the agreement between clinical and postmortem diagnosis. At admission, most of the 45 patients with cryptococcal meningitis who died, presented more altered consciousness (P = 0.0047), intracranial increased pressure (P = 0.047), and severe malnutrition (P = 0.0006) than the survivors. Of 29 (64.4%) patients with cryptococcal meningitis, 23 died before week 2 on antifungal therapy, and the other six during the next 3 months. The remaining 16 (35.6%) cases had other diagnoses and died soon after. At necropsy, 31 (68.9%) presented disseminated infection involving two or more organs, whereas 14 (31.1%) cases had meningeal or pulmonary localized infection. The agreement of 64.4% between clinical and postmortem diagnosis was similar to some studies. However, other reports have shown figures ranging from 34% to 95%. Currently, a progressive worldwide decrease of autopsies is worrying because the role of postmortem examination is pivotal to verify or identify the death causes, which contributes to improve the quality of clinical diagnosis and medical training.

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“…Therefore, it is very important to encourage students and professors of medical schools to make a postmortem examination a remarkable practice. 37,42 …”

Section: Discussionmentioning

confidence: 99%

Cryptococcosis in Acquired Immunodeficiency Syndrome Patients Clinically Confirmed and/or Diagnosed at Necropsy in a Teaching Hospital in Brazil

Torres

Etchebehere

Adad

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…Although the prevalence of fungal infections in childhood cancer patients is 4%, mortality rate is 40-80%. The success of treatment of fungal infections has increased in recent years with the use of new antifungal therapies [1].…”

Section: Voriconazole Induced Bradycardiamentioning

confidence: 99%

Voriconazole Induced Bradycardia

Uludağ

Özdemir

Tüysüz

et al. 2013

Pediatric Hematology and Oncology

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Voriconazole is a triazole antifungal drug that is used to treat invasive fungal infections, especially aspergillus. Here, we report two children who had severe bradycardia associated with voriconazole at a dose of 12 mg/kg per day. Bradycardia resolved in 24 hours in both after decreasing the dose to 10 mg/kg per day. Heart rates were in normal limits on follow-up. Bradycardia may be a side effect of voriconazole treatment in children under immunosuppressive treatment. Heart rate should be monitored in patients receiving voriconazole and other triazole treatments.

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“…From 2008 to 2013, 11 single-center, multi-center and nationwide autopsy reports on IFD have been published worldwide in PubMed [1–6,15–19]. These reports include data on 9187 IFDs observed in 193,095 autopsies.…”

Section: Autopsy Reports On Invasive Fungal Diseasesmentioning

confidence: 99%

“…Six reports conducted in the general population included 8076 IFDs from 188,228 autopsies, with a prevalence of 4.2 to 5 IFDs per 100 autopsies (Table 4) [5,15–19]. …”

Section: Autopsy Reports On Invasive Fungal Diseasesmentioning

confidence: 99%

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Epidemiology of invasive fungal diseases on the basis of autopsy reports

Dignani¹

2014

F1000Prime Rep

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Invasive fungal diseases (IFDs) are a major cause of morbidity and mortality among immunocompromised patients and cost to health services. They are difficult to prevent, diagnose, and treat. This difficulty in diagnosis leads us to treat them empirically by using several tools, including epidemiological data, non-culture methods and images. Most of the available epidemiological information may not be accurate because we are dealing with a disease that only has an estimated 50% chance of being diagnosed before death. Therefore, autopsy reports become a valuable tool, not only to define the real epidemiology, but also to address the trend in pre-mortem diagnosis, which is the best marker available to prove the efficiency of the research in IFD.This article reviews and analyzes the data on IFD obtained from 11 single-center, multi-center and nationwide autopsy reports published between 2008 and 2013, and also discusses the issues we need to address in order to improve the quality of the epidemiological data on invasive fungal disease obtained from autopsy reports.

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Epidemiology of visceral mycoses in autopsy cases in Japan: the data from 1989 to 2009 in the Annual of Pathological Autopsy Cases in Japan

Cited by 38 publications

References 28 publications

Cryptococcosis in Acquired Immunodeficiency Syndrome Patients Clinically Confirmed and/or Diagnosed at Necropsy in a Teaching Hospital in Brazil

Cryptococcosis in Acquired Immunodeficiency Syndrome Patients Clinically Confirmed and/or Diagnosed at Necropsy in a Teaching Hospital in Brazil

Voriconazole Induced Bradycardia

Epidemiology of invasive fungal diseases on the basis of autopsy reports

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