Epidemiology of vulvar and vaginal cancer in Germany

Dittmer, C.; Katalinic, Alexander; Mundhenke, Christoph; Thill, Marc; Fischer, Dorothea

doi:10.1007/s00404-011-1850-9

Cited by 56 publications

(48 citation statements)

References 28 publications

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“…We also found that the incidence increased with age, as has been suggested by other authors [6,13,14,15,16]. However, our patients ranged in age from 15 to 98 years.…”

Section: Discussionsupporting

confidence: 70%

Characterization of Sociodemographic and Clinicopathological Features in Brazilian Patients with Vulvar Squamous Cell Carcinoma

Maia

Cestari

Lavorato-Rocha

et al. 2012

Gynecol Obstet Invest

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Aim: To investigate sociodemographic and clinical-epidemiological profiles of patients with vulvar carcinoma in São Paulo, the largest city of Brazil, to establish a more consistent profile of these features once the incidence of vulvar carcinoma has risen considerably. Data regarding the epidemiological aspects of this tumor are scarce. Methods: A retrospective study was performed using 300 medical records from patients diagnosed with squamous cell carcinoma of the vulva and surgically treated at A.C. Camargo Hospital in São Paulo, Brazil, from 1978 to 2009. Results: The median age of onset was 70 years, ranging from 15 to 98 years, and most women were white (88.51%). Most patients (83.54%) had little or no schooling and had the lowest survival curve. Many patients were diagnosed in the early stages of the disease (57.09% FIGO IB), 59% had complications due to surgery and 43.71% had disease recurrence, of which about 70% died. Conclusions: Our study adds 300 Brazilian cases of vulvar carcinoma to the world literature. Given the high rate of disease recurrence and mortality in Brazil, we conclude that regular gynecologic evaluation and educational policies should be reinforced in order to raise awareness for vulvar cancer.

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“…We also found that the incidence increased with age, as has been suggested by other authors [6,13,14,15,16]. However, our patients ranged in age from 15 to 98 years.…”

Section: Discussionsupporting

confidence: 70%

Characterization of Sociodemographic and Clinicopathological Features in Brazilian Patients with Vulvar Squamous Cell Carcinoma

Maia

Cestari

Lavorato-Rocha

et al. 2012

Gynecol Obstet Invest

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“…The highest incidence rates are reported in Latin America, whereas the lowest incidence rates were confirmed in Japan and China. Advanced age, cigarette smoking, low socioeconomic status, chronic inflammation, lichen sclerosus and immunosuppression are proven factors enhancing the development of type I vulvar cancer, which may occur without pervious VIN lesions [5,6]. Type II vulvar cancer primarily affects younger women (<50 years of age) as a result of the progression and invasion of VIN lesions.…”

Section: Introductionmentioning

confidence: 99%

“…Vaginal cancer can develop at any age, but its highest incidence is observed in women over 65 years of age [6]. In younger females, glandular vaginal cancer can be the result of in utero exposure to diethylstilbestrol.…”

Section: Introductionmentioning

confidence: 99%

Primary Vulvo-Vaginal Cancers: Trends in Incidence and Mortality in Poland (1999-2012)

Banaś

Pitynski

Jach

et al. 2015

Gynecol Obstet Invest

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Background: The aim of this study was to determine the incidence, mortality rates and trends of vulvar and vaginal cancers in Poland. Methods: Data were retrieved from the Polish National Cancer Registry. Age-standardised rates (ASRs) of cancer incidence and mortality were calculated by direct standardisation, and joinpoint regression was performed to describe the trends using the average annual percent change (AAPC). Results: From 1999 to 2012, the number of diagnosed cases of vulvar cancer was 5,958, and the ASRs of incidence varied from 0.99 to 1.18, with a significant trend towards a decrease (AAPC -0.78; p < 0.05). The ASR of mortality varied from 0.39 to 0.62, with a slight but insignificant increase in trend (AAPC 0.72; p > 0.05). The ASR of vaginal cancer incidence varied from 0.21 to 0.31, while the ASR of mortality ranged from 0.09 to 0.22. This study also proved a significantly falling trend in vaginal cancer mortality (AAPC -4.69; p < 0.05) and a decreasing trend in vaginal cancer incidence (AAPC -1.67; p > 0.05). Conclusion: The rarity of vulvar and vaginal cancers as well as the decline in their incidence rates should not discourage further research on the epidemiology and treatment of these conditions.

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“…Although high risk HPV infection is a well-established cause of cervical cancer, but there is now growing evidence of HPV being a relevant factor in vulva and Vaginal cancers. HPV infection is associated with both of benign and malignant lesions and almost detected in the younger women rather than elder women (zur Hausen, 2002;De Vuyst et al, 2009;Ramet et al, 2010;Dittmer et al, 2011) In this study, HPV DNA detection was performed on section of paraffin-embedded biopsy. The frequency of HPV positive was detected to be 47.06% and 60% in vulva and Vaginal cancers, respectively.…”

Section: Discussionmentioning

confidence: 99%

Detection and Type-Distribution of Human Papillomavirus in Vulva and Vaginal Abnormal Cytology Lesions and Cancer Tissues from Thai Women

Ngamkham

Boonmark²,

Phansri³

2016

Asian Pacific Journal of Cancer Prevention

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Epidemiology of vulvar and vaginal cancer in Germany

Cited by 56 publications

References 28 publications

Characterization of Sociodemographic and Clinicopathological Features in Brazilian Patients with Vulvar Squamous Cell Carcinoma

Characterization of Sociodemographic and Clinicopathological Features in Brazilian Patients with Vulvar Squamous Cell Carcinoma

Primary Vulvo-Vaginal Cancers: Trends in Incidence and Mortality in Poland (1999-2012)

Detection and Type-Distribution of Human Papillomavirus in Vulva and Vaginal Abnormal Cytology Lesions and Cancer Tissues from Thai Women

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