Epidemiology of Wegener Granulomatosis Since the Introduction of ANCA Testing in Olmsted County, MN, 1990–1999

Ng, Bernard T; Specks, Ulrich; Offord, Kenneth P.; Matteson, Eric L.

doi:10.1097/01.rhu.0000089786.10614.51

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…Interestingly, we observed a higher incidence of GPA than has been previously reported in the US and in non‐US published data sets . In particular, compared to previously reported data, the annual US‐adjusted annual incidence of GPA increased from 0.83 cases per 100,000 in the early 1990s to 1.3 cases per 100,000 in the last 2 decades.…”

Section: Discussioncontrasting

confidence: 47%

“…The only population‐based analysis of AAV frequency conducted in the US showed that the annual incidence of GPA (adjusted to the US population) was 0.83 cases per 100,000 population (95% confidence interval [95% CI] 0.25–1.42), roughly similar to estimates from northern Europe . Previous epidemiologic studies from the US have demonstrated discrepant prevalence rates for GPA, between 3.2 and 9.1 per 100,000 population .…”

mentioning

confidence: 54%

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The Epidemiology of Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis in Olmsted County, Minnesota

Berti

Cornec

Crowson

et al. 2017

Arthritis & Rheumatology

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166

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Objective To estimate the incidence, prevalence and mortality of ANCA-associated vasculitis (AAV) and its subsets, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic GPA (EGPA), in a U.S. based adult population. Methods All medical records of patients with a diagnosis or suspicion of AAV in Olmsted County, Minnesota from January 1, 1996 to December 31, 2015 were reviewed. Incidence rates were age- and sex-adjusted to the 2010 US white population. Age- and sex-adjusted prevalence was calculated on January 1, 2015. Survival rates were compared with expected rates in the Minnesota population. Results Of 58 incident cases of AAV, 23 (40%) were GPA, 28 (48%) MPA, and 7 (12%) EGPA. Overall, 28 (48%) were women, 57 (98%) were Caucasian, with a mean±SD age at diagnosis of 61.1±16.5 years. Thirty-four patients (61%) were MPO-ANCA and 17 (30%) were PR3-ANCA positive; 5 (9%) were ANCA-negative. The annual incidence of AAV was 3.3/100,000 population (95%CI: 2.4–4.1). GPA, MPA and EGPA incidence was 1.3 (95%CI: 0.8–1.8), 1.6 (95%CI: 1.0–2.2), and 0.4 (95%CI: 0.1–0.6), respectively. Overall prevalence of AAV was 42.1/100,000 (95%CI: 29.6–54.6). Mortality for AAV overall, and EGPA, MPA and MPO-ANCA was increased (p<0.05); mortality of GPA, PR3-ANCA and ANCA-negative patients did not differ from general population. Conclusion The annual incidence of AAV in Olmsted County is 3.3/100,000, with prevalence of 42.1/100,000, substantially higher than reported in other areas worldwide. The incidence of GPA and MPA is similar. Mortality of MPA and EGPA, but not GPA, is higher than the general population; MPO-ANCA is a marker of poor survival.

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Section: Discussioncontrasting

confidence: 47%

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confidence: 54%

The Epidemiology of Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis in Olmsted County, Minnesota

Berti

Cornec

Crowson

et al. 2017

Arthritis & Rheumatology

Self Cite

166

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“…The incidence of GPA also seems to vary by location, with higher incidence rates reported in most European countries, Australia, and the United States (6-14/million) compared to Japan (2/million) 4,5,8,9,28,31,32 . The incidence rates in some European countries (Spain and Lithuania) were low (2-5/million) 10,27,29,30 , as was the incidence rate in our population (4.1/million).…”

Section: Discussionmentioning

confidence: 99%

The Incidence of Primary Systemic Vasculitis in Jerusalem: A 20-year Hospital-based Retrospective Study

Nesher

Ben‐Chetrit²,

Mazal

et al. 2016

J Rheumatol

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“…Estimates of the overall annual incidence range between 0.5 and 20 cases per 1 million persons, with a prevalence of 20–160 cases per 1 million persons . A small population‐based study in Olmsted County, Minnesota showed an annual incidence of 8 GPA cases per 1 million persons, but was limited by a small sample size (n = 8) . A larger US study using a national hospital discharge database demonstrated a prevalence of 26 GPA cases per 1 million persons based on 10,771 hospitalizations .…”

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confidence: 99%

Epidemiology and Outcomes of Granulomatosis With Polyangiitis in Pediatric and Working‐Age Adult Populations In the United States

Panupattanapong

Stwalley

White

et al. 2018

Arthritis & Rheumatology

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Epidemiology of Wegener Granulomatosis Since the Introduction of ANCA Testing in Olmsted County, MN, 1990–1999

Cited by 3 publications

References 6 publications

The Epidemiology of Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis in Olmsted County, Minnesota

The Epidemiology of Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis in Olmsted County, Minnesota

The Incidence of Primary Systemic Vasculitis in Jerusalem: A 20-year Hospital-based Retrospective Study

Epidemiology and Outcomes of Granulomatosis With Polyangiitis in Pediatric and Working‐Age Adult Populations In the United States

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