Epidemiology of women diagnosed with breast cancer in Jordan

Mousa, Rimal; Melhem, Jamal Masad; Hammad, Eman A.

doi:10.15537/smj.2021.42.7.20210112

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…However, a study conducted between 2004 and 2008 in Iraq reported that 54.1% of patients were younger than 50 years old, indicating a shift in the age distribution of breast cancer cases in Iraq over time [20] . This trend is also observed in Jordan, where 53.7% of breast cancer patients were over the age of 50 [21] . Moreover, a multicentric, crosssectional study conducted at three hospitals in KSA from February 2019 to February 2020 reported that the risk of breast cancer increased with age in Saudi Arabia [22] .…”

Section: Discussionsupporting

confidence: 63%

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Demographic and Clinical Characteristics of Females with Breast Cancer in Iraq with Respect to Age: A Single-Center Study

Alrubai,

Zaki,

Mohsun

et al. 2023

Forum of Clinical Oncology

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Background Breast cancer is a growing concern in Iraq, posing significant health challenges for Iraqi women. The objective of this study was to describe the demographic and clinical characteristics associated with breast cancer among Iraqi women, with a specific focus on age-related differences. Materials and Methods Medical records of 500 female patients diagnosed with breast cancer between 2017 and 2022 were retrospectively analyzed. Demographic information, clinical history, presentation details, treatment modalities, and outcomes were collected and analyzed. Results Among the studied cohort, 62.4% of breast cancer cases were diagnosed in women aged 50 and older. Marital status correlated significantly with age, with 89.9% of those diagnosed before 50 being married compared to 74.7% of those diagnosed after 50. Notably, 48% of patients diagnosed before 50 had breastfeeding duration of 1–3 months, contrasting with 28.5% of those diagnosed after 50. Diabetes mellitus, hypertension, hypercholesterolemia, heart disease, and vitamin D deficiency were significantly more prevalent among patients diagnosed after 50. Clinical presentation revealed 67.8% with tumor stage II. Metastasis to lymph nodes occurred in approximately 50% of patients. Among patients who were diagnosed after 50 years of age, 34% had metastasis, compared to 22.9% of those diagnosed before the age of 50. Mortality rates were higher in patients diagnosed after 50 (23%) compared to those under 50 (12.8%). Conclusion The findings emphasize the need for targeted public health campaigns, early detection initiatives, and treatment optimization to improve patient outcomes and mitigate the burden of breast cancer.

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Section: Discussionsupporting

confidence: 63%

“…For example, in a study by Mutar et al, invasive ductal carcinoma was the most common (81.4%), followed by invasive lobular carcinoma (6.9%) [19] . Similarly, in a study conducted in Jordan, 86.9% of patients had ductal carcinoma [21] . Another study conducted in Mexico found that 79% of patients had ductal histology [39] .…”

Section: Discussionmentioning

confidence: 79%

Demographic and Clinical Characteristics of Females with Breast Cancer in Iraq with Respect to Age: A Single-Center Study

Alrubai,

Zaki,

Mohsun

et al. 2023

Forum of Clinical Oncology

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“…Health consumers look for care plans tailored to meet their cultural expectations [5] The Arab league consists of 22 countries with a massive socioeconomic range, yet linguistic, cultural, religious, and demographic cohesion exists. The majority of the Arab population consists of youth and children [6,7]. Beliefs and practices of Arabs are highly inspired by the principles of Islam [8].…”

Section: Introductionmentioning

confidence: 99%

“…To offer culturally competent care, healthcare providers must understand the culture and religion of the groups they are handling. Delivering culturally competent care is almost certainly not an easy task, but is still a very worthwhile one for both healthcare providers and women [6]. Unborn and newborn rights are defined in numerous ways, including through a wide spectrum of civil, cultural, economic, social, and political rights [15, 16].…”

Section: Introductionmentioning

confidence: 99%

The Rights of Unborn and Newborn Babies in Jordanian Arab Culture: Implications for Practice

Bawadi¹,

Al-Hamdan²,

Farhat³

et al. 2022

TONURSJ

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Background: Traditional patterns relating to how to handle the provision of culturally competent care for refugees are often challenging. Addressing the unique religious and cultural beliefs and norms of refugee parents during the childbirth process will alleviate their anxiety and feelings of alienation with respect to healthcare systems. Objectives: This paper aims to understand the meaning of Jordanian women’s beliefs and practices related to their foetuses and newborns and to facilitate the recognition by Western healthcare providers of these practices among immigrants and refugees. Methods: An interpretive phenomenological study was used to conduct an individual in-depth semi-structured interview with nine women. Results: Eight superordinate themes were identified: couple in legitimate relationship before conception, rejection of abortion, accepting the gender of the baby, guaranteeing that ‘Allah’ is the first word heard, rubbing the newborn’s palate with a date, choosing a meaningful name, ensuring circumcision for boys and showing gratitude to Allah. Conclusion: The attitudes of Jordanian women towards newborns’ rights and care are greatly influenced by their cultural and religious backgrounds. Capturing these attitudes and needs can inform the development of health education strategies and information resources. To enhance Muslim women’s engagement in maternal newborn health services, maternity staff should endeavour to create a trusting relationship with the childbearing women, which values their social, cultural and spiritual needs.

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Combination of resveratrol and piperine to target doxorubicin resistance in breast cancer: An in vitro and in vivo study

AlHur,

Barakova,

Talib

2024

PHAR

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One of the biggest causes of death worldwide is cancer, which poses a serious threat to healthcare systems all over the world. Triple-negative breast cancer (TNBC), in particular, presents substantial clinical challenges because it does not express Human Epidermal Growth Factor Receptor 2 (HER2) or hormone receptors. Despite concerns about early recurrence and drug resistance, chemotherapy, particularly anthracyclines like Doxorubicin (DOX), remains the mainstay of treatment for TNBC patients. This research investigates the possibility of using natural products, especially piperine (PIP) and resveratrol (RES), to overcome DOX resistance. PIP and RES have shown anticancer effects via various pathways, such as inducing apoptosis and controlling the cell cycle. In this research, in vitro experiments showed that RES and PIP inhibit cell growth in a dose-dependent manner using triple-negative parent mouse mammary breast cancer cells and DOX resistance cells (EMT-6/P and EMT-6/DOX). RES in EMT-6/P cells showed an IC50 value of 146.511 ± 5.35 μM, and in EMT-6/DOX cells, it was 88.635 ± 29.507 μM. In the same way, PIP was found to have IC50 values of 148.819 ± 14.317 and 9.375 μM in the triplicate trials in EMT-6/P and EMT-6/DOX, respectively. Furthermore, on both cell lines, the combination demonstrated very strong synergistic effects; noticeably lower doses were needed for the combined treatment to reduce cell viability by 50%. The IC50 values for the combination treatments of RES and PIP were found to be < 2.289 µM and < 2.325 µM in EMT-6/P cells, respectively, with values < 0.348 µM and 0.243 ± 0.142 µM in EMT-6/DOX cells. The in vivo experiment conducted on Balb/C females indicated that mice bearing EMT-6/Dox cells and treated with the combination of RES and PIP had the highest cure percentage; however, this treatment showed mild toxicity. The study clarifies the potential synergistic activity between PIP and RES in combating DOX-resistant TNBC cells. These findings highlight the significance of investigating natural products as supplemental therapies in cancer treatment and provide insights into new treatment approaches. While the combination shows promise as a therapeutic option for treating breast cancer, especially in cases of DOX resistance, further investigation is needed.

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Epidemiology of women diagnosed with breast cancer in Jordan

Cited by 4 publications

References 24 publications

Demographic and Clinical Characteristics of Females with Breast Cancer in Iraq with Respect to Age: A Single-Center Study

Demographic and Clinical Characteristics of Females with Breast Cancer in Iraq with Respect to Age: A Single-Center Study

The Rights of Unborn and Newborn Babies in Jordanian Arab Culture: Implications for Practice

Combination of resveratrol and piperine to target doxorubicin resistance in breast cancer: An in vitro and in vivo study

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