Epidemiology, Risk Factors, and Consequences of Obstructive Sleep Apnea and Short Sleep Duration

Lawati, Nabil M Al; Patel, Sanjay R.; Ayas, Najib

doi:10.1016/j.pcad.2008.08.001

Cited by 332 publications

(219 citation statements)

References 88 publications

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“…Pathologic disruption of sleep and variations in sleep habits are associated with a number of adverse health and safety outcomes. Obstructive sleep apnea is a very common disease, whose population prevalence is comparable to that of other important chronic diseases such as asthma, chronic obstructive pulmonary disease, type 2 diabetes, and coronary artery disease [41,42]. …”

Section: Discussionmentioning

confidence: 99%

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

et al. 2011

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Aging and physical inactivity are two factors that favors the development of cardiovascular disease, metabolic syndrome, obesity, diabetes, and sleep dysfunction. In contrast, the adoption a habitual of moderate exercise may present a non-pharmacological treatment alternative for sleep and metabolic disorders. We aimed to assess the effects of moderate exercise training on sleep quality and on the metabolic profile of elderly people with a sedentary lifestyle. Fourteen male sedentary, healthy, elderly volunteers performed moderate training for 60 minutes/day, 3 days/week for 24 wk at a work rate equivalent to the ventilatory aerobic threshold. The environment was kept at a temperature of 23 ± 2°C, with an air humidity 60 ± 5%. Blood and polysomnographs analysis were collected 3 times: at baseline (1 week before training began), 3 and 6 months (after 3 and 6 months of training). Training promoted increasing aerobic capacity (relative VO2, time and velocity to VO2max; p < 0.05), and reduced serum NEFA, and insulin concentrations as well as improved HOMA index (p < 0.05), and increased adiponectin levels (p < 0.05), after 3 months of training when compared with baseline data. The sleep parameters, awake time and REM sleep latency were decreased after 6 months exercise training (p < 0.05) in relation baseline values. Our results demonstrate that the moderate exercise training protocol improves the sleep profile in older people, but the metabolism adaptation does not persist. Suggesting that this population requires training strategy modifications as to ensure consistent alterations regarding metabolism.

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Section: Discussionmentioning

confidence: 99%

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

et al. 2011

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“…8 Other serious health consequences of OSA in the able-bodied population include increased risk of cardiovascular disease, diabetes and premature death. 9 This observational study describes the subjective sleep disturbances and quality of life of a chronic tetraplegic population and, where possible, compares the results with the best available published ablebodied (normative) data. The study also explores the relationships between quality of life, subjective sleep disturbances and injury severity in chronic tetraplegia.…”

Section: Introductionmentioning

confidence: 99%

Subjective sleep disturbances and quality of life in chronic tetraplegia

et al. 2015

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Study design: This is a cross-sectional survey. Objectives: The objective of this study was to evaluate the subjective sleep disturbances and quality of life in chronic tetraplegia. Setting: This study was conducted in a community sample from Victoria, Australia. Methods: People with tetraplegia were mailed a survey battery including the following: demographic questions; Karolinska Sleepiness Scale (KSS); Basic Nordic Sleepiness Questionnaire; Functional Outcomes of Sleep Questionnaire (FOSQ); Multivariate Apnoea Prediction Index and Assessment of Quality of Life (AQoL) Questionnaire. Scores were compared with the best available normative data. Results: A total of 163 of 424 (38%) surveys were returned (77% male; 39% sensory and motor complete; mean age±s.d. = 46±14 years; mean years since injury = 11±8 years). The AQoL health utility score (0.31±0.29) was significantly lower than published population norms. FOSQ total (17.55±2.57) and KSS (3.93±2.27) scores were no different from the best available population data. People with tetraplegia reported worse sleep habits, symptoms and quality than a normal population, as indicated on 17 of 21 questions on the Basic Nordic Sleep Questionnaire. Multivariate analysis found that greater injury severity (coefficient (95% CI) = 0.14 (0.10, 0.18)), increasing age (−0.004 (−0.008, − 0.001)) and worse sleep symptoms (−0.005 (−0.009, − 0.0003)) were all significantly associated with reduced quality of life. Conclusion: People with chronic tetraplegia experience more subjective sleep problems and worse quality of life than their able-bodied counterparts. Quality of life is related to injury severity, age and sleep symptoms. Treating the sleep disorders experienced by people living with tetraplegia has the potential to improve their health and well-being.

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“…4 Sleep duration has been related to many important adverse effects on health. [5][6][7][8][9][10] Short sleep duration has been associated with diabetes, hypertension, 10 cardiovascular disease (CVD) 8 9 and increased mortality. [5][6][7] A recent meta-analysis of cross-sectional studies on sleep duration and the metabolic syndrome showed that sleep duration under 5 hours significantly increased the risk for metabolic syndrome independently of other known risk factors.…”

Section: Introductionmentioning

confidence: 99%

Respiratory symptoms are more common among short sleepers independent of obesity

et al. 2017

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Introduction Sleep length has been associated with obesity and various adverse health outcomes. The possible association of sleep length and respiratory symptoms has not been previously described. The aim of this study was to investigate the association between sleep length and respiratory symptoms and whether such an association existed independent of obesity. Methods This is a multicentre, cross-sectional, population-based study performed in 23 centres in 10 different countries. Participants (n=5079, 52.3% males) were adults in the third follow-up of the European Community Respiratory Health Survey III. The mean±SD age was 54.2±7.1 (age range 39-67 years). Information was collected on general and respiratory health and sleep characteristics. results The mean reported nighttime sleep duration was 6.9±1.0 hours. Short sleepers (<6 hours per night) were n=387 (7.6%) and long sleepers (≥9 hours per night) were n=271 (4.3%). Short sleepers were significantly more likely to report all respiratory symptoms (wheezing, waking up with chest tightness, shortness of breath, coughing, phlegm and bronchitis) except asthma after adjusting for age, gender, body mass index (BMI), centre, marital status, exercise and smoking. Excluding BMI from the model covariates did not affect the results. Short sleep was related to 11 out of 16 respiratory and nasal symptoms among subjects with BMI ≥30 and 9 out of 16 symptoms among subjects with BMI <30. Much fewer symptoms were related to long sleep, both for subjects with BMI <30 and ≥30. conclusions Our results show that short sleep duration is associated with many common respiratory symptoms, and this relationship is independent of obesity.

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Epidemiology, Risk Factors, and Consequences of Obstructive Sleep Apnea and Short Sleep Duration

Cited by 332 publications

References 88 publications

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner

Subjective sleep disturbances and quality of life in chronic tetraplegia

Respiratory symptoms are more common among short sleepers independent of obesity

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