Epidemiology, risk factors and outcomes of multidrug-resistant bacteria colonization in a Moroccan medical intensive care unit

Oussayeh, Imane; Moussaid, Fahd; Traoré, Aminata Oumou; Touiti, Akram; Elkhayari, Mina; Soraa, Nabila; Hachimi, Abdelhamid

doi:10.11604/pamj-cm.2021.5.33.20952

Cited by 2 publications

(3 citation statements)

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“…However, in many other countries, such as Morocco, where this study was carried out, too many factors combine to lead to poor controls on the progression of AMR (e.g., poor sanitary conditions, poverty, lack of housing) ( 22 ). Moreover, a study conducted in Morocco showed that MDRB infection is a significant health problem and is responsible for higher morbidity and mortality, longer duration of mechanical ventilation, and prolonged ICU stay ( 17 ). In such countries, we might see even more propagation of resistant bacteria if economies and governance deteriorate further ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…More than 2.8 million MDRB infections occur annually in the USA, causing at least 35000 deaths and $20 billion in healthcare expenditures ( 16 ). A Moroccan study showed that MDRB infection is a significant health problem and is responsible for higher morbidity and mortality, longer duration of mechanical ventilation, and more extended intensive care unit (ICU) stay ( 17 ). In acute care environments, the long-term propagation of AMR due to increased patient exposure to inappropriately used antimicrobials remains a possible consequence of the COVID-19 pandemic and an issue of concern.…”

Section: Introductionmentioning

confidence: 99%

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Microbiological profile of multidrug resistant bacteria before and during COVID-19 in CHU Mohammed VI

Bennani,

Guennouni,

Ouarradi

et al. 2023

IJM

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Background and Objectives: A new type of corona virus has caused Corona virus disease-19 and, subsequently, a global pandemic. All individuals are prone to the disease, so drastic measures were taken to prevent its spread. This study aimed to evaluate the impact of COVID-19 on the progression of the antimicrobial resistance rate by comparing two periods: before and during COVID-19. Materials and Methods: We used a cross-sectional design to investigate the Antimicrobial Resistance (AMR) rate before (03/2019 to 03/2020) and during COVID-19 (03/2020 to 03/2021) in a University Hospital in Marrakech. The data were analyzed using SPSS Version 25.0. Results: Among the 7106 specimens, there was a significant increase in the multidrug-resistant bacterial from 27.38% to 35.87% during COVID-19 (p<0.001), particularly in blood culture, cerebrospinal fluid, catheter, and pus. However, there was a non-significant change in puncture fluid, expectoration, protected distal sampling, joint fluid, stool culture, and genital sampling. A decrease in Multidrug-resistant bacteria (MDRB) was observed only in cytobacteriological urine tests (p<0.05). According to species, there was an increase in extended-spectrum beta-lactamase-producing Enterobacteriaceae, carbapen- em-resistant Enterobacteriaceae, and methicillin-resistant Staphylococcus aureus. Conclusion: In our study, it is particularly noticeable that the MDRB has increased. These results highlight the importance that the pandemic has not been able to slow the progression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbiological profile of multidrug resistant bacteria before and during COVID-19 in CHU Mohammed VI

Bennani,

Guennouni,

Ouarradi

et al. 2023

IJM

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“…Such as previous hospitalization, previous antibiotic treatment, length of hospital stays, and co-morbidities like surgery, liver cirrhosis, diabetics, and renal diseases [78][79][80]. In healthcare facilities, intestinal carriage of ESBL-PE is one of the main reservoirs of multidrug-resistant bacteria which have been associated with high risk for developing infections [81,82]. In our meta-analysis, six studies were eligible to assess the association of…”

Section: Plos Onementioning

confidence: 99%

Colonization with extended spectrum beta-lactamase and carbapenemases producing Enterobacteriaceae among hospitalized patients at the global level: A systematic review and meta-analysis

Abera,

Alemu,

Mihret

et al. 2023

PLoS ONE

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Background Gut commensal bacteria can mediate resistance against pathogenic bacteria. However, exposure to antibiotics and hospitalization may facilitate the emergence of multidrug resistant bacteria. We aimed to conduct a systematic review and meta-analysis to provide comprehensive evidence about colonization rate of extended spectrum beta-lactamase and carbapenemases producing Enterobacteriaceae. Method We used PubMed, Google Scholar and Web of Science data bases to search studies from January 1, 2016 to August10, 2022 about colonization rate of extended spectrum beta-lactamase and carbapenemase producing Enterobacteriaceae. Data were extracted from eligible studies and analyzed using Stata version 16 software. The quality of included studies was assessed using the Joanna Briggs Institute Critical Appraisal tools, and publication bias was assessed using funnel plot and eggers test. Results We identified 342 studies from the comprehensive data search and data were extracted from 20 studies. The pooled estimate of extended spectrum beta-lactamase and carbapenemase producing Enterobacteriaceae were 45.6%(95%CI: 34.11-57-10) and 16.19% (95% CI: 5.46–26.91) respectively. The predominant extended spectrum beta-lactamase producers were E. coli,32.99% (95% CI: 23.28–42.69) and K. pneumoniae, 11.43% (95% CI:7.98–14.89). Prolonged hospitalization was linked to carbapenemase producing Enterobacteriaceae colonization with the odds of 14.77 (95% CI: -1.35–30.90) at admission and 45.63 (95% CI: 0.86–92.12) after ≥7 days of admission. Conclusion The pooled estimate of extended spectrum beta-lactamase and carbapenemase producing Enterobacteriaceae were high. This indicates the need for strong mitigation strategies to minimize the spread of multidrug-resistant bacteria at the healthcare facilities.

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Epidemiology, risk factors and outcomes of multidrug-resistant bacteria colonization in a Moroccan medical intensive care unit

Cited by 2 publications

References 0 publications

Microbiological profile of multidrug resistant bacteria before and during COVID-19 in CHU Mohammed VI

Microbiological profile of multidrug resistant bacteria before and during COVID-19 in CHU Mohammed VI

Colonization with extended spectrum beta-lactamase and carbapenemases producing Enterobacteriaceae among hospitalized patients at the global level: A systematic review and meta-analysis

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