Epidemiology, Risk Factors, and Prevention

Bayraktar, Soley; Arun, Banu K.

doi:10.1007/978-3-030-04606-4_4

Cited by 2 publications

(2 citation statements)

References 217 publications

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“…The mechanisms of the previous studies underlying the associations among HRT use, lower BMI, premenopause, and IBC were mainly explained by the effect of these factors on dense breasts and the masking effect or independent increased risk of IBC due to higher breast density. 22 , 25 However, associations between these factors and IBC compared with SBC after adjusting for breast density or stratified by breast density suggested independent associations with IBC.…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors and Mortality Among Women With Interval Breast Cancer vs Screen-Detected Breast Cancer

Song,

Tran,

Kim

et al. 2024

JAMA Netw Open

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ImportanceThe risk factors for interval breast cancer (IBC) compared with those for screen-detected breast cancer (SBC) and their association with mortality outcomes have not yet been evaluated among Korean women.ObjectiveTo evaluate risk factors associated with IBC and survival among Korean women with IBC compared with those with SBC.Design, Setting, and ParticipantsThis retrospective cohort study used data from the Korean National Health Insurance Service Database. Women who participated in a national mammographic breast cancer screening program between January 1, 2009, and December 31, 2012, were included. Mortality outcomes were calculated from the date of breast cancer diagnosis to the date of death or December 31, 2020. Data were analyzed from March 1 to June 30, 2023.ExposureBreast cancer diagnosed within 6 to 24 months after a negative screening result (ie, IBC) or within 6 months after a positive screening result (ie, SBC).Main Outcomes and MeasuresRisk factors and survival rates for IBC and SBC.ResultsThis study included 8702 women with IBC (mean [SD] age, 53.3 [8.6] years) and 9492 women with SBC (mean [SD] age, 54.1 [9.0] years). Compared with SBC, the probability of IBC decreased as mammographic density increased. Lower body mass index, menopausal status, hormone replacement therapy (HRT) use, and lack of family history of breast cancer were associated with a higher likelihood of IBC. When stratified by detection time, younger age at breast cancer diagnosis and family history of breast cancer were associated with an increased likelihood of IBC diagnosed at 6 to 12 months but a decreased likelihood of IBC diagnosed at 12 to 24 months. Overall mortality of IBC was comparable with SBC, but total mortality and cancer-related mortality of IBC diagnosed between 6 and 12 months was higher than that of SBC.Conclusions and RelevanceThe findings of this cohort study suggest that breast density, obesity, and HRT use were associated with IBC compared with SBC. These findings also suggest that higher supplemental breast ultrasound use among Korean women, especially those with dense breasts, could be attributed to a lower incidence of IBC among women with dense breasts compared with women with SBC, due to greater detection. Finally, overall mortality of IBC was comparable with that of SBC.

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Section: Discussionmentioning

confidence: 99%

Section: Jama Network Open | Oncologymentioning

confidence: 99%

Risk Factors and Mortality Among Women With Interval Breast Cancer vs Screen-Detected Breast Cancer

Song,

Tran,

Kim

et al. 2024

JAMA Netw Open

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Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors

Duan,

Jiang,

et al. 2024

PeerJ

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The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family includes CMTM1–8 and CKLF, and they play key roles in the hematopoietic, immune, cardiovascular, and male reproductive systems, participating in the physiological functions, cancer, and other diseases associated with these systems. CMTM family members activate and chemoattract immune cells to affect the proliferation and invasion of tumor cells through a similar mechanism, the structural characteristics typical of chemokines and transmembrane 4 superfamily (TM4SF). In this review, we discuss each CMTM family member’s chromosomal location, involved signaling pathways, expression patterns, and potential roles, and mechanisms of action in pancreatic, breast, gastric and liver cancers. Furthermore, we discuss several clinically applied tumor therapies targeted at the CMTM family, indicating that CMTM family members could be novel immune checkpoints and potential targets effective in tumor treatment.

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Epidemiology, Risk Factors, and Prevention

Cited by 2 publications

References 217 publications

Risk Factors and Mortality Among Women With Interval Breast Cancer vs Screen-Detected Breast Cancer

Risk Factors and Mortality Among Women With Interval Breast Cancer vs Screen-Detected Breast Cancer

Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors

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