Epidemiology, treatment, survival, and prognostic factors of cutaneous mucoepidermoid carcinoma: A distinct entity with an indolent clinical course

Mirza, Fatima N.; Yumeen, Sara; Zogg, Cheryl K.; Mirza, Humza N.; Leventhal, Jonathan S.

doi:10.1016/j.jaad.2020.05.086

Cited by 2 publications

(6 citation statements)

References 5 publications

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“…12 Fatalities are more prevalent in high-grade neoplasms. 12,13 In this regard, predictors of survival include older age (shorter OS and DSS), highgrade lesion (shorter OS), face as lesion site (longer OS and DSS), and surgical resection as a treatment modality (longer OS and DSS). 12 cMEC arising particularly in the external auditory canal is even more rare.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 In this regard, predictors of survival include older age (shorter OS and DSS), highgrade lesion (shorter OS), face as lesion site (longer OS and DSS), and surgical resection as a treatment modality (longer OS and DSS). 12 cMEC arising particularly in the external auditory canal is even more rare. It can present as an asymptomatic mass with or without ear fullness, otalgia, dizziness, tinnitus, and/or otorrhea.…”

Section: Discussionmentioning

confidence: 99%

“…They are typically low‐grade neoplasms (75.5%) that present as asymptomatic or ulcerated nodules in the face (84.3%), followed by the trunk and the extremities. Overall, cMECs have a 5‐year overall survival (OS) and disease‐specific survival (DSS) of 68.2% and 76%, respectively 12 . Fatalities are more prevalent in high‐grade neoplasms 12,13 .…”

Section: Discussionmentioning

confidence: 99%

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Primary mucoepidermoid carcinoma of the external auditory canal with a CRTC1::MAML2 fusion: A case report and a review of literature

et al. 2023

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Mucoepidermoid carcinoma is a malignant neoplasm of exocrine glands that arises predominantly in salivary glands. It is seldom encountered as a primary cutaneous neoplasm, and in those patients, it often involves the external auditory canal. Given their rarity, they can pose a diagnostic challenge and prompt extensive workup. In salivary glands, mucoepidermoid carcinomas commonly harbor CRTC1/3::MAML2 fusions; however, genetic alterations of primary cutaneous neoplasms are less characterized, with previous studies reporting CRTC1 rearrangements in the absence of MAML2 aberrations. Herein, we report a case of a primary cutaneous mucoepidermoid carcinoma of the external auditory canal with a CRTC1::MAML2 rearrangement.We also review the clinical, morphologic, and molecular features of this neoplasm and compare them to those reported in the literature and to histopathologic mimics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary mucoepidermoid carcinoma of the external auditory canal with a CRTC1::MAML2 fusion: A case report and a review of literature

et al. 2023

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“…60,61 In a recent review of the SEER database for the years 1973-2016 searching for tumors coded as 8430/3, a total of 89 cases of skin MEC have been recorded. 62 The tumors occurred at a mean age of 63 years with slight male predominance (55%) and mean age at diagnosis of 63.4 years (range 23-94). Majority of cases were low stage 68%) and low-grade (75.5%).…”

Section: Cutaneous Adenoid Cystic Carcinomamentioning

confidence: 97%

“…The literature on skin MEC is limited to rare case reports (no more than 15 cases have been well documented) 60,61 . In a recent review of the SEER database for the years 1973–2016 searching for tumors coded as 8430/3, a total of 89 cases of skin MEC have been recorded 62 . The tumors occurred at a mean age of 63 years with slight male predominance (55%) and mean age at diagnosis of 63.4 years (range 23–94).…”

Section: Crtc1/3::maml2‐fusion Positive Skin Tumors (Hidradenoma Hidr...mentioning

confidence: 99%

Fusion‐positive skin/adnexal carcinomas

Agaimy

2022

Genes Chromosomes & Cancer

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Gene fusions have been increasingly identified as central events driving oncogenesis in a variety of benign and malignant neoplasms of different histogenesis originating in diverse organs. While some fusion-driven neoplasms may occur at any body site, certain genotypes and their associated phenotypic entities cluster to specific body site/organ, albeit with variable frequencies among anatomic locations. In the last two decades, several skin adnexal entities driven by specific fusions have been described; some of them represent new entities (eg, secretory carcinoma harboring NTRK fusions), while others are old established entities with newly discovered underlying gene fusions (eg, poroid neoplasms harboring NUTM1, YAP1, and WWTR1 fusions).While limited availability of next generation sequencing tools in routine practice has largely limited and delayed discovery of fusions in old entities, the increasing availability of novel immunoantibodies as surrogates to recognize gene fusions (such as NUT and YAP1 immunohistochemistry) represents a relatively cheap, quick, and reliable routine tool for their proper recognition and appropriate classification. This review highlights the main, recently defined skin adnexal carcinomas carrying gene fusions.

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Epidemiology, treatment, survival, and prognostic factors of cutaneous mucoepidermoid carcinoma: A distinct entity with an indolent clinical course

Cited by 2 publications

References 5 publications

Primary mucoepidermoid carcinoma of the external auditory canal with a CRTC1::MAML2 fusion: A case report and a review of literature

Primary mucoepidermoid carcinoma of the external auditory canal with a CRTC1::MAML2 fusion: A case report and a review of literature

Fusion‐positive skin/adnexal carcinomas

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