Epidermal Differentiation in the Human External Auditory Meatus

Marcadores de hiperproliferação na epiderme do meato acústico externo

“…Sanjuan et al 16 studied the expression of cytokeratins 5, 10, 16, 17 and 19 on the epidermis of the normal EAC and in cells of the epidermal EAC from culture. The authors observed that the patterns of expression of these filaments were maintained before and after the culture, including the location of the epidermal layers seen by Lepercque et al 5 and Vennix et al 1 . In the studies which analyzed the EAC epithelium only as control, there was CK 16 expression in the same EAC region, in the suprabasal layers; nonetheless, the au- 1,4,5,8,16 .…”

“…The authors observed that the patterns of expression of these filaments were maintained before and after the culture, including the location of the epidermal layers seen by Lepercque et al 5 and Vennix et al 1 . In the studies which analyzed the EAC epithelium only as control, there was CK 16 expression in the same EAC region, in the suprabasal layers; nonetheless, the au- 1,4,5,8,16 . The cytokeratins were studied in four of the five thors did not report on the place from which the samples were obtained6, except for Broekaert et al 7 who observed CK 16 presence on the fibrocartilaginous annulus, as well as on the juxta-tympanic epithelium (Figure 1).…”

“…As to study designs, 14 (87.5%) were cross-sectional [1][2][3][4][5][6][7][8][9][10][11][12][13][14] and only two (12.5%) were experimental 15,16 . Among all the papers included in this review, five (31.25%) were published with the only goal of analyzing, by means of immunohistochemistry, the epidermis of the normal external auditory meatus 1,4,5,8,16 .…”

“…They were: The Laryngoscope (impact factor in 2005: 1.617), with the paper from Vennix et al [1]1 and the International Journal of Molecular Medicine (impact factor in 2005: 2.090), with the paper from Naim et al [1]2 . After analyzing these papers, we chose the key-words: immunohistochemistry (IMH) and external auditory canal (EAC).…”

“…By means of immunohistochemistry, initially used to diagnose tumors, it is also possible to study the mechanisms of skin migration in the external auditory canal, local immune response, the expression patterns of intermediate filaments, the presence of cytokines and other antigens, as well as the evaluation of new treatment proposals for the diseases that affect the canal [1][2][3] . A deep knowledge of the immunohistochemical patterns of the external auditory canal epidermis directly associated with hyperproliferation helps understand the genesis of the many diseases which affect it (EAC cholesteatoma, benign necrotizing external otitis; epidermal packing), besides contributing to the choice of the best treatment and to establish the prognosis for each disease 3 .…”