Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance.

Frommer, Götz; Vorbrüggen, Gerd; Pasca, G.; Jäckle, Herbert; Volk, Talila

doi:10.1002/j.1460-2075.1996.tb00509.x

Cited by 136 publications

(153 citation statements)

References 48 publications

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“…Egr1 and Egr2 expression can be induced by Fgf4, which is expressed at muscle extremities where the future tendons will attach (Edom-Vovard et al, 2002;Lejard et al, 2010). Of interest, the Drosophila Egr family member Stripe has previously been shown to play a role in fly tendon development (Frommer et al, 1996;Becker et al, 1997), suggesting that a functional analogy exists in the activity of Egr genes in tendon development in both flies and vertebrates (Lejard et al, 2010).…”

Section: Tendon and Ligament Developmentmentioning

confidence: 99%

“Soft” tissue patterning: Muscles and tendons of the limb take their form

Hasson

2011

Developmental Dynamics

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The musculoskeletal system grants our bodies a vast range of movements. Because it is mainly composed of easily identifiable components, it serves as an ideal model to study patterning of the specific tissues that make up the organ. Surprisingly, although critical for the function of the musculoskeletal system, understanding of the embryonic processes that regulate muscle and tendon patterning is very limited. The recent identification of specific markers and the reagents stemming from them has revealed some of the molecular events regulating patterning of these soft tissues. This review will focus on some of the current work, with an emphasis on the roles of the muscle connective tissue, and discuss several key points that addressing them will advance our understanding of these patterning events.

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Section: Tendon and Ligament Developmentmentioning

confidence: 99%

“Soft” tissue patterning: Muscles and tendons of the limb take their form

Hasson

2011

Developmental Dynamics

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“…stripe is expressed in the embryonic epidermis, and mutants exhibit a disruption in muscle attachment and myotubule patterning (Frommer et al, 1996). The stripe protein contains a zinc finger DNA-binding domain that is highly homologous to the EGR1 DBD; amino acids known to make contact with the EGR consensus binding site are completely conserved in stripe.…”

Section: Dnab Can Bind and Repress Mammalian Egr Proteins But Does Nmentioning

confidence: 99%

Drosophila NAB (dNAB) is an orphan transcriptional co‐repressor required for correct CNS and eye development

Clements

Duncan

Milbrandt

2002

Developmental Dynamics

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The mammalian NAB proteins have been identified previously as potent co-repressors of the EGR family of zinc finger transcription factors. Drosophila NAB (dNAB), like its mammalian counterparts, binds EGR1 and represses EGR1-mediated transcriptional activation from a synthetic promoter. In contrast, dNAB does not bind the Drosophila EGR-related protein klumpfuss. dnab RNA is expressed exclusively in a subset of neuroblasts in the embryonic and larval central nervous system (CNS), as well as in several larval imaginal disc tissues. Here, we describe the creation of targeted deletion mutations in the dnab gene and the identification of additional, EMS-induced dnab mutations by genetic complementation analysis. Null alleles in dnab cause larval locomotion defects and early larval lethality (L1-L2). A putative hypomorphic allele in dnab instead causes early adult lethality due to severe locomotion defects. In the dnab -/-CNS, axon outgrowth/guidance and glial development appear normal; however, a subset of eve؉ neurons forms in reduced numbers. In addition, mosaic analysis in the eye reveals that dnab -/-clones are either very small or absent. Similarly, dNAB overexpression in the eye causes eyes to be very small with few ommatidia. These dramatic eye-specific phenotypes will prove useful for enhancer/suppressor screens to identify dnab-interacting genes. Developmental Dynamics 226:67-81, 2003.

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“…Because the COMs come into contact with cardiac cells and HANCs before the HANCs become attached to the heart, we speculate that COMs, in addition to bending the tip of the heart, facilitate its contact with HANCs. The establishment of contact between somatic muscles and their epidermal attachment sites (tendon cells) has been extensively studied (27), revealing the key role of the zinc finger transcription factor Stripe (28) and an RNA-binding protein How (29). We have used both these markers to test whether the HANCs and cardiac cells to which the COMs attach display properties of tendon-like cells.…”

Section: Resultsmentioning

confidence: 99%

Patterning of the cardiac outflow region in Drosophila

Zı́ková

Ponte

Dastugue

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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Specification of bilateral cardiac primordia and formation of the linear heart tube are highly conserved from Drosophila to humans. However, subsequent heart morphogenesis involving nonmesodermal neural crest cells was thought to be specific for vertebrates. Here, we provide evidence that a group of nonmesodermal cells that we have named heart-anchoring cells (HANCs) contribute to heart morphogenesis in Drosophila. We show that the homeobox genes ladybird (lb) known to be involved in diversification of cardiac precursors are expressed in HANCs and required for their specification. Interestingly, the HANCs selectively contact the anterior cardiac cells, which express lb as well. Direct interaction between HANCs and cardiac cells is assisted by a pair of cardiac outflow muscles (COMs), each of which selectively attaches to both the lb-expressing cardiac cells and HANCs. COM muscles seem to ensure ventral bending of the heart tip and together with HANCs determine the spatial positioning of the cardiac outflow region. Experimentally depleted cardiac lb expression leads to the disruption of the contact between the tip of the heart and either the COM muscles or the HANC cells, indicating a pivotal morphogenetic role for the lb expression within the heart. T he understanding of coordinated patterning of different cell types that build functional organs during embryogenesis seems to be an important challenge in developmental biology. Formation of the vertebrate heart provides an example of how the cells of mesodermal (heart primordia) and ectodermal (neural crest cells) origin may contribute to creating a fully functional organ (1). Interestingly, from the molecular and embryological points of view, the early stages of cardiogenesis, including specification of the heart primordia and formation of the beating heart tube, have been preserved from Drosophila to humans (2, 3). In this context, it becomes important to know whether nonmesodermal cells in Drosophila also contribute to a functional heart.The Drosophila heart (dorsal vessel) is a hemolymph-pumping organ that is frontally open and arranged in a repeat pattern of segmental units. At the end of cardiac morphogenesis, the posterior area of the dorsal vessel becomes enlarged and constitutes the definitive heart, whereas the anterior portion has a narrow diameter and is equivalent to the aorta. The heart is composed of two major mesodermal cell types: cardioblasts and pericardial cells (3, 4). The cardioblasts are aligned in two highly ordered rows that form the lumen of the heart. These cells are contractile and express a variety of muscle-specific proteins. The pericardial cells, whose function is unknown so far, are loosely associated with the cardioblasts and do not express any musclespecific marker. Recent studies of genes involved in heart development (5, 6) have revealed discrete subsets of cardioblasts and pericardial cells. According to the expression domains of heart identity genes, in each abdominal segment three types of cardioblasts can be detected, the a...

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Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance.

Cited by 136 publications

References 48 publications

“Soft” tissue patterning: Muscles and tendons of the limb take their form

“Soft” tissue patterning: Muscles and tendons of the limb take their form

Drosophila NAB (dNAB) is an orphan transcriptional co‐repressor required for correct CNS and eye development

Patterning of the cardiac outflow region in Drosophila

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