Epidermal growth factor and basic fibroblast growth factor promote the generation of long-term potentiation in the dentate gyrus of anaesthetized rats

Ishiyama, Jun‐ichi; Saito, Hiroshi; Abe, Kazuho

doi:10.1016/0168-0102(91)90071-6

Cited by 89 publications

(46 citation statements)

References 35 publications

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“…2,3 In the central nervous system, EGF enhances survival and promotes the differentiation of neurons, particularly midbrain dopaminergic neurons. [4][5][6][7] In fact, the ubiquitous presence of EGF receptors (EGFRs) in both developing and mature brain neurons supports the biological significance of the activities of EGF and/or its related molecules in postmitotic neurons. 8,9 Studies utilizing gene-targeting or transgenic strategies to study the EGF gene family have confirmed their importance in prenatal and postnatal development of brain structures as well as in monoamine pharmacology.…”

Section: Introductionmentioning

confidence: 99%

Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development

et al. 2003

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Epidermal growth factor (EGF) and its structurally related proteins are implicated in the developmental regulation of various brain neurons, including midbrain dopaminergic neurons. There are EGF and EGF receptor abnormalities in both brain tissues and blood from schizophrenic patients. We administered EGF to neonatal rats to transiently perturb endogenous EGF receptor signaling and evaluated the neurobehavioral consequences. EGF-treatment-induced transient impairment in tyrosine hydroxylase expression. The animals grew normally, exhibited normal weight increase, glial growth, and gross brain structures, and later lost the tyrosine hydroxylase abnormality. During and after development, however, the rats began to display various behavioral abnormalities. Abnormal sensorimotor gating was apparent, as measured by deficits in prepulse inhibition of acoustic startle. Motor activity and social interaction scores of the EGF-treated animals were also impaired in adult rats, though not in earlier developmental stages. In parallel, there was a significant abnormality in dopamine metabolism in the brain stem of the adult animals. Gross learning ability appeared to be normal as measured by active avoidance. These behavioral alterations, which are often present in schizophrenic models, were ameliorated by subchronic treatment with clozapine. Although the molecular and/or physiologic background(s) of these behavioral abnormalities await further investigation, the results of the present experiment indicate that abnormal EGF receptor stimulation given during limited neonatal stages can result in severe and persistent cognitive/behavioral dysfunctions, which appear only in adulthood.

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Section: Introductionmentioning

confidence: 99%

Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development

et al. 2003

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“…2 In the brain, EGF family members serve as neurotrophic molecules to enhance stem cell proliferation and neuronal differentiation, and influence synaptic plasticity, including hippocampal long-term potentiation. [3][4][5][6] In situ hybridization techniques reveal widespread expression of HB-EGF mRNA in neurons and oligodendrocytes, especially in the cerebellum, hippocampus, cerebral cortex, subventricular area, and brain stem nuclei. 7 TGF␣ mRNA has a similar widespread distribution in the brain.…”

Section: Introductionmentioning

confidence: 99%

Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients

et al. 2002

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Epidermal growth factor (EGF) comprises a structurally related family of proteins containing heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor alpha (TGF␣) that regulates the development of dopaminergic neurons as well as monoamine metabolism. We assessed the contribution of EGF to schizophrenia by measuring EGF family protein levels in postmortem brains and in fresh serum of schizophrenic patients and control subjects. EGF protein levels were decreased in the prefrontal cortex and striatum of schizophrenic patients, whereas the levels of HB-EGF and TGF␣ were not significantly different in any of the regions examined. Conversely, EGF receptor expression was elevated in the prefrontal cortex. Serum EGF levels were markedly reduced in schizophrenic patients, even in young, drug-free patients. Chronic treatment of animals with the antipsychotic drug haloperidol had no influence on EGF levels in the brain or serum. These findings suggest that there is abnormal EGF production in various central and peripheral tissues of patients with both acute and chronic schizophrenia. EGF might thus provide a molecular substrate for the pathologic manifestation of the illness, although additional studies are required to determine a potential link between impaired EGF signaling and the pathology/etiology of schizophrenia.

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“…Evoked potentials were recorded as described in detail in our previous papers (7,8). Male Wistar rats (7 to 9-week-old) were anesthetized with a combination of urethane (1 g/kg, i.p.)…”

Section: Introductionmentioning

confidence: 99%

Involvement of Carbon Monoxide in Long-Term Potentiation in the Dentate Gyrus of Anesthetized Rats

Ikegaya

Saito

Matsuki

1994

Japanese Journal of Pharmacology

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ABSTRACT-To elucidate the role of carbon monoxide (CO) in hippocampal long-term potentiation (LTP), the effect of an inhibitor of heme oxygenase, which produces carbon monoxide, was investigated in the dentate gyrus of anesthetized rats. Administration of zinc protoporphyrin IX (100 nmol, i.c.v.) 30 min before the tetanic stimulation of 30 pulses at 60 Hz attenuated the intensity of LTP. However, this drug did not affect the established LTP. These results suggest that CO participates in the generation of LTP in vivo.

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Epidermal growth factor and basic fibroblast growth factor promote the generation of long-term potentiation in the dentate gyrus of anaesthetized rats

Cited by 89 publications

References 35 publications

Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development

Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development

Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients

Involvement of Carbon Monoxide in Long-Term Potentiation in the Dentate Gyrus of Anesthetized Rats

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