Epidermal growth factor and its receptor in the developing human nervous system

Birecree, Elizabeth; King, Lloyd E.; Nanney, Lillian B.

doi:10.1016/0165-3806(91)90043-i

Cited by 68 publications

(39 citation statements)

References 29 publications

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“…EGF and EGFr are widely distributed in the mammalian peripheral nervous system (Birecree et al, 1991;Werner et al, 19881, especially acting on Schwann cells (Birecree et al, 1991;Eccleston et al, 1991;Kitano et al, 1992;Toma et al, 1992). The presence of EGFr IR in the human cutaneous nerves and SNF has been recently communicated (Vega et al, 199413).…”

Section: Type I and Ii If Proteins: Cytokemtina (Ck)mentioning

confidence: 96%

Immunohistochemistry of human cutaneous Meissner and Pacinian corpuscles

Vega

Haro

Soto

1996

Microsc. Res. Tech.

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Section: Type I and Ii If Proteins: Cytokemtina (Ck)mentioning

confidence: 96%

Immunohistochemistry of human cutaneous Meissner and Pacinian corpuscles

Vega

Haro

Soto

1996

Microsc. Res. Tech.

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“…To the best of our knowledge, this is the first paper to report a different plasma EGF level between PD and ET. Although EGF/EGF-R is both involved in PD and ET [11,[16][17][18][19], our results suggested that there may be different underlying mechanisms which results in the significant different level of plasma EGF between PD and ET. The disease duration of ET in our cohort was 15 years in average.…”

Section: Discussionmentioning

confidence: 73%

Plasma Epidermal Growth Factor Decreased in the Early Stage of Parkinson’s Disease

Jiang¹,

Wang²,

Zhou³

et al. 2015

Aging and disease

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Epidermal growth factor (EGF) is a neurotrophic factor that plays an important role inParkinson's disease (PD). We measured plasma EGF level in PD, essential tremor (ET) and normal controls to investigate whether it changes in PD and whether it is associated with motor and non-motor symptoms of PD. 100 patients with PD, 40 patients with ET as disease control and 76 healthy persons were enrolled in the present study. Motor and non-motor symptoms were assessed by different scales. Plasma EGF levels of three groups were measured by enzyme-linked immunosorbent assay kit. Spearman test and linear logistics regression model were used to test the correlation of EGF with motor and non-motor symptoms of PD. Plasma EGF level was significantly decreased in early PD patients compared with normal control, but not in advanced PD patients. Interestingly, plasma EGF level was significantly increased in advanced PD and total PD patients compared with ET patients, but not in early PD patients. In addition, plasma EGF level was correlated with UPDRS-III scores in PD. Also plasma EGF level was correlated with UPDRS-III scores and NMS scores in early PD. Our results suggested that plasma EGF decreased in the early stage of PD and increased later on in the PD disease course. Also, plasma EGF level was increased significantly in PD compared with ET patients and correlated with motor and non-motor symptoms in early PD.

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“…On the other hand, increasing evidence suggests an involvement of EGF in controlling or regulating Schwann cell biology. In fact, they synthesize EGFr mRNA (Toma et al, 1992), express immunoreactivity for EGFr (Werner et al, 1988;Birecree et al, 1991;Eccleston et al, 1991;Toma et al, 1992), and EGF stimulated them to proliferate in culture (Kitano et al, 1992). Moreover, Toma et al (1992) have shown synthesis and expression of EGFr in perineurial cells.…”

mentioning

confidence: 93%

“…Both EGF and EGFr have been found widely distributed in the central and peripheral nervous system of mammals, including man (Werner et al, 1988;Schaudies et al, 1989;Birecree et al, 1991). In the peripheral nervous system, sensory neurons and satellite glial cells from dorsal root ganglia display immunoreactivity for EGFr (Werner et al, 1988;Birecree et al, 1991). On the other hand, increasing evidence suggests an involvement of EGF in controlling or regulating Schwann cell biology.…”

mentioning

confidence: 96%

“…EGF elicits cell responses by binding to specific receptors (EGFr; see Carpenter, 1987) which also bind transforming growth factor a (TGFa; see Chalazonitis et al, 1992). Both EGF and EGFr have been found widely distributed in the central and peripheral nervous system of mammals, including man (Werner et al, 1988;Schaudies et al, 1989;Birecree et al, 1991). In the peripheral nervous system, sensory neurons and satellite glial cells from dorsal root ganglia display immunoreactivity for EGFr (Werner et al, 1988;Birecree et al, 1991).…”

mentioning

confidence: 97%

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