Epidermal growth factor family in rhesus monkey uterus during the menstrual cycle and early pregnancy

Yue, Zhan‐Peng; Yang, Zeng‐Ming; Li, Shijie; Wang, Hongbin; Harper, M. J. K.

doi:10.1002/(sici)1098-2795(200002)55:2<164::aid-mrd5>3.0.co;2-d

Cited by 17 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both EGF and EGFR are expressed in pregnant uteri of various mammalian species such as human (Chegini et al, 1986;Smith et al, 1991), baboon (Slowey et al, 1994), rhesus monkey (Yue et al, 2000), rabbit (Hofmann and Anderson, 1990), mouse (Das et al, 1994) and pigs (Kim et al, 2009(Kim et al, , 2001Wollenhaupt et al, 2004;Kennedy et al, 1994), and it is present at high concentration in various body fluids. In pigs, EGF is expressed predominantly by uterine GE and columnar epithelial cells of the oviduct (Kennedy et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Epidermal growth factor stimulates proliferation and migration of porcine trophectoderm cells through protooncogenic protein kinase 1 and extracellular-signal-regulated kinases 1/2 mitogen-activated protein kinase signal transduction cascades during early pregnancy

Jeong

Kim

Bazer

et al. 2013

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Epidermal growth factor stimulates proliferation and migration of porcine trophectoderm cells through protooncogenic protein kinase 1 and extracellular-signal-regulated kinases 1/2 mitogen-activated protein kinase signal transduction cascades during early pregnancy

Jeong

Kim

Bazer

et al. 2013

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

“…The uteri of pregnant mice, rat, pigs and monkeys have been shown to express EGFR, some EGFR ligands and CaBP‐9k (Slowey et al. 1994; Yue et al. 2000; Kim et al.…”

Section: Discussionmentioning

confidence: 99%

Uterine Expression of Epidermal Growth Factor Family During the Course of Pregnancy in Pigs

Kim¹,

Lee²,

Hyun

et al. 2009

Reprod Domestic Animals

View full text Add to dashboard Cite

To stably maintain pregnancy, several genes are expressed in the uterus. In particular, the endometrial expression of genes encoding growth factors appears to play a key role in maternal-foetal communication. The previous studies characterized the endometrial expression kinetics of the genes encoding epidermal growth factor (EGF), its receptor (EGFR), transforming growth factor-alpha (TGF-alpha), amphiregulin (Areg), heparin-binding (Hb) EGF and calbindin-D9k (CaBP-9k) in pigs during implantation. Here, we further characterized the expression patterns of these molecules during the entire porcine pregnancy. Porcine uteri were collected at pregnancy days (PD) 12, 15, 30, 60, 90 and 110 and subjected to RT-PCR. EGF and EGFR showed similar expression patterns, being highly expressed around implantation and then disappearing. TGF-alpha and Areg expression levels rose steadily until they peaked at PD30, after which they gradually decreased to PD12 levels. This Areg mRNA expression pattern was confirmed by real-time PCR and similar Areg protein expression patterns were observed. Immunohistochemical analysis of PD60 uteri revealed Areg in the glandular and luminal epithelial cells. Hb EGF was steadily expressed throughout the entire pregnancy, while CaBP-9k was expressed strongly on PD12, and then declined sharply on PD15 before recovering slightly for the remainder of the pregnancy. Thus, the EGF family may play a key role during implantation in pigs. In addition, CaBP-9k may help to maintain uterine quiescence during pregnancy by sequestering cytoplasmic Ca(2+).

show abstract

“…Baboons display a similar pattern in which HBEGF protein levels are highest 5–10 days post-ovulation (Leach et al, 2001). In rhesus monkeys, HBEGF increases during the proliferative phase, peaks during the window of implantation, and declines thereafter (Yue et al, 2000). Its maximal expression during the mid-secretory phase supports the view that HBEGF is a key regulator of blastocyst implantation.…”

Section: Early Cyclical Regulation Of Hbegf In the Endometriummentioning

confidence: 99%

Diverse functions of HBEGF during pregnancy

Jessmon

Leach

Armant

2009

Molecular Reproduction Devel

View full text Add to dashboard Cite

SUMMARYThe establishment of pregnancy requires an intimate physical interaction and a molecular dialogue between the conceptus and the maternal reproductive tract that commences at implantation and continues until the placenta is formed and fully functional. Failure of the regulatory processes that ensure the fidelity of this relationship can precipitate a catastrophic pregnancy loss. One of the earliest identified molecular mediators of blastocyst implantation is heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF), which signals between the endometrium and implanting trophoblast cells to synchronize their corresponding developmental programs. HBEGF expression by trophoblast cells of the developing placenta appears to regulate extravillous differentiation and provide cytoprotection in a sometimes-hostile environment. This versatile member of the EGF signaling system will be examined in light of its associations with key events during early pregnancy.

show abstract

Epidermal growth factor family in rhesus monkey uterus during the menstrual cycle and early pregnancy

Cited by 17 publications

References 33 publications

Epidermal growth factor stimulates proliferation and migration of porcine trophectoderm cells through protooncogenic protein kinase 1 and extracellular-signal-regulated kinases 1/2 mitogen-activated protein kinase signal transduction cascades during early pregnancy

Epidermal growth factor stimulates proliferation and migration of porcine trophectoderm cells through protooncogenic protein kinase 1 and extracellular-signal-regulated kinases 1/2 mitogen-activated protein kinase signal transduction cascades during early pregnancy

Uterine Expression of Epidermal Growth Factor Family During the Course of Pregnancy in Pigs

Diverse functions of HBEGF during pregnancy

Contact Info

Product

Resources

About