Epidermal Growth Factor Inhibits Somatostatin-Induced Apoptosis

Expression of porcine epidermal growth factor in Pichia pastoris and its biology activity in early-weaned piglets

“…Previous reports demonstrated that intraperitoneal or orogastric EGF administration increased mucosal DNA synthesis, mitotic activity and inhibited somatostatin-induced apoptosis in the small intestine of young animals (Malo and Menard, 1982;O'Loughlin et al, 1985). Thompson (1999) has found that the effect of EGF is greater in the crypt than in the villus of enterocytes. Moreover, orally administered EGF could restore the villus height in neonatal pigs infected with rotavirus (Zijlstra et al, 1994).…”

Regulation of intestinal regeneration: New insights

“…Regulation of apoptosis play an important role in the overall proliferation response (Helmrath et al, 1998;Kucharzik et al, 1999;Thompson, 1998Thompson, , 1999). This appears to be another mechanism by which EGF influences intestinal growth and adaptation (Helmrath et al, 1998).…”

“…Waved-2 mice with a defective EGF receptor have attenuated intestinal adaption after resection (Helmrath et al, 1997). Apoptosis in the intestine adjacent to the patched defect is inhibited by EGF and stimulated by somatostatin (Thompson, 1998(Thompson, , 1999. Apoptosis is regulated in both crypt and villus compartments (Jones and Gores, 1997).…”

Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms

“…SST and its analogues were demonstrated to have direct (i.e. SST acts on the tumour cell itself and not via other tissues such as vessels) anti-proliferative effects in a variety of tumour cells by inhibiting the mitogenic signalling of growth factor receptor kinases, but also by inducing apoptosis (Thompson 1999, Liu et al 2000, Lahlou et al 2004. They also may inhibit the secretion of insulin-like growth factor-I, which has been thought to be involved in recurrence, growth and aggressiveness of some endocrine and non-endocrine tumours (Furukawa et al 2005).…”