Epidermal growth factor receptor 2 immunoexpression in gastric cells of domestic cats with H. heilmannii infection

Sousa, Daniela A.; Silva, Kássia Valéria Gomes Coelho da; Cascon, Clarice M.; Mello, Marcela Freire Valim de; Leite, Juliana da Silva; Fonseca, Ana Beatriz Monteiro; El-Jaick, Kênia Balbi; Ferreira, Ana Maria Reis

doi:10.1016/j.acthis.2019.03.004

Cited by 8 publications

(6 citation statements)

References 38 publications

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“…28,29 Despite the observation of a histologic mild gastritis, all animals were clinically healthy. 28 This suggests that pet-associated gastric Helicobacters cause little or no harm in their natural host, which is in contrast to other members of the NHPH group. 29 However, Takemura et al 30 Furthermore, novel enterohepatic Helicobacter species were identified in both marine and terrestrial zoo mammals.…”

Section: Pre S En Ce Of Non -H Elicobac Ter Pylori Helicobac Ter S mentioning

confidence: 96%

“…They showed that all animals were predominantly infected with Helicobacter heilmannii, the most prevalent feline Helicobacter species. 28 This suggests that pet-associated gastric Helicobacters cause little or no harm in their natural host, which is in contrast to other members of the NHPH group. 28 This suggests that pet-associated gastric Helicobacters cause little or no harm in their natural host, which is in contrast to other members of the NHPH group.…”

Section: Pre S En Ce Of Non -H Elicobac Ter Pylori Helicobac Ter S mentioning

confidence: 99%

“…In 2018, Sousa et al 28 investigated the presence of NHPH in the gastric mucosa of cats. They showed that all animals were predominantly infected with Helicobacter heilmannii, the most prevalent feline Helicobacter species.…”

Section: Pre S En Ce Of Non -H Elicobac Ter Pylori Helicobac Ter S mentioning

confidence: 99%

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Review: Other Helicobacter species

Ménard

Smet

2019

Helicobacter

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This article is a review of the most important, accessible, and relevant literature published between April 2018 and April 2019 in the field of Helicobacter species other than Helicobacter pylori. The initial part of the review covers new insights regarding the presence of gastric and enterohepatic non‐H. pylori Helicobacter species (NHPH) in humans and animals, while the subsequent section focuses on the progress in our understanding of the pathogenicity and evolution of these species. Over the last year, relatively few cases of gastric NHPH infections in humans were published, with most NHPH infections being attributed to enterohepatic Helicobacters. A novel species, designated “Helicobacter caesarodunensis,” was isolated from the blood of a febrile patient and numerous cases of human Helicobacter cinaedi infections underlined this species as a true emerging pathogen. With regard to NHPH in animals, canine/feline gastric NHPH cause little or no harm in their natural host; however they can become opportunistic when translocated to the hepatobiliary tract. The role of enterohepatic Helicobacter species in colorectal tumors in pets has also been highlighted. Several studies in rodent models have further elucidated the mechanisms underlying the development of NHPH‐related disease, and the extra‐gastric effects of a Helicobacter suis infection on brain homeostasis was also studied. Comparative genomics facilitated a breakthrough in the evolutionary history of Helicobacter in general and NHPH in particular. Investigation of the genome of Helicobacter apodemus revealed particular traits with regard to its virulence factors. A range of compounds including mulberries, dietary fiber, ginseng, and avian eggs which target the gut microbiota have also been shown to affect Helicobacter growth, with a potential therapeutic utilization and increase in survival.

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Section: Pre S En Ce Of Non -H Elicobac Ter Pylori Helicobac Ter S mentioning

confidence: 96%

Section: Pre S En Ce Of Non -H Elicobac Ter Pylori Helicobac Ter S mentioning

confidence: 99%

See 1 more Smart Citation

Review: Other Helicobacter species

Ménard

Smet

2019

Helicobacter

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“…Paraffin sections were made as previously described (39,40). After deparaffinization, sections were immersed in 100% ethanol, 96% ethanol, and 75% ethanol, and subjected to heat-induced antigen retrieval at 120°C for 10 min, After cooling to room temperature, each slide was incubated with the primary antibody overnight at 4C, then incubated with the secondary antibody for 1 h. Color development was produced using DAB staining for 5 min and hematoxylin counterstained for 1 min.…”

Section: Semi-quantitative Immunohistochemistrymentioning

confidence: 99%

SAMD9 Is Relating With M2 Macrophage and Remarkable Malignancy Characters in Low-Grade Glioma

Zhang

Bao

et al. 2021

Front. Immunol.

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Immunoreactions regulated by TAMs (Tumor-associated macrophages) play a pivotal role in tumorigenesis and metastasis. In recent decades, treatments based on immune regulation have achieved revolutionary breakthroughs in cancer targeted therapies. The phenotypes of TAMs in gliomas are more heterogeneous and inherently complex than can be simply defined by classification into the M1 and M2 polarized states. The detailed mechanisms surrounding infiltrating macrophage phenotype and glioma characteristics remain undefined. SAMD9 (Sterile Alpha Motif Domain-Containing Protein 9) was found to be highly expressed in glioma and closely related to histological and genetic features in CGGA and TCGA databases. Simultaneously, we present evidence to show that there was a positive association between SAMD9 and malignancy characters in LGG. Univariable and Multivariate proportional hazard Cox analysis showed that SAMD9 was an independent prognostic factor for LGG. Surprisingly, Gene Ontology (GO) analysis showed SAMD9 expression level was remarkably well correlated with immunological responses and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis supported the connection with immune responses and tumorigenesis. Immune infiltration analysis demonstrated that high SAMD9 expression resulted in an accumulation of macrophages by CIBERSORT and TIMER databases, especially positively related to macrophage total marker gene AIF1 and Macrophage M2 marker gene CD163. IHC staining further indicated a high correlation of SAMD9 with those specific macrophage markers in the immune response. Human THP-1 cells were induced into M2 macrophages, which were then co-cultured with LN229 cells. Silencing of SAMD9 by shRNA in LN229 cells attenuated the infiltration abilities of M2 macrophage. SAMD9 explored immune response via relating of M2 macrophage in vitro. Our results revealed SAMD9 acted as the malignancy characters in LGG, enrichment with M2 macrophage.

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“…A statistically significant association between H. heilmannii infection and HER‐2 expression in the lateral membrane of gastric surface cells was noted. As H. heilmannii has a tropism for parietal cells as well, HER‐2 expression was also abundantly present in the plasma membrane of this cell type 22 . Another study highlighted that long‐term H. suis infection in mice does not only induce gastric MALT lymphoma, but also hepatic and pulmonary lymphoma.…”

Section: Pathogenesis Of Non‐helicobacter Pylori Helicobacter Infectionsmentioning

confidence: 99%

Review: Other Helicobacter species

Smet

Ménard

2020

Helicobacter

View full text Add to dashboard Cite

This review covers the most important, accessible, and relevant literature published between April 2019 and April 2020 in the field of non‐Helicobacter pylori Helicobacter species (NHPH). The initial part of the review covers new insights regarding the presence of gastric and enterohepatic NHPH in humans and animals, while the subsequent section focuses on the progress in our understanding of animal models, the pathogenicity and omics of these species. Over the last year, the clinical relevance of gastric NHPH infections in humans was highlighted. With regard to NHPH in animals, the ancestral source of Helicobacter suis was further established showing that Cynomolgus macaques are the common ancestor of the pig‐associated H. suis population, and 3 novel Helicobacter species isolated from the gastric mucosa of red foxes were described. "Helicobacter burdigaliensis" sp nov. and "Helicobacter labetoulli" sp nov. were proposed as novel enterohepatic Helicobacter species associated with human digestive diseases. An analysis of Helicobacter cinaedi recurrent infections in humans proposed long‐term antibiotic therapies. Several studies using rodent models further elucidated the mechanisms underlying the development of NHPH‐related disease, as well as intestinal immunity in inflammatory bowel disease models. Omics approaches supported Helicobacteraceae taxonomy and unraveled the transcriptomic signatures of H. suis and Helicobacter heilmannii upon adherence to the human gastric epithelium. With regard to virulence, data showed that the nuclear remodeling promoted by cytolethal distending toxin of Helicobacters involves the MAFB oncoprotein and is associated with nucleoplasmic reticulum formation in surviving cells.

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Epidermal growth factor receptor 2 immunoexpression in gastric cells of domestic cats with H. heilmannii infection

Cited by 8 publications

References 38 publications

Review: Other Helicobacter species

Review: Other Helicobacter species

SAMD9 Is Relating With M2 Macrophage and Remarkable Malignancy Characters in Low-Grade Glioma

Review: Other Helicobacter species

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