Epidermal growth factor receptor is a predictor of tumor response in locally advanced rectal cancer patients treated with preoperative radiotherapy

Giralt, Jordi; Eraso, Aranzazu; Torres, Irianna; Roselló, J.; Espín, Eloi; Ares, Carmen; Lara, Francisco Javier Pérez; Armengol, Manel

doi:10.1016/s0360-3016(01)01842-9

Cited by 13 publications

(9 citation statements)

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“…Preoperative RCT can reduce tumor mass in rectal carcinomas and improve surgery efficacy, although the magnitude of this benefit is relatively small. Understanding the reasons for partial response to preoperative RCT is of utmost importance and numerous studies have already addressed this issue [2,8,9,14,19,20,23,30,44]. It was shown that radiotherapy may induce changes at the genetic level [21,22], particularly in those genes regulating proliferation, apoptosis, and tissue repair.…”

Section: Discussionmentioning

confidence: 99%

Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy

et al. 2005

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The purpose of the study is to highlight oncocytic modifications in rectal adenocarcinomas and evaluate a possible correlation with preoperative radiochemotherapy (RCT). Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200-225 mg/m(2)) and 44-46 Gy in 22-23 fractions, were studied. All patients underwent biopsy before RCT. Surgery was performed within 6 weeks after RCT. In all cases oncocytic modifications were searched for on hematoxylin and eosin (H&E) and at immunohistochemistry using an antimitochondrial antibody. In addition, in two cases, both pre- and post-RCT tissues were examined at electron microscopy. All tumors were adenocarcinomas. In pre-RCT biopsies, oncocytic changes were difficult to find on H&E, while the antimitochondrial antibody strongly stained numerous neoplastic cells (mean 48.4%). In post-RCT surgical specimens, oncocytic changes were detected in 24 out of 28 cases on H&E and the antimitochondrial antibody stained most of the residual neoplastic cells (mean 76.7%). Ultrastructural examination revealed large and bizarre mitochondria inside tumor cells both in pre- and post-RCT tissues. In conclusion, the present data suggest that rectal adenocarcinomas are "mitochondrion-rich" tumors. After preoperative RCT, residual neoplastic cells acquire a definite oncocytic phenotype.

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Section: Discussionmentioning

confidence: 99%

Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy

et al. 2005

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“…Similarly, overexpression of the EGFR has been shown to correlate with lower tumor control rates after irradiation in different primary tumors, including rectal carcinoma [16,17,20], esophageal carcinoma [19], head and neck carcinomas [7,13,26] or cervical carcinoma [30]. High expression of EGFR was shown to be associated with intrinsic radioresistance in experimental studies [4] and in vitro [24].…”

Section: Discussionmentioning

confidence: 99%

Epidermal Growth Factor Receptor as a Predictor of Tumor Response to Preoperative Chemoradiation in Locally Advanced Gastric Carcinoma

et al. 2008

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“…30 Furthermore, the majority of studies rely on immunohistochemistry (IHC) of formalin-fixed, paraffin-embedded tissue, which has certain limitations. 31,32 A comparison between studies often is difficult because of interobserver variation and lack of standardization. These limitations concerning tumor heterogeneity and IHC might be overcome by blood analysis for germline polymorphisms, as presented in this study.…”

Section: Discussionmentioning

confidence: 99%