Epidermal hydration levels in patients with rosacea improve after minocycline therapy

Raghallaigh, Síona Ní; Powell, Frank C.

doi:10.1111/bjd.12770

Cited by 33 publications

(38 citation statements)

References 34 publications

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“…Wu et al had also found similar results with increased TEWL and decreased corneous layer water content in rosacea patients 16. But Raghallaigh et al17 found epidermal oil content was slightly higher in papulopustular rosacea patients in comparison to healthy subjects with no significance (P>0.05). In our study, we had decreased epidermal oil content and it is probably because the healthy controls we enrolled had relatively higher oily skin ratios.…”

Section: Discussionmentioning

confidence: 93%

Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris

et al. 2016

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Objective:To evaluate the clinical characteristics and epidermal barrier function of papulopustular rosacea by comparing with acne vulgaris.Methods:Four hundred and sixty-three papulopustular rosacea patients and four hundred and twelve acne vulgaris patients were selected for the study in Xiangya Hospital of Central South University from March 2015 to May 2016. They were analyzed for major facial lesions, self-conscious symptoms and epidermal barrier function.Results:Erythema, burning, dryness and itching presented in papulopustular rosacea patients were significantly higher than that in acne vulgaris patients (P<0.001). The clinical scores of erythema, burning, dryness and itching in papulopustular rosacea patients were significantly higher than those in acne vulgaris patients (P<0.001). The water content of the stratum cornuem and skin surface lipid level were both significantly lower in papulopustular rosacea patients than that of the acne vulgaris patients (P<0.001) and healthy subjects (P<0.001); Water content of the stratum cornuem and skin surface lipid level were higher in acne vulgaris patients in comparison with that of healthy subjects (P>0.05, P<0.001; respectively). Transepidermal water loss was significantly higher in papulopustular rosacea patients than that of acne vulgaris patients and healthy subjects (P<0.001); transepidermal water loss was lower in skin of acne vulgaris patients than that of healthy subjects (P<0.001).Conclusion:Erythema, burning, dryness and itching are the characteristics of papulopustular rosacea, which makes it different from acne vulgaris. The epidermal barrier function was damaged in papulopustular rosacea patients while not impaired in that of acne vulgaris patients.

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Section: Discussionmentioning

confidence: 93%

Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris

et al. 2016

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“…Ammonia‐induced alkalization activates stool enzymes lipase and tryptase leading to irritation . In addition, even in acne and rosacea the mean facial SC pH is significantly increased …”

Section: Ph In Inflammatory Skin Diseases and Itchmentioning

confidence: 99%

pH in nature, humans and skin

Proksch

2018

The Journal of Dermatology

416

273

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The pH plays an important physiological role in nature and humans. pH varies from 1 to 8 in human organs with tight regulation in blood and epithelia of barrier organs. The physiological pH of the stratum corneum is 4.1-5.8 and several mechanisms contribute to its formation: filaggrin degradation, fatty acid content, sodium-hydrogen exchanger (NHE1) activation and melanosome release. First, the acidic pH of the stratum corneum was considered to present an antimicrobial barrier preventing colonization (e.g. by Staphylococcus aureus and Malassezia). Later on, it was found that the pH influences skin barrier function, lipid synthesis and aggregation, epidermal differentiation and desquamation. Enzymes of ceramide metabolism (e.g. β-glucocerebrosidase or acid sphingomyelinase) as well as proteases (e.g. chymotryptic enzyme or cathepsin D linked to epidermal differentiation and desquamation) are regulated by the pH. Experimental disruption of the physical barrier leads to an increase of pH, returning to normal levels only after many hours. Inflammatory skin diseases and diseases with an involvement of the epidermis exhibit a disturbed skin barrier and an increased pH. This is known for atopic dermatitis, irritant contact dermatitis, ichthyosis, rosacea and acne, but also for aged and dry skin. Normalizing the pH by acidification through topical treatment helps to establish a physiological microbiota, to repair skin barrier, to induce epidermal differentiation and to reduce inflammation.

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“…[14][15][16] Reduced stratum corneum hydration and altered skin surface pH were previously noted in patients with rosacea. However, some epidermal changes such as parakeratosis, acanthosis, and exocytosis of inflammatory cells into the epidermis were more common in the PPR cases than in the ETR cases, which may explain the more evident dermal inflammatory reactions in the PPR subtype.…”

Section: Discussionmentioning

confidence: 84%

Histopathological Analysis of 226 Patients With Rosacea According to Rosacea Subtype and Severity

Lee

Jung

Lee

et al. 2016

The American Journal of Dermatopathology

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Epidermal hydration levels in patients with rosacea improve after minocycline therapy

Cited by 33 publications

References 34 publications

Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris

Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris

pH in nature, humans and skin

Histopathological Analysis of 226 Patients With Rosacea According to Rosacea Subtype and Severity

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