Epidermal Mast Cells

Green, Rollin M.; Cordero, Alejandro; Winkelmann, R. K.

doi:10.1001/archderm.1977.01640020038005

Cited by 22 publications

(9 citation statements)

References 12 publications

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“…This is likely enabled by the lack of the basement membrane in the invasive growth phase, allowing penetration of the mast cells into the tumor cell mass. Intraepidermal mast cells have also been reported in skin ulcers [40] and chronic inflammation [41], which are also common features in melanoma. The close contact between the mast cells and the tumor cells enables direct interaction of the cells and may affect tumor growth.…”

Section: Discussionmentioning

confidence: 96%

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Siiskonen

Poukka

Bykachev³

et al. 2015

Melanoma Research

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The role of mast cells in cutaneous melanoma remains unclear. Tryptase and chymase are serine proteinases and major proteins in mast cell secretory granules. Therefore, this study aimed to investigate the presence of tryptase and chymase mast cells in benign and malignant cutaneous melanocytic lesions and in lymph node metastases of melanomas. The presence of positively stained mast cells was correlated with clinicopathological characteristics in invasive melanomas. Paraffin-embedded sections of 28 benign (13 intradermal, 10 compound, and five junctional nevi) and 26 dysplastic nevi, 15 in-situ melanomas, 36 superficially (pT1, Breslow's thickness<1 mm), and 49 deeply (pT4, Breslow's thickness>4 mm) invasive melanomas and 30 lymph node metastases were immunohistochemically stained for mast cell tryptase and chymase, and immunopositive cells were counted using the hotspot counting method. The mean count of tryptase and chymase mast cells was lower in invasive melanomas compared with in-situ melanomas and dysplastic and benign nevi. In deeply invasive melanomas, the difference was statistically significant compared with dysplastic nevi (P=0.003 for tryptase and P=0.009 for chymase) and in-situ melanomas (0.043 for tryptase). Low numbers of tryptase mast cells were associated with poor overall survival (P=0.031) in deeply invasive melanomas and with a more advanced stage (T1b, P=0.008) in superficially invasive melanomas. Low numbers of chymase mast cells were associated with microsatellites (P=0.017) in deeply invasive melanomas. The results suggest that these serine proteinases of mast cells may be protective in the pathogenesis of melanoma.

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Section: Discussionmentioning

confidence: 96%

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Siiskonen

Poukka

Bykachev³

et al. 2015

Melanoma Research

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“…In the normal skin, mast cells are predominantly located in the upper dermis but only occasionally inside or in contact with the epidermis. However, the number of mast cells is increased in the papillary dermis and in contact with the epidermis in chronic inflammatory skin diseases and in leg ulcers [Green et al, 1977; Bolton and Montagna, 1993; Harvima et al, 1993; Huttunen et al, 2000]. In addition, mast cells have been linked to skin diseases leading to dermal‐epidermal separation and blister formation [Briggaman et al, 1984; Kaminska et al, 1999a,b; D'Auria et al, 2000].…”

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confidence: 99%

Zinc finger gene fez‐like functions in the formation of subplate neurons and thalamocortical axons

Hirata

Suda²,

Nakao

et al. 2004

Developmental Dynamics

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161

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fez-like (fezl) is a forebrain-expressed zinc finger gene required for the formation of the hypothalamic dopaminergic and serotonergic (monoaminergic) neurons in zebrafish. To reveal its function in mammals, we analyzed the expression of the mouse orthologue of fezl and generated fezl-deficient mice by homologous recombination. Mouse fezl was expressed specifically in the forebrain from embryonic day 8.5. At mid-gestation, fezl expression was detected in subdomains of the forebrain, including the dorsal telencephalon and ventral diencephalon. Unlike the zebrafish fezl mutant too few, the fezl-deficient mice displayed normal development of hypothalamic monoaminergic neurons, but showed abnormal "hyperactive" behavior. In fezl -/-mice, the thalamocortical axons (TCA) were reduced in number and aberrantly projected to the cortex. These mutants had a reduced number of subplate neurons, which are involved in guiding the TCA from the dorsal thalamus, although the subplate neurons were born normally. These results suggest that fezl is required for differentiation or survival of the subplate neurons, and reduction of the subplate neurons in fezl-deficient mice leads to abnormal development of the TCA, providing a possible link between the transcriptional regulation of forebrain development and hyperactive behavior. Developmental Dynamics 230: 546 -556, 2004.

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“…Mast cells and their proteolytic enzymes have been suggested to play a marked role in blistering skin diseases characterized by dermal–epidermal separation 1–3 . In addition, mast cells can be found in contact with the epidermis or even be inside the epidermis in chronic inflammatory skin diseases and chronic leg ulcers 4–7 . As mast cell mediators, e.g.…”

mentioning

confidence: 99%

“…[1][2][3] In addition, mast cells can be found in contact with the epidermis or even be inside the epidermis in chronic inflammatory skin diseases and chronic leg ulcers. [4][5][6][7] As mast cell mediators, e.g. histamine, heparin and tumour necrosis factor-a, and HMC-1 mast cell sonicate have been shown to inhibit keratinocyte proliferation and epithelium growth in vitro, [8][9][10][11][12][13] mast cells have been assumed to be involved in controlling the growth of the epidermis.…”

mentioning

confidence: 99%

Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors

Huttunen¹,

Harvima²

2005

Br J Dermatol

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Epidermal Mast Cells

Cited by 22 publications

References 12 publications

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma

Zinc finger gene fez‐like functions in the formation of subplate neurons and thalamocortical axons

Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors

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