Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring

Bandodkar, Amay J.; Molinnus, Denise; Mirza, Omar; Guinovart, Tomàs; Windmiller, Joshua Ray; Valdés‐Ramírez, Gabriela; Andrade, Francisco J.; Schöning, Michael J.; Wang, Joseph

doi:10.1016/j.bios.2013.11.039

Cited by 433 publications

(311 citation statements)

References 33 publications

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“…Despite significant progress made in printed and flexible biosensors in the field, a majority of wearable devices focus on monitoring of physical activity or selected electrophysiological parameters, providing only limited information regarding physiological changes of complex homeostatic responses (4)(5)(6)(7)(8)(9)(10). Wearable chemical sensors offer great opportunities for collecting physiological information at the molecular level (3,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Recently research advances have resulted in a variety of wearable sweat sensors that can be used for real-time analysis of sweat biomarkers including electrolytes, metabolites, and heavy metals (11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

mentioning

confidence: 99%

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform

Emaminejad

Gao

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

668

583

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Perspiration-based wearable biosensors facilitate continuous monitoring of individuals' health states with real-time and molecular-level insight. The inherent inaccessibility of sweat in sedentary individuals in large volume (≥10 μL) for on-demand and in situ analysis has limited our ability to capitalize on this noninvasive and rich source of information. A wearable and miniaturized iontophoresis interface is an excellent solution to overcome this barrier. The iontophoresis process involves delivery of stimulating agonists to the sweat glands with the aid of an electrical current. The challenge remains in devising an iontophoresis interface that can extract sufficient amount of sweat for robust sensing, without electrode corrosion and burning/causing discomfort in subjects. Here, we overcame this challenge through realizing an electrochemically enhanced iontophoresis interface, integrated in a wearable sweat analysis platform. This interface can be programmed to induce sweat with various secretion profiles for real-time analysis, a capability which can be exploited to advance our knowledge of the sweat gland physiology and the secretion process. To demonstrate the clinical value of our platform, human subject studies were performed in the context of the cystic fibrosis diagnosis and preliminary investigation of the blood/sweat glucose correlation. With our platform, we detected the elevated sweat electrolyte content of cystic fibrosis patients compared with that of healthy control subjects. Furthermore, our results indicate that oral glucose consumption in the fasting state is followed by increased glucose levels in both sweat and blood. Our solution opens the possibility for a broad range of noninvasive diagnostic and general population health monitoring applications.W earable biosensors have received considerable attention owing to their great promise for a wide range of clinical and physiological applications (1-10). Despite significant progress made in printed and flexible biosensors in the field, a majority of wearable devices focus on monitoring of physical activity or selected electrophysiological parameters, providing only limited information regarding physiological changes of complex homeostatic responses (4-10). Wearable chemical sensors offer great opportunities for collecting physiological information at the molecular level (3,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Recently research advances have resulted in a variety of wearable sweat sensors that can be used for real-time analysis of sweat biomarkers including electrolytes, metabolites, and heavy metals (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). We recently demonstrated a fully integrated wearable sensing system for real-time monitoring of multiple analytes in human perspiration during physical exercise which allows accurate measurement of sweat analytes through signal processing and calibration (16).The inherent inaccessibility of sweat in sedentary individuals in large volume (≥10 μL) for on-demand and in situ analysis remains to limit our ...

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mentioning

confidence: 99%

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform

Emaminejad

Gao

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

668

583

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“…Therefore, the fabri cated or printed electrodes will be modified with respective ionophore/ion selective membrane cocktails for recognition of the target ion in the biofluid. [168] All these electrode reactions will be measured using a potentiostat. Potentiometric measurements rely on the relationship between ion concentration and the electrochemical potential of the electrode.…”

Section: Wearable Electrochemical Sensorsmentioning

confidence: 99%

Nanomaterial‐Enabled Wearable Sensors for Healthcare

Yao

Swetha

Zhu

2017

Adv Healthcare Materials

469

296

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humidity level, and concentration of harmful gases, and airborne particulates can provide valuable information for the prediction, management, and treatment of chronic diseases. [4,5] In addition to the applications in wearable health monitoring, continuous tracking of daily and sports activities can offer an efficient way to assess the well-being and athletic performances. [6] In order to ensure a robust and conformal contact with the curvilinear, coarse, and dynamic surface of skin without impeding daily activities, the wearable sensor should have low modulus and high stretchability. The epidermis has a modulus of 140-600 kPa while the dermis has an even lower modulus of 2-80 kPa. [7] Skin itself can be stretched elastically up to 15% and with the help of wrinkles and creases, the overall stretchability can reach as high as 100% during daily motions. [8] In addition to good wearability, wearable sensors should be highly sensitive, lightweight, low-cost, and with low power consumption. To achieve these features, nanomaterials that are compliant, possessing larger surface area and exceptional material properties, and compatible with low-cost fabrication processes are widely employed as building blocks for developing wearable sensors.In this review, we start from a brief overview of nanomaterials, their related structural designs and fabrication processes (Section 2). Following that, recent advances of nanomaterialenabled wearable sensors including temperature, electrophysiological, strain, tactile, electrochemical, and other sensors will be summarized (Section 3). A survey on the integration of multiple sensors and other components into wearable systems will be given in Section 4. The application of nanomaterialenabled wearable sensors for healthcare including health monitoring, activity tracking, and electronic skin will be presented in Section 5. The challenges and opportunities will be discussed at the end. Nanomaterials, Structural Designs, and Fabrication ProcessesNanomaterials can be classified into two categories-top-down fabricated ones and bottom-up synthesized ones. [9] The focus of this review is on the wearable sensors based on bottom-up synthesized nanomaterials. Nanomaterials can be synthesized into various dimensions, from 0D such as metallic nanoparticles (NPs), to 1D such as carbon nanotubes (CNTs), and metallic nanowires (NWs), to 2D such as graphene and transition metal Highly sensitive wearable sensors that can be conformably attached to human skin or integrated with textiles to monitor the physiological parameters of human body or the surrounding environment have garnered tremendous interest. Owing to the large surface area and outstanding material properties, nanomaterials are promising building blocks for wearable sensors. Recent advances in the nanomaterial-enabled wearable sensors including temperature, electrophysiological, strain, tactile, electrochemical, and environmental sensors are presented in this review. Integration of multiple sensors for multimodal sensing and integration with...

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“…Tattoo based sensors have been widely developed [132] and used for different applications like as a potentiometric [133] and amperometric [134] sensor based systems. These devices have significant applications for skin worn silver (Ag) -zinc (Zn) alkaline batteries [135] and monitoring of change in pH [136] and ions like sodium and ammonium [137,138]. Chemical and biological sensing also involve pH measurements [139] by strapping the embedded system around the waist contained with the sensor connected with microcontrollers and LED.…”

Section: Sensor Network For Wearable Flexible Sensorsmentioning

confidence: 99%

Wearable Flexible Sensors: A Review

2017

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Abstract-The paper provides a review on some of the significant research work done on wearable flexible sensors (WFS). Sensors fabricated with flexible materials have been attached to a person along with the embedded system to monitor a parameter and transfer the significant data to the monitoring unit for further analyses. The use of wearable sensors has played a quite important role to monitor physiological parameters of a person to minimize any malfunctioning happening in the body. The paper categorizes the work according to the materials used for designing the system, the network protocols and different types of activities that were being monitored. The challenges faced by the current sensing systems and future opportunities for the wearable flexible sensors regarding its market values are also briefly explained in the paper.

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Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring

Cited by 433 publications

References 33 publications

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform

Nanomaterial‐Enabled Wearable Sensors for Healthcare

Wearable Flexible Sensors: A Review

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