Epidermodysplasia Verruciformis as a Model of Human Papillomavirus-lnduced Genetic Cancers: The Role of Local Immunosurveillance

Majewski, Slavomir; Jabłońska, Stefania

doi:10.1097/00000441-199209000-00006

Cited by 36 publications

(36 citation statements)

References 55 publications

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“…Enhanced but reversible T H 2-like responses, in conjunction with reduced or absent T H 1 function, in patients with HPVinfected skin and cervical tissues has been described (7,49,51,(53)(54)(55). Skin wart regression often occurs after trauma, and repeated immunization with HPV antigen can end HPV-specific "tolerance" (49,51,53). In addition CD4/CD8 ratios can also be reduced in both peripheral blood and TILs of patients with HPV-induced cervical disease (42,57).…”

mentioning

confidence: 99%

Recurrent Respiratory Papillomatosis: Altered CD8+ T-Cell Subsets and TH1/TH2 Cytokine Imbalance

Bonagura

Hatam

DeVoti

et al. 1999

Clinical Immunology

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mentioning

confidence: 99%

Recurrent Respiratory Papillomatosis: Altered CD8+ T-Cell Subsets and TH1/TH2 Cytokine Imbalance

Bonagura

Hatam

DeVoti

et al. 1999

Clinical Immunology

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“…The aim of the present study was to evaluate the association between TMC8 expression and HCC, with the aim of identifying a novel potential early diagnostic and prognostic biomarker. Previous studies suggested that the expression of TMC8 is closely associated with EV, a genodermatosis characterized by an immune defect and the development of skin cancer due to its selective susceptibility to HPV (12,13,19). It has been confirmed that EVER2 loss activates the c-Jun N-terminal kinase/activating protein-1 (AP-1) signaling pathway, which may contribute to the overexpression of interleukin (IL)-6 (9).…”

Section: Discussionmentioning

confidence: 99%

“…Defects of the TMC8 gene have been reported to be associated with the development of anogenital cancer (10,11), epidermodysplasia verruciformis (EV) (12)(13)(14)(15) and HPV-related head and neck squamous cell cancer (16), all of which are virus-associated diseases. Chronic hepatitis B virus (HBV) infection has been considered as the major risk factor for HCC development (17).…”

Section: Introductionmentioning

confidence: 99%

Transmembrane channel‑like protein 8 as a potential biomarker for poor prognosis of hepatocellular carcinoma

Ding

et al. 2017

mol clin onc

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Abstract. Hepatocellular carcinoma (HCC) is an aggressive malignant tumor and the third leading cause of cancer-related mortality worldwide. Transmembrane channel-like protein 8 (TMC8) is reported to play a major role in several aspects of human pathophysiology, such as ion channel permeability, human papillomavirus infection and skin cancer; however, its role in HCC has not been fully elucidated. The aim of the present study was to investigate the expression levels of TMC8 in 146 pairs of liver cancer samples and adjacent non-tumorous samples using immunohistochemistry. Reverse transcription-quantitative polymerase chain reaction analysis was used to confirm the results. The association between TMC8 expression and clinicopathological characteristics, including overall survival, was analyzed. The results indicated that the expression of TMC8 was significantly upregulated in HCC tissues and associated with metastasis and hepatitis B virus infection. According to the analysis of the overall survival using Cox proportional hazard regression model, higher expression of TMC8 was associated with a poorer prognosis and the overexpression of TMC8 was an independent risk factor for HCC. By contrast, HBsAg did not significantly affect the survival of HCC patients. These results suggest that the overexpression of TMC8 in HCC predicts poor prognosis and may be a potential biomarker for this type of cancer.

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“…The oncogenic power could also be increased by genetic factors specific to the transplant patient, as recently shown in cases of epidermodysplasia verruciformis [15]. It has been shown that certain HLA types, such as HLA 11, could confer resistance [2] and, on the contrary, that others, such as HLA B27 and HLA DR7 could induce susceptibility to developing skin cancers [4].…”

Section: Discussionmentioning

confidence: 99%

Frequency of mucosal HPV DNA detection (types 6/11, 16/18, 31/35/51) in skin lesions of renal transplant patients

Mansat-Krzyzanowska¹,

Dantal

Hourmant

et al. 1997

Transplant Int

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Human papillomaviruses (HPV) probably play a role in the development of skin cancer in renal transplant recipients. Since some mucosal HPV are strongly related to cervical cancer, we compared the frequency of HPV DNA detection (mucosal types 6/1 I , 16/18, and 31/ 33/51) in skin cancer of renal transplant recipients (21 lesions) with that in normal subjects without immunodeficiency (21 lesions) and studied the frequency of these same HPV in benign lesions of renal transplant recipients (34 lesions) and normal subjects (30 lesions). An in situ hybridization technique employing cold biotin probes was used. HPV DNA was not significantly ( P = 0.09.5) more frequent in malignant skin cancer in renal transplant recipients (42.9 %) than in normal subjects (19.04 %), but was significantly more frequent in benign lesions in renal transplant recipients (32.4 YO) than in controls (10 YO; P < 0.0.5). These results on a limited number of skin lesions do not allow one to confirm the predominant role of mucosal HPV in the development of skin cancer in renal transplant recipients. HPV interaction with other factors related to the immunosuppressive state may play a role.

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Epidermodysplasia Verruciformis as a Model of Human Papillomavirus-lnduced Genetic Cancers: The Role of Local Immunosurveillance

Cited by 36 publications

References 55 publications

Recurrent Respiratory Papillomatosis: Altered CD8+ T-Cell Subsets and TH1/TH2 Cytokine Imbalance

Recurrent Respiratory Papillomatosis: Altered CD8+ T-Cell Subsets and TH1/TH2 Cytokine Imbalance

Transmembrane channel‑like protein 8 as a potential biomarker for poor prognosis of hepatocellular carcinoma

Frequency of mucosal HPV DNA detection (types 6/11, 16/18, 31/35/51) in skin lesions of renal transplant patients

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