Epidermodysplasia verruciformis Neue Aspekte zur Symptomatologie und Pathogenese

Schellander, F; Fritsch, Peter

doi:10.1159/000252559

Cited by 21 publications

(8 citation statements)

References 3 publications

(3 reference statements)

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“…Since then, the condition has been the subject of discussion, until Ruiter and Van Mullem 2 in 1966 demonstrated human papillomavirus (HPV) particles in a tissue section on electron microscopy. Currently, it is recognized by the presence of numerous, extensive, erythematous, scaly, flat‐topped papules, plaques, and/or macules with a configuration identical to that of pityriasis versicolor 3–8 . It is largely a familial condition and its precise incidence is difficult to determine due to its sporadic reporting.…”

Section: Discussionmentioning

confidence: 99%

Epidermodysplasia verruciformis: 14 members of a pedigree with an intriguing squamous cell carcinoma transformation

2002

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A 38-year-old farmer was apparently well until 5 years of age. At this age, the patient's mother found mildly itchy, raised eruptions over the scalp during combing of the scalp hair. Since then, the eruptions have progressed insidiously to involve the face and other parts of the body, with a preponderance over the face, upper back, and chest, including the palms. The soles, oral cavity, and genital tract were unaffected. The lesions were persistent in nature and showed no remission or exacerbation. Mild to moderate pruritus/discomfort was experienced following sunlight exposure. A prominent, raised eruption appeared on the right side of the forehead 9 years ago, 25 years after the initial eruptions, which in due course ulcerated. It was progressive in nature and acquired a large size. Two years later, it was diagnosed as squamous cell carcinoma, for which liquid nitrogen cryosurgery was performed. There was a recurrence of the lesion at the site of surgery, which was excised 4 months later. Subsequently, there was a sudden flare up at the same site. It was badly infected with maggot infestation. The relentless course of the disease was evident by the appearance of two similar lesions, one on the right half of the nose and the other on the left preauricular region. A short while ago, fatigue and loss of weight were also recorded. Bladder and bowel functions were normal and there was no loss of appetite, hoarseness of voice, or breathlessness. Four of the patient's six children (three sons and one daughter) were reported to have similar lesions all over the body. In addition, nine other relatives were also affected. Accordingly, a total of 14 (12 males and two females) family members were found to be affected from amongst 41 individuals (26 males and 15 females) spread across several generations (Fig. 1). There was a second-degree consanguinity of marriage, with the patient's grandmother and wife's father being brother and sister. Skin surface examination was marked by multiple, discrete, flat-topped, scaly, brownish-black papules of diverse morphology, from hypopigmented macules to verrucous lesions, with a few coalescing to form plaques. The scales were brown, dry, and adherent (Fig. 2a). The lesions were conspicuous by their presence over the face, neck, and front and back of the chest. The extremities were also affected. Nevertheless, the soles and genitalia were spared. The oral mucosae, hair, and nails were normal. Koebner's phenomenon was explicit, whereas Auspitz's sign was not demonstrable. In addition, a perceptible nodulo-ulcerative lesion (size, 3 in x 2 in) with indurated, raised, averted margins was encountered on the right side of the forehead. The ulcer was tender and had a fetid discharge. Necrotic slough was prominent over its base. Similar lesions were located on the left preauricular region and right half of the nose. Hematoxylin and eosin-stained sections prepared from biopsies taken from representative lesions of epidermodysplasia verruciformis and squamous cell carcinoma revealed their diagno...

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Section: Discussionmentioning

confidence: 99%

Epidermodysplasia verruciformis: 14 members of a pedigree with an intriguing squamous cell carcinoma transformation

2002

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“…This skin disease is a generalized infection by the verruca virus. In approximately 20% of the cases the verrucous lesions of EV change into premalignant and malignant neoplasias [21], Malignant transformation of the other virus acanthomata is described as a rare occurrence. Zoltán [26] observed 4 cases showing malignant transformation within a total of 37 excised verrucae vulgares (3.2%), but he believes the number of cases to be too small for a statistical statement.…”

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confidence: 99%

Condylomata Acuminata Associated with Morbus Bowen (Carcinoma <i>in situ</i>)

Grussendorf¹,

Bär²

1977

Dermatology

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“…The presence of seborrhoeic keratoses in patients with EV has previ ously been reported [11,14,15] and it seems, at least in African patients, [9] that this associated occurrence may not have been purely fortuitous. Jablonska et al [4] and Orth et al [6] differentiated two morphological vari ants of EV, caused by different viruses and showing also a different tendency towards malignant changes.…”

Section: Discussionmentioning

confidence: 99%

Epidermodysplasia verruciformis in Nigerians

Jacyk¹,

Subbuswamy²

1979

Dermatology

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An analysis of the clinical and pathologic characteristics of 12 Nigerian patients with epidermodysplasia verruciformis (EV) is presented. Two morphological variants have been observed, typical wart-like flat-topped papules and larger confluent plaques. Seborrhoeic keratoses were observed in patients with the second morphological variety of EV. Solar elastosis was found in biopsies taken from EV lesions in this subgroup of patients. A particular rarity of seborrhoeic keratosis in Africans is emphasized as no single African case of seborrhoeic keratosis was found apart from patients with EV. No malignant epithelial skin tumours were found in the whole group. Factors underlying an apparently more benign course of EV in Africans are discussed, and the literature on EV in Africa is reviewed.

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Epidermodysplasia verruciformis Neue Aspekte zur Symptomatologie und Pathogenese

Cited by 21 publications

References 3 publications

Epidermodysplasia verruciformis: 14 members of a pedigree with an intriguing squamous cell carcinoma transformation

Epidermodysplasia verruciformis: 14 members of a pedigree with an intriguing squamous cell carcinoma transformation

Condylomata Acuminata Associated with Morbus Bowen (Carcinoma <i>in situ</i>)

Epidermodysplasia verruciformis in Nigerians

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