Epidermoid Carcinoma Arising in Extensive Chromoblastomycosis

Caplan, Richard

doi:10.1001/archderm.1968.01610070044007

Cited by 29 publications

(4 citation statements)

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“…When observed under the microscope, histological sections are shown to be composed of an external layer of fibrous tissue and an internal layer of thick granulomatous inflammatory tissue containing polymorphonuclear leukocytes, histiocytes and multinucleated giant cells (Silva & Ekizlerian, 1985;Brandt & Warnock, 2003). In some cases, especially the long standing ones, the presence of chronic inflammatory reaction and fibrous cicatricial tissue offer a favourable condition for the development of malignant skin neoplasm (Caplan, 1968;Foster & Harris, 1987;Dos Santos Gon & Minelli, 2006). Systemic invasion following chromoblastomycosis is very rare.…”

Section: Pathophysiology and Diagnosis Of Chromoblastomycosismentioning

confidence: 99%

Biology and pathogenesis ofFonsecaea pedrosoi, the major etiologic agent of chromoblastomycosis

et al. 2007

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Fonsecaea pedrosoi is the principal etiologic agent of chromoblastomycosis, a fungal disease whose pathogenic events are poorly understood. Treatment of the disease presents poor effectiveness and serious side effects. The disease is epidemiologically important in several regions, which has stimulated studies focused on the biology and pathogenic potential of its major causative agent. In this review, we summarize the current knowledge on the biological aspects of F. pedrosoi, including cell differentiation and pathogenic mechanisms during the interaction of fungi with different hosts' elements.

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Section: Pathophysiology and Diagnosis Of Chromoblastomycosismentioning

confidence: 99%

Biology and pathogenesis ofFonsecaea pedrosoi, the major etiologic agent of chromoblastomycosis

et al. 2007

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“…Secondary ulceration from trauma or infection is common. Surprisingly squamous cell carcinoma arising in the ulcers has rarely been reported (Bayles, 1971;Cameron, Gatei & Bremner, 1973;Caplan, 1968). Very uncommonly haematogenous spread and metastases occur in uninvolved areas ofthe body and in the brain.…”

mentioning

confidence: 99%

Chromomycosis: a review

Vollum

1977

Br J Dermatol

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“…New lesions develop by autoinoculation or through propagation by lymphatic vessels causing elephantiasis; hematogenous spread can also occur rarely. Development of squamous cell carcinoma had also been reported in the long standing cases (9). The HP of cutaneous Chromoblastomycosis reveals pseudoepitheliomatous hyperplasia, dermal abscess formation, chronic granulomatous inflammation with multinucleated giant cells and diagnostic 'copper penny' bodies (1,2,10).…”

Section: Discussionmentioning

confidence: 92%

Cutaneous chromoblastomycosis mimicking tuberculosis verrucosa cutis: look for copper pennies!

Bandyopadhyay¹,

Majumdar²,

Gangopadhyay³

et al. 2013

TJPATH

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Chromoblastomycosis is a rare chronic fungal infection of skin and subcutaneous tissue. It is primarily a disease of tropical and subtropical regions and affects mainly the agricultural workers following trauma with vegetable matter. Cutaneous Chromoblastomycosis may clinically mimic cutaneous tuberculosis as both the condition usually presents with hyper pigmented verrucous lesion of skin.Here in we report a case of chronic cutaneous Chromoblastomycosis in a middle aged woman from north eastern part of India, who was initially misdiagnosed as tuberculosis verrucosa cutis. In histopathology characteristic brown colored spores of the fungus (also known as copper pennies) were seen within dermal abscess. The organism isolated from culture of the biopsy material was Fonsecaea pedrosoi thus confirming our diagnosis of cutaneous chromoblastomycosis. The patient responded well to oral Itraconazole.The dermatologists and pathologists should be aware of this condition especially when dealing with verrucous lesion of the skin. The pathologists should search for fungal spores in cutaneous lesion with pseudoepitheliomatous hyperplasia and dermal abscess.

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Epidermoid Carcinoma Arising in Extensive Chromoblastomycosis

Cited by 29 publications

References 3 publications

Biology and pathogenesis ofFonsecaea pedrosoi, the major etiologic agent of chromoblastomycosis

Biology and pathogenesis ofFonsecaea pedrosoi, the major etiologic agent of chromoblastomycosis

Chromomycosis: a review

Cutaneous chromoblastomycosis mimicking tuberculosis verrucosa cutis: look for copper pennies!

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