Epidermoid carcinoma of the larynx occurring in two children with papilloma of the larynx

Walsh, Theodore E.; Beamer, Parker R.

doi:10.1288/00005537-195011000-00003

Cited by 70 publications

(17 citation statements)

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“…All three were later found to have squamous cell carcinoma. Walsh and Beamer (1950) also observed and reported limitation of vocal fold movement in one patient in whom the laryngeal papillomata underwent malignant transformation. Cervical lymphadenopathy This does not occur with benign laryngeal papillomata, as no report of this has been found in the literature.…”

Section: Limitation Of Vocal Fold Movementmentioning

confidence: 80%

“…Laryngeal papillomata can undergo malignant transformation without being detected histologically and, in some instances, the diagnosis only becomes apparent when there is either direct invasion of the soft tissue of the neck (Walsh and Beamer, 1950;Zehnder and Lyons, 1975;Kashima et al, 1988) or metastases (Siegel et al, 1979;Bewtraefo/., 1982).…”

Section: Introductionmentioning

confidence: 99%

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Clinical features of malignant transformation in benign laryngeal papillomata

Singh

Ramsaroop

1994

J. Laryngol. Otol.

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Laryngeal papillomata can undergo spontaneous malignant transformation without being detected histologically and, in some instances, the disease may become so advanced, before the diagnosis is confirmed, that it is beyond any form of curative treatment.Because of this limitation imposed by histopathological investigation, a study was undertaken in 17 adults with benign laryngeal papillomata, (three of whom underwent malignant transformation) to determine whether malignant transformation can be predicted from the clinical behaviour of the tumour. The following features were analysed: age, sex, patient's symptoms, frequency of excision of the papillomata, site of lesion, presence or absence of laryngeal oedema, the need for tracheostomy, vocal fold mobility and presence or absence of cervical lymph nodes.It was found that decreased vocal fold mobility, the presence of cervical lymph nodes, exuberant and rapid growth requiring very frequent excisions, oedema of the larynx with airway obstruction requiring a tracheostomy are clinical features suggestive of malignant transformation.

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Section: Limitation Of Vocal Fold Movementmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Clinical features of malignant transformation in benign laryngeal papillomata

Singh

Ramsaroop

1994

J. Laryngol. Otol.

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“…Although not all laryngeal carcinomas with HPV DNA showed HPV-suggestive morphology, and vice versa, these data clearly suggest that HPV may be involved in the etiology of laryngeal carcinomas, possibly arising from preexisting benign HPV lesions [1,6,28,42]. The malignant conversion of laryngeal papillomas [11,13,14,18,20,26,28,30,51,54,55] is generally ascribed to X-irradiation of the lesions [14, 26, 28], Several occasions have been reported, however, where malig nant transformation took place in the ab sence of irradiation [22,28,35,53], raising the question about the synergistic actions between HPV and other carcinogens [28,42,43,55,56].…”

Section: Discussionmentioning

confidence: 93%

“…Using an indirect immunoperoxidase (IP-PAP) technique, HPV an tigens have been demonstrated in some 50% of such lesions [7,9,24,25], and more recently, HPV DNA sequences (HPV 6 and HPV 11) have been disclosed in both the juvenile-and adult-onset laryngeal papillo mas by DNA hybridization [15,25,27,29,33,37], Albeit the majority of these tumors have an entirely benign appearance and clinical behavior, an increasing number of reports are available on invasive laryngeal papillo mas [12], occurrence of intraepithelial ana plastic changes [2], atypia up to 20-40% of cases [32], as well as malignant transforma tion observed in laryngeal papillomas [11,13,14,18,20,26,28,30,51,54], It is also well reegonized that laryngeal papillomas may prove fatal by extending into the lower respiratory tract [23,52], A malignant change is likely to occur in severe papillo matosis of long duration with signs of spread throughout the respiratory tract [28], This is more common (3-14%) in the juve nile-than adult-onset papillomas [54], There are reports on malignant transforma tion of the solitary adult-onset lesions as well [28,53], commonly associated with ra diation therapy [14,26,28], However, sev eral occasions have been reported where malignant transformation was evident in the absence of irradiation [18. 22, 28.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus DNA in Squamous Cell Carcinomas of the Larynx Demonstrated by in situ DNA Hybridization

Syrjänen¹,

Syrjänen

Mäntyjärvi³

et al. 1987

ORL

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A series of 116 consecutive laryngeal squamous cell carcinomas were analyzed using an in situ DNA hybridization technique with 35S-labelled human papillomavirus (HPV) DNA probes to demonstrate the DNA of HPV types 6, 11, 16 and 30, in routinely processed, paraffin-embedded biopsies. The lesions were also assessed on light microscopy for HPV-suggestive morphological features, and by indirect immunoperoxidase (IP-PAP) technique to demonstrate the expression of HPV structural proteins (viral antigens). A total of 15/116 (12.9 %) of the tumors were shown to contain the DNA of at least one HPV type. HPV 11 was the most frequent DNA type, found in 9/116 (7.8 %) of the lesions, followed by HPV 16 (5.2 %), and HPV 6 (4.3 %). Noteworthy is the failure to disclose the recently described HPV type 30 DNA (suggested to be specific for laryngeal carcinomas) in any of the 116 carcinomas studied. Double infections (more than one HPV type) were disclosed in 5 (33.3 % of the HPV DNA-positive) carcinomas: HPV 6 and 11, 1 case; HPV 6 and 16, 2 cases, and HPV 11 and 16, 2 cases. Light microscopic morphology was HPV-suggestive in 6 (40 %) of the 15 HPV DNA-positive lesions, but HPV antigen expression could be demonstrated in one of these tumors only (6.7%). The present findings provide support to the concept on HPV as an etiological agent in laryngeal squamous cell carcinoma, most probably acting synergistically with chemical carcinogens. In addition to the ‘high risk’ HPV 16, a risk to develop a laryngeal malignancy may be associated with the ‘low risk’ types HPV 6 and 11 as well, previously demonstrated in benign laryngeal papillomas only.

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“…Walsh 6 reported two carcinomas arising in papillomas in children. One was a 12 year old boy who had had papillomas in the larynx for eight years.…”

mentioning

confidence: 99%

VI Epithelial Neoplasms of the Larynx

1960

Ann Otol Rhinol Laryngol

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Epidermoid carcinoma of the larynx occurring in two children with papilloma of the larynx

Cited by 70 publications

References 0 publications

Clinical features of malignant transformation in benign laryngeal papillomata

Clinical features of malignant transformation in benign laryngeal papillomata

Human Papillomavirus DNA in Squamous Cell Carcinomas of the Larynx Demonstrated by in situ DNA Hybridization

VI Epithelial Neoplasms of the Larynx

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