Epidermotropic Epstein–Barr virus-Positive Diffuse Large B-Cell Lymphoma: A Series of 3 Cases of a Very Unusual High-Grade Lymphoma

Wu, Sam; Subtil, Antonio; Gru, Alejandro A.

doi:10.1097/dad.0000000000001718

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…Some cases can show epidermotropism. 53 As opposed to cases of cutaneous HL, solid sheets of large EBV+ cells are seen. The malignant cells show strong (not weak) PAX-5 and CD30 expression, and are also positive for CD20 and CD79a, as opposed to CHL.…”

Section: Discussionmentioning

confidence: 97%

Secondary skin involvement in classic Hodgkin lymphoma: Results of an international collaborative cutaneous lymphoma working group study of 25 patients

et al. 2021

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Background: Cutaneous involvement by classic Hodgkin lymphoma (CHL) is an extraordinarily rare phenomenon in the current era. To date, no single large case series of cutaneous involvement by Hodgkin lymphoma has ever been reported in the literature.Methods: A comprehensive search for cases designated "skin" and "Hodgkin" was performed at different institutions between 1990 and 2020. Twenty-five cases were identified, and each case was independently reviewed by at least three boardcertified dermatopathologists and/or hematopathologists. Results: All cases represented examples of systemic CHL with secondary skin dissemination. A single lesion, usually a tumor, nodule or infiltrative plaque was observed in 56% of cases and multiple lesions were present in 28% of cases. Most patients (86%-12/14) had a diagnosis of stage IV disease at first diagnosis. The interval between the clinical (first) diagnosis of HL and the development of skin lesions ranged between 6 and 108 months (average 33.75 months). Comprehensive histopathologic evaluation of these cases (at the initial diagnosis) revealed a diagnosis of classic HL not otherwise specified (NOS) in 60% of cases (15/25), nodular sclerosis type in 24% (6/25), mixed cellularity in 12% (3/25), and lymphocyte depleted in 4% (1/25).Conclusions: We provide documentation of a large series of CHL with secondary skin

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Section: Discussionmentioning

confidence: 97%

Secondary skin involvement in classic Hodgkin lymphoma: Results of an international collaborative cutaneous lymphoma working group study of 25 patients

et al. 2021

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“…Few cases have been reported of cutaneous B-cell lymphoma showing histologic features of T-cell lymphomas ( Table 1 ) 2 4 9 10 11 12 13 14 15 . Chui et al 4 reported a patient with pruritic rashes on the trunk, upper and lower limbs.…”

Section: Discussionmentioning

confidence: 99%

“…Wu et al 10 reported three cases presenting polymorphic EBV+ lymphocytes, including centroblasts, immunoblasts and sheets of immunoblastic cells. In addition, the tumors showed diffuse expression of CD20, CD19, CD79a, and PAX5.…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus Positive Diffuse Large B-Cell Lymphoma with Epidermotropism

Lee,

Pyo,

Myung

et al. 2023

Ann Dermatol

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Primary cutaneous B-cell lymphomas are rare diseases comprising nodular to diffuse lymphoid cell infiltration with an overlying grenz zone and no epidermal involvement upon histological analysis. Diagnostics can become challenging when lymphomas exhibit the characteristics of both B and T-cells. Differential diagnoses may include reactive proliferations, cutaneous composite lymphomas, and transformed mycosis fungoides. Immunohistochemistry and gene arrangement tests may be beneficial to clarify the diagnosis. Herein, we report a rare case of epidermotropic EBV-positive cutaneous B-cell lymphoma along with a literature review.

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“…Primary and secondary cutaneous B-cell lymphomas rarely show epidermotropic lymphoid infiltrates. Isolated reports or short series of epidermotropic diffuse large B-cell lymphoma, "mixed-cell lymphoma," chronic lymphocytic leukemia, Epstein-Barr virus-positive diffuse large B-cell lymphoma, 4 and primary cutaneous B-cell lymphoma with an accompanying epidermotropic reactive T-cell population have been reported; [1][2][3][4][5] however, the concept of epidermotropic B-cell lymphoma has been proposed to define a distinctive clinical and histopathologic presentation of extranodal B-cell marginal zone lymphoma (MZL), which often manifests as a generalized cutaneous eruption and characteristically precedes the presentation of a splenic MZL (SMZL) subtype. Some of these cases may initially fulfill the criteria for primary cutaneous MZL if splenic, bone marrow, and/or peripheral blood involvement cannot be demonstrated after staging.…”

Section: Introductionmentioning

confidence: 99%

Epidermotropic B-Cell Lymphoma: A Case of Secondary Cutaneous Splenic Marginal Zone B-Cell Lymphoma With Autoinvolutive and Recurrent Cutaneous Lesions

Rovira-López

Gallardo

Salar

et al. 2022

The American Journal of Dermatopathology

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:An 84-year-old woman presented with a 3-month history of a papular rash on the trunk, abdomen, and back. Histopathological examination revealed atypical lymphoid deep and band-like dermal infiltrates with marked epidermotropism. Neoplastic cells expressed B-cell markers (CD20), and clonal immunoglobulin gene rearrangement was observed. A complete peripheral blood study revealed aberrant circulating villous lymphocytes with the expression of B-cell markers (CD20, CD22, and CD79a) and aberrant expression of CD5. A staging workup revealed discrete splenic enlargement and bone marrow and gastrointestinal tract involvement. Skin lesions regressed spontaneously several weeks after diagnosis. Throughout evolution, the patient developed scattered cutaneous nodules and generalized papulo-nodules showing either epidermotropic or nonepidermotropic atypical dermal lymphoid infiltrates. This case illustrates the observation of autoinvolutive and recurrent epidermotropic B-cell atypical cutaneous infiltrates as a characteristic feature of secondary cutaneous involvement in splenic marginal B-cell lymphoma. Previously reported cases of epidermotropic B-cell lymphoma have been reviewed. Concurrent and simultaneous observation of epidermotropic and nonepidermotropic lesions seems to indicate that epidermotropism is an important but nonconstant diagnostic feature of splenic marginal B-cell lymphoma.

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Epidermotropic Epstein–Barr virus-Positive Diffuse Large B-Cell Lymphoma: A Series of 3 Cases of a Very Unusual High-Grade Lymphoma

Cited by 4 publications

References 30 publications

Secondary skin involvement in classic Hodgkin lymphoma: Results of an international collaborative cutaneous lymphoma working group study of 25 patients

Secondary skin involvement in classic Hodgkin lymphoma: Results of an international collaborative cutaneous lymphoma working group study of 25 patients

Epstein-Barr Virus Positive Diffuse Large B-Cell Lymphoma with Epidermotropism

Epidermotropic B-Cell Lymphoma: A Case of Secondary Cutaneous Splenic Marginal Zone B-Cell Lymphoma With Autoinvolutive and Recurrent Cutaneous Lesions

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