Epididymal leiomyoadenomatoid tumor: A case report with literature review

Wazwaz, Bara; Murshed, Khaled; Musa, Eiman; Taha, Noheir M; Akhtar, Mohammed

doi:10.1016/j.eucr.2020.101226

Cited by 4 publications

(8 citation statements)

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“…Adenomatoid tumors are benign neoplasms with no reported malignant transformation or potential recurrence after complete surgical resection [2,3,11]. Unnecessary orchidectomy should be avoided and surgery ideally limited to excisional biopsy of the lesion through inguinal or scrotal approach [11,19,20]. In our case, the preoperative diagnosis was epididymal cyst and excision of the lesion was performed with testicular-preserving surgery.…”

Section: Discussionmentioning

confidence: 82%

“…Ultrasonography (US) is widely used to investigate intrascrotal and paratesticular tumors. Adenomatoid tumors appear as a well-defined homogeneous hypoechoic or hyperechoic nodule with no increased blood flow on color Doppler US [11,16,19,20]. Adenomatoid tumors with intratesticular growth, especially when arising in tunica albuginea, tunica vaginalis or the rete testis, mimic malignant testicular tumors [12,13,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…On microscopic examination, adenomatoid tumors appear with microcystic, angiomatoid or trabecular architecture, solid or macrocystic patterns are rarely reported [1,9]. The tumor's stroma is usually fibrous with scattered lymphocytes, but sometimes the stroma may have prominent smooth muscle tissue, leading some authors to name the lesion as leiomyoadenomatoid tumor [1,[19][20][21]. The cells vary from flattened to vacuolated with abundant cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

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Epididymal adenomatoid tumor: a case report and literature review

et al. 2022

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Background Adenomatoid tumor is a very rare benign neoplasm of mesothelial origin affecting mainly female and male genital tracts. The diagnosis is challenging as this tumor mimics many differential diagnoses. The current literature offers only some case reports and short series of adenomatoid tumors. Case presentation A 47-year-old patient with unremarkable medical history presented for chronic mild pain of the right testis evolving for months. The physical examination shows a palpable right intrascrotal nodule of 10 mm in greatest diameter. The nodule was painful, mobile with firm consistency. The laboratory investigations were within normal limits, the scrotal ultrasonography showed a well-circumscribed predominantly hyperechoic intrascrotal nodule in the right epididymal head with heterogeneous echostructure. Excisional biopsy of the lesion was performed and the histopathological analysis showed a well-circumscribed tumor with microcystic and trabecular architecture made of small interconnected tubules and cysts lined by flattened cells with prominent vacuolization and thread-like bridging strands, consistent with an epididymal adenomatoid tumor. The postoperative course was uneventful and the patient was discharged. Four months after surgical treatment, the patient has no sign of the disease. Conclusion Testicular adenomatoid tumors are uncommon benign neoplasms with diagnostic challenge. Adenomatoid tumors arising in epididymis are managed by excisional biopsy with testis-sparing surgery avoiding unnecessary orchidectomy.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epididymal adenomatoid tumor: a case report and literature review

et al. 2022

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“…To the best of our knowledge, only six cases of leiomyoadenomatoid tumour of the epididymis have been previously described in the English literature (Table 1) (Almohaya et al., 2021; Cazorla et al., 2014; Kausch et al., 2002; Shehabeldin et al., 2020; Wazwaz et al., 2020). The notion of leiomyoadenomatoid tumour was first described by Epstein to classify an adenomatoid tumour lesion with a prominent smooth muscle component (Epstein, 1992).…”

Section: Discussionmentioning

confidence: 99%

Leiomyoadenomatoid tumours of the epididymis: A new case report and review of the literature

et al. 2021

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Benign tumours of the epididymis are rare, and the most common tumour types include adenomatoid tumours, representing more than half of all cases, and leiomyomas. Here, we reported a case of leiomyoadenomatoid tumours of the epididymis, a very rare, benign histological entity with only few cases described in the English literature, which have been reviewed and summarised. Clinically, the lesion presented as a solitary mass growing at the level of the tail of the right epididymis. After the intraoperative frozen section analysis revealed a benign adenomatoid lesion, the mass was enucleated with a conservative surgery sparing the testis. This case highlights the importance for both pathologists and urologists to be aware of these rare, but benign, tumours, to avoid misdiagnosis, especially in the setting of frozen intraoperative consultation, or primary radical surgical procedures, as radical orchiepididymectomy without frozen section consultation.

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“…An even rarer subvariant, Leiomyoadenomatoid tumor, has been described as a smooth muscle component that has been incorporated into the neoplasm. 1 Leiomyoadenomatoid tumors were first designated as a “mixed tumor of the epididymis” but were later renamed “leiomyoadenomatoid tumors”. 2 In some cases, the adenomatoid component may be overshadowed by the proliferative smooth muscle component making it difficult to diagnose on pathology.…”

Section: Introductionmentioning

confidence: 99%